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REFERENCES

  • 1
    ten Dijke P, Miyazono K, Heldin C-H 1996 Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors Curr Opin Cell Biol 8:139145.
  • 2
    Derynck R, Feng XH 1997 TGF-β receptor signaling Biochem Biophys Acta 1333:F105F150.
  • 3
    Massagué J, Attisano L, Wrana JL 1994 The TGF-β family and its composite receptors Trends Cell Biol 4:172178.
  • 4
    Wrana JL, Attisano L, Wieser R, Ventura F, Massagué J 1994 Mechanism of activation of the TGF-β receptor Nature 370:341347.
  • 5
    Yamashita H, ten Dijke P, Heldin CH, Miyazono K 1996 Bone morphogenetic protein receptors Bone 19:569574.
  • 6
    Wrana JL, Attisano L 1996 MAD-related proteins in TGF-β signalling Trends Genet 12:493496.
  • 7
    Massagué J, Hata A, Lie F 1997 TGF-β signalling through the Smad pathway Trends Cell Biol 7:187192.
  • 8
    Heldin CH, Miyazono K, ten Dijke P 1997 TGF-β signalling from cell membrane to nucleus through SMAD proteins Nature 390:465471.
  • 9
    Baker JC, Harland RM 1996 A Novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway Genes Dev 10:18801889.
  • 10
    Zhang Y, Feng X-H, Wu RY, Derynck R 1996 Receptor-associated Mad homologues synergize as effectors of the TGF-β response Nature 383:168172.
  • 11
    Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tui L-C, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L 1996 MADR2 maps to 18q21 and encodes a TGF-β-regulated MAD related protein that is functionally mutated in colorectal carcinoma Cell 86:543552.
  • 12
    Macias-Silva M, Abdollah S, Hoodless PA, Pirone R, Attisano L, Wrana JL 1996 MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling Cell 87:12151224.
  • 13
    Hoodless PA, Haerry T, Abdollah S, Stapleton M, O'Connor MB, Attisano L, Wrana JL 1996 MADR1, a MAD related protein that functions in BMP2 signaling pathways Cell 85:489500.
  • 14
    Graff JM, Bansal A, Melton DA 1996 Xenopus Mad proteins transduce distinct subsets of signals for the TGFβ superfamily Cell 85:479487.
  • 15
    Liu F, Hata A, Baker JC, Doody J, Cárcamo J, Harland RM, Massagué J 1996 A human Mad protein acting as a BMP-regulated transcriptional activator Nature 381:620623.
  • 16
    Kretzschmar M, Liu F, Hata A, Doody J, Massagué J 1997 The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase Genes Dev 11:984995.
  • 17
    Suzuki A, Chang C, Yingling JM, Wang XF, Hemmati-Brivanlou A 1997 Smad5 induces ventral fates in Xenopus embryo Dev Biol 184:402405.
  • 18
    Hoodless PA, Haerry T, Abdollah S, Stapelton M, O'Connor MB, Attisano L, Wrana JL 1996 MADR1, a MAD-related protein that functions in BMP2 signaling pathways Cell 85:489500.
  • 19
    Zhang Y, Musci T, Derynck R 1997 The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function Curr Biol 7:270276.
  • 20
    Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanaki J, Heldin C-H, Miyazono K, ten Dijke P 1997 TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4 EMBO J 16:53535362.
  • 21
    Imamura T, Takase M, Nishihara A, Oeda E, Hanai J, Kawabata M, Miyazono K 1997 Smad6 inhibits signalling by TGF-β superfamily Nature 389:622626.
  • 22
    Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin N-E, Heldin C-H, ten Dijke P 1997 Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling Nature 389:631635.
  • 23
    Hayashi H, Abdollah S, Qiu Y, Cai J, Xu X-Y, Grinnel EW, Richardson MA, Topper JN, Gimbrone MA-JR, Wrana JL, Falb D 1997 The MAD-related protein Smad7 associates with TGFβ receptor and functions as an Antagonist of TGFβ signaling Cell 89:11651173.
  • 24
    Hata A, Lagna G, Massagué J, Hemmati-Brivanlou A 1998 Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor Genes Dev 12:186197.
  • 25
    Reddi AH 1994 Bone and cartilage differentiation Curr Opin Genet Dev 4:737744.
  • 26
    Bonewald LF, Dallas SL 1994 Role of active and latent transforming growth factor β in bone formation J Cell Biochem 55:350357.
  • 27
    Barcellos-Hoff MH, Derynck R, Tsang ML, Weatherbee JA 1994 Transforming growth factor-β activation in irradiated murine mammary gland J Clin Invest 93:892899.
  • 28
    Hayashi K, Ishidou Y, Yonemori K, Nagamine T, Origuchi N, Maeda S, Imamura T, Kato M, Yoshida H, Sampath TK, ten Dijke P, Sakou T 1997 Expression and localization of bone morphogenetic proteins (BMPs) and BMP receptors in ossification of the ligamentum flavum Bone 21:2330.
  • 29
    Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA 1988 Novel regulators of bone formation: Molecular clones and activities Science 242:15281534.
  • 30
    Yamada N, Kato M, Yamashita H, Nistér M, Miyazono K, Heldin CH, Funa K 1995 Enhanced expression of transforming growth factor-β and its type-I and type-II receptors in human glioblastoma Int J Cancer 62:386392.
  • 31
    ten Dijke P, Yamashita H, Ichijo H, Franzén P, Laiho M, Miyazono K, Heldin CH 1994 Characterization of type I receptors for transforming growth factor-β and activin Science 264:101104.
  • 32
    Rosenzweig BL, Imamura T, Okadome T, Cox GN, Yamashita H, ten Dijke P, Heldin C-H, Miyazono K 1995 Cloning and characterization of a human type II receptor for bone morphogenetic proteins Proc Natl Acad Sci USA 92:76327636.
  • 33
    Tamaki K, Souchelnyskyi S, Itoh S, Nakao A, Sampath K, Heldin CH, ten Dijke P 1998 Intracellular signaling of osteogenic protein-1 through Smad5 activation J Cell Physiol 177:355363.
  • 34
    Hsu SM, Raine L, Fanger H 1981 Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures J Histochem Cytochem 29:577580.
  • 35
    Thorp BH, Jakowlew SB 1994 Altered localisation of transforming growth factor-β3 during endochondral ossification in rachitic chicks Bone 15:5964.
  • 36
    Carey DE, Lie X 1995 Expression of bone morphogenetic protein-6 messenger RNA in bovine growth plate chondrocytes of different size J Bone Miner Res 10:401405.
  • 37
    Farquharson C, Law AS, Seawright E, Burt DW, Whitehead CC 1996 The expression of transforming growth factor-β by cultured chick growth plate chondrocytes: Differential regulation by 1,25-dihydroxyvitamin D3 J Endocrinol 149:277285.
  • 38
    Erickson DM, Harris SE, Dean DD, Harris MA, Wozney JM, Boyan BD, Schwartz Z 1997 Recombinant bone morphogenetic protein (BMP)-2 regulates costochondral growth plate chondrocytes and induces expression of BMP-2 and BMP-4 in a cell maturation-dependent manner J Orthop Res 15:371380.
  • 39
    Urist MR 1965 Bone formation by autoinduction Science 150:893899.
  • 40
    Hogan BL 1996 Bone morphogenetic protein: Multifunctional regulators of vertebrate development Genes Dev 10:15801594.
  • 41
    Joyce ME, Roberts AB, Sporn MB, Bolander ME 1990 Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur J Cell Biol 110:21952207.
  • 42
    Tanaka T, Taniguchi Y, Gotoh K, Satoh R, Inazu M, Ozawa H 1993 Morphological study of recombinant human transforming growth factor beta 1-induced intramembranous ossification in neonatal rat parietal bone Bone 14:117123.
  • 43
    Oue Y, Kanatani H, Kiyoki M, Eto Y, Ogata E, Matsumoto T 1994 Effect of local injection of activin A on bone formation in newborn rats Bone 15:361366.
  • 44
    Duneas N, Crooks J, Ripamonti U 1998 Transforming growth factor-beta 1: Induction of bone morphogenetic protein genes expression during endochondral bone formation in the baboon, and synergistic interaction with osteogenic protein-1 (BMP-7) Growth Factors 15:259277.
  • 45
    Sakou T 1998 Bone morphogenetic proteins: From basic studies to clinical approaches Bone 22:591603.
  • 46
    Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, Gauthier JM 1998 Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene EMBO J 17:30913100.
  • 47
    Labbe E, Silvestri C, Hoodless PA, Wrana JL, Attsano L 1998 Smad2 and Smad3 positively regulate TGF-beta-dependent transcription through the forkhead DNA-binding protein FAST2 Mol Cell 2:109120.
  • 48
    Waldrip WR, Bikoff EK, Hoodless PA, Wrana JL, Robertson EJ 1998 Smad2 signaling in extraembryonic tissue determines anterior-posterior polarity of the early mouse embryo Cell 92:797808.
  • 49
    Nomura M, Li E 1998 Smad2 role in mesoderm formation, left-right pattering and craniofacial development Nature 393:786790.
  • 50
    Weinstein M, Yang X, Li C, Xu X, Gotay J, Deng CX 1998 Failure of egg cylinder elongation and mesoderm induction in mouse enbryos lacking the tumor suppressor Smad2 Proc Natl Acad Sci USA 95:93789383.
  • 51
    Zhu Y, Richardson JA, Parada LF, Graff JM 1998 Smad3 mutant mice develop metastatic colorectal cancer Cell 94:703714.
  • 52
    Yamamoto N, Akiyama S, Katagiri T, Namiki M, Kurokawa T, Suda T 1997 Smad1 and Smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts Biochem Biophys Res Commun 238:574580.
  • 53
    Nishimura R, Kato Y, Chen D, Harris SE, Mundy GR, Yoneda T 1998 Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12 J Biol Chem 273:18721879.
  • 54
    Takase M, Imamura T, Sampath K, Takeda K, Ichijo H, Miyazono K, Kawabata M 1998 Induction of Smad6 mRNA by bone morphogenetic proteins Biochem Biophys Res Commun 224:2629.
  • 55
    Afrakhte M, Moren A, Jossan S, Itoh S, Sampath K, Westermark B, Heldin CH, Heldin NE, ten Dijke P 1998 Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members Biochem Biophys Res Commun 249:505511.
  • 56
    Itoh S, Landström A, Itoh F, Heldin C-H, Heldin N-H, ten Dijke P 1998 Transforming growth factor β1 induces nuclear export of inhibitory Smad7 J Biol Chem 273:2919629201.