• 1
    Taipale J, Keski-Oja J 1997 Growth factors in the extracellular matrix. FASEB J 11:5159.
  • 2
    Sakai LY, Keene DR, Engvall E 1986 Fibrillin, a new 350-kD glycoprotein is a component of extracellular microfibrils. J Cell Biol 103:24992509.
  • 3
    Zhang H, Apfelroth SD, Hu W, Davis EC, Sanguineti C, Bonadio J, Mecham RP, Ramirez F 1994 Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices. J Cell Biol 124:855863.
  • 4
    Kanzaki T, Olofsson A, Morén A, Wernstedt C, Hellman U, Miyazono K, Claesson-Welsh L, Heldin CH 1990 TGFβ1 binding protein: A component of the large latent complex of TGFβ1, with multiple repeat sequences. Cell 61:10511061.
  • 5
    Tsuji T, Okada F, Yamaguchi K, Nakamura T 1990 Molecular cloning of the large subunit of transforming growth factor type β masking protein and expression of the mRNA in various rat tissues. Proc Natl Acad Sci USA 87:88358839.
  • 6
    Morén A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, Ten Dijke P, Miyazono K, Heldin CH 1994 Identification and characterization of LTBP-2, a novel latent transforming growth factor-β binding protein. J Biol Chem 269:3246932478.
  • 7
    Gibson MA, Hatzinikolas G, Davis EC, Baker E, Sutherland ER, Mecham RP 1995 Bovine latent transforming growth factor β1-binding protein-2: molecular cloning, identification of tissue isoforms and immunolocalization to elastin-associated microfibrils. Mol Cell Biol 15:69326942.
  • 8
    Bashir MM, Han MD, Abrams WR, Tucker T, Ma RI, Gibson MA, Ritty T, Mecham RP, Rosenbloom J 1996 Analysis of the human gene encoding latent transforming growth factor-β-binding protein-2. Int J Biochem Cell Biol 28:531542.
  • 9
    Yin W, Smiley E, Germiller J, Mecham RP, Florer JV, Wenstrup RJ, Bonadio J 1995 Isolation of a novel latent transforming growth factor-β binding protein gene (LTBP-3). J Biol Chem 270:1014710160.
  • 10
    Giltay R, Kostka G, Timpl R 1997 Sequence and expression of a novel member (LTBP4) of the family of latent transforming growth factor-β binding proteins. FEBS Lett 411:164168.
  • 11
    Saharinen J, Taiple J, Monni O, Keski-Oja J 1998 Identification and characterization of a new latent transforming growth factor-β-binding protein, LTBP-4. J Biol Chem 273:1845918469.
  • 12
    Hyytiäinen M, Taipale J, Heldin CH, Keski-Oja J 1998 Recombinant latent transforming growth factor β-binding protein 2 assembles to fibroblast extracellular matrix and is susceptible to proteolytic processing and release. J Biol Chem 273:2066920676.
  • 13
    Border WA, Ruoslahti E 1992 Transforming growth factor-β in disease: the dark side of tissue repair. J Clin Invest 90:17.
  • 14
    Bonewald LF, Dallas SL 1994 The role of active and latent TGFβ in bone formation. J Cell Biochem 55:350357.
  • 15
    Taipale J, Saharinen J, Keski-Oja J 1998 Extracellular matrix-associated transforming growth factor-β: role in cancer cell growth and invasion. Adv Cancer Res 75:87134.
  • 16
    Roberts AB 1998 Molecular and cell biology of TGF-beta. Miner Electrolyte Metab 24:111119.
  • 17
    Bonewald LF 1999 Regulation and regulatory activities of transforming growth factor β. Crit Rev Eukaryot Gene Expr 9:3344.
  • 18
    Gentry LE, Webb NR, Lim JG, Brunner AM, Ranchialis JE, Twardzik DR, Lioubin MN, Marquardt H, Purchio HF 1987 Type I transforming growth factor beta: Amplified expression and secretion of mature and precursor polypeptides in Chinese hamster ovary cells. Mol Cell Biol 7:34183427.
  • 19
    Bonewald LF, Wakefield L, Oreffo ROC, Escobedo A, Twardzik DR, Mundy GR 1991 Latent forms of transforming growth factor-beta (TGFβ) derived from bone cultures. Identification of a naturally occurring 100-kDa complex with similarity to recombinant latent TGFβ. Mol Endocrinol 5:741751.
  • 20
    Dallas SL, Park-Snyder S, Miyazono K, Twardzik D, Mundy GR, Bonewald LF 1994 Characterization and autoregulation of latent transforming growth factor β (TGFβ) complexes in osteoblast-like cell lines. J Biol Chem 269:68156822.
  • 21
    Miyazono K, Olofsson A, Colosetti P, Heldin CH 1991 A role of the latent TGFβ1- binding protein in the assembly and secretion of TGFβ1. EMBO J 10:10911101.
  • 22
    Flaumenhaft R, Abe M, Sato Y, Miyazono K, Heldin CH, Rifkin DB 1993 Role of the latent TGF-β binding protein in the activation of latent TGFβ by co-cultures of endothelial and smooth muscle cells. J Cell Biol 120:9951002.
  • 23
    Taipale J, Miyazono K, Heldin CH, Keski-Oja J 1994 Latent transforming growth factor-β1 associates to fibroblast extracellular matrix via latent TGF-β binding protein. J Cell Biol 124:171181.
  • 24
    Taipale J, Saharinen J, Hedman K, Keski-Oja J 1996 Latent transforming growth factor-β1 and its binding protein are components of extracellular matrix microfibrils. J Histochem Cytochem 44:875889.
  • 25
    Dallas SL, Miyazono K, Skerry TM, Mundy GR, Bonewald LF 1995 Dual role for the latent TGFβ binding protein (LTBP) in storage of latent TGFβ in the extracellular matrix and as a structural matrix protein. J Cell Biol 131:539549.
  • 26
    Nakajima Y, Miyazono K, Kato M, Takase M, Yamagishi T, Nakamura H 1997 Extracellular fibrillar structure of latent TGFβ binding protein-1: role in TGFβ-dependent epithelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart. J Cell Biol 136:193204.
  • 27
    Handford PA, Mayhew M, Baron M, Winship PR, Campbell ID, Brownlee GG 1991 Key residues involved in calcium-binding motifs in EGF-like domains. Nature 351:164167.
  • 28
    Maslen CL, Glanville RW 1993 The molecular basis of Marfan Syndrome. DNA Cell Biol 12:561572.
  • 29
    Ramirez F, Pereira H, Zhang H, Lee B 1993 The fibrillin-Marfan Syndrome connection. Bioessays 15:589594.
  • 30
    Kielty CM, Shuttleworth CA 1995 Fibrillin-containing microfibrils: structure and function in health and disease. Int. J Biochem Cell Biol 27:747760.
  • 31
    Reinhardt DP, Chalberg SC, Sakai LY 1995 The structure and function of fibrillin. Ciba Foundation Symp 192:128143.
  • 32
    Ramirez F 1996 Fibrillin mutations in Marfan syndrome and related phenotypes. Curr Opin Genet Dev 6:309315.
  • 33
    Pedrozo HA, Schwartz Z, Gomez R, Ornoy A, Xin-Sheng W, Dallas SL, Bonewald LF, Dean DD, Boyan BD 1998 Growth plate chondrocytes store latent TGFβ in their matrix through latent TGFβ binding protein. J Cell Physiol 177:343354.
  • 34
    Dietz HC, Pyeritz RE 1995 Mutations in the human gene for fibrillin-1 (FBN1) in the Marfan syndrome and related disorders. Hum Mol Genet 4:17991809.
  • 35
    Collod-Béroud G, Béroud C, Adès L, Black C, Boxer M, Brock DJ, Godfrey M, Hayward C, Karttunen L, Milewicz D, Peltonen L, Richards RI, Wang M, Junien C, Boileau C 1997 Marfan database (second edition): software and database for the analysis of mutations in the human FBN1 gene. Nucleic Acids Res 25:147150.
  • 36
    Ghosh-Choudhury N, Windle JJ, Koop BA, Harris MA, Guerrero DL, Wozney JM, Mundy GR, Harris SE 1996 Immortalized murine osteoblasts derived from BMP-2-T-antigen expressing transgenic mice. Endocrinology 137:331339.
  • 37
    Pereira L, Andrikopoulos K, Tian J, Lee SY, Keene DR, Ono R, Reinhardt DP, Sakai LY, Biery NJ, Bunton T, Dietz HC, Ramirez F 1997 Targeting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan Syndrome. Nat Genet 17:218222.
  • 38
    Saharinen J, Taipale J, Keski-Oja J 1996 Association of the small latent transforming growth factor-β with an eight cysteine repeat of its binding protein LTBP1. EMBO J 15:245253.
  • 39
    Reddy SV, Takehashi S, Haipek C, Chirgwin JM, Roodman GD 1993 Tartrate-resistant acid phosphatase gene expression as a facile reporter gene for screening transfection efficiency in mammalian cell cultures. Biotechniques 15:444447.
  • 40
    Sakai LY, Keene DR, Glanville RW, Bachinger HP 1991 Purification and partial characterization of fibrillin, a cysteine-rich structural component of connective tissue microfibrils. J Biol Chem 266:1476314770.
  • 41
    Bruder SP, Caplan AI 1989 Cellular and molecular events during embryonic bone development. Connect Tissue Res 20:6571.
  • 42
    Mosher DF, McKeown-Longo PJ 1985 Assembly of fibronectin-containing extracellular matrix: a glimpse of the machinery. Biopolymers 24:199210.
  • 43
    Godyna S, Mann DM, Argraves WS 1994 A quantitative analysis of the incorporation of fibulin-1 into extracellular matrix indicates that fibronectin assembly is required. Matrix Biol 14:467477.
  • 44
    Nunes I, Gleizes P, Metz CN, Rifkin DB 1997 Latent transforming growth factor-β- binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-β. J Cell Biol 136:11511163.
  • 45
    Kohlmeier L, Gasner C, Bachrach LK, Marcus R 1995 The bone mineral status of patients with Marfan syndrome. J Bone Miner Res 10:15501555.
  • 46
    Zhang H, Hu W, Ramirez F 1995 Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils. J Cell Biol 129:11651166.
  • 47
    Gibson MA, Cleary EG 1987 The immunohistochemical localisation of microfibril-associated glycoprotein (MAGP) in elastic and non-elastic tissues. Immunol Cell Biol 65:345356.
  • 48
    Gibson MA, Hatzinikolas G, Kumaratilake JS, Sandberg LB, Nicholl JK, Sutherland GR, Cleary EG 1996 Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25). J Biol Chem 271:10961013.
  • 49
    Argraves WS, Dickerson K, Burgess WH, Ruoslahti E 1989 Fibulin, a novel protein that interacts with the fibronectin receptor β subunit cytoplasmic domain. Cell 58:623629.
  • 50
    Pan TC, Sasaki T, Zhang RZ, Fassler R, Timpl R, Chu ML 1993 Structure and function of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding. J Cell Biol 123:12691277.
  • 51
    Schwartz E, Goldfischer S, Coltoff-Schiller B, Blumenfeld O 1985 Extracellular matrix microfibrils are composed of core proteins coated with fibronectin. J Histochem Cytochem 33:268274.
  • 52
    Zimmermann DR, Dours-Zimmermann MT, Schubert M, Bruckner-Truderman L 1994 Versican is expressed in the proliferating zone in the epidermis and in association with the elastic network of the dermis. J Cell Biol 124:817825.
  • 53
    Arbeille BB, Fauvel-Lafeve FMJ, Lemesle MB, Tenza D, Jegrand LY 1991 Thrombospondin: a component of microfibrils in various tissues. J Histochem Cytochem 39:13671375.
  • 54
    Bressan G, Daga-Gordini D, Colombatti A, Castellani I, Marigo V, Volpin D 1993 Emelin, a component of elastic fibers preferentially located at the elastin-microfibrils interface. J Cell Biol 121:201212.