This work was presented, in part, at the meeting of the European Symposium on Calcified Tissue in Harrogate, U.K., April 1997, and the ASBMR in Cincinnati, OH, U.S.A., September 1997.
Age-Related Changes in Bone Turnover in Men†
Article first published online: 1 JUL 1999
Copyright © 1999 ASBMR
Journal of Bone and Mineral Research
Volume 14, Issue 7, pages 1203–1210, July 1999
How to Cite
Fatayerji, D. and Eastell, R. (1999), Age-Related Changes in Bone Turnover in Men. J Bone Miner Res, 14: 1203–1210. doi: 10.1359/jbmr.19188.8.131.523
- Issue published online: 2 DEC 2009
- Article first published online: 1 JUL 1999
- Manuscript Accepted: 4 MAR 1999
- Manuscript Revised: 2 DEC 1998
- Manuscript Received: 11 MAY 1998
Biochemical markers of bone turnover can be used to study the pathophysiology of osteoporosis. So far there have been few such studies in men. The aims of this study were to determine the effect of aging on bone turnover and to identify which hormones might regulate bone turnover in men. We studied 178 healthy Caucasian men, ages 20–79 years (30 per decade). The data for the effect of age on bone turnover was best fit by a quadratic function (nadirs at age 56, 57, 53, 39, and 58 years for intact propeptide of type I procollagen, osteocalcin, bone alkaline phosphatase, free deoxypyridinoline, and cross-linked N-telopeptides of type I collagen, respectively). For most markers, bone turnover tended to be highest in the third decade, lowest in the fifth and sixth decade, with a small increase in some markers in the eighth decade. Insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3, dehydroepiandrosterone sulfate, testosterone, estradiol, and free androgen index all decreased significantly with age (54, 17, 76, 26, 33, and 57%, respectively), while sex hormone binding globulin and parathyroid hormone increased significantly with age (62% and 43%). IGF-I and sex hormones were positively correlated with bone turnover, and this association was stronger in young men than older men. In conclusion, increased IGF-I and sex hormones may be associated with increased bone turnover in young men, with less influence on bone turnover in older men.