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  • 1
    Fleisch H 1998 Bisphosphonates: Mechanisms of action. Endocr Rev 19:80100.
  • 2
    Russell RGG, Rogers MJ, Frith JC, Luckman SP, Coxon FP, Benford HL, Croucher PI, Shipman C, Fleisch HA 1999 The pharmacology of bisphosphonates and new insights into their mechanisms of action. J Bone Miner Res 14(Suppl 2):5365.
  • 3
    Rodan GA 1998 Mechanisms of action of bisphosphonates. Annu Rev Pharmacol Toxicol 38:375388.
  • 4
    Russell RGG, Muhlbauer RC, Bisaz S, Williams DA, Fleisch H 1970 The influence of pyrophosphate, condensed phosphates, phosphonates and other phosphate compounds on the dissolution hydroxyapatite in vitro and on bone resorption induced by parathyroidectomised rats. Calcif Tissue Res 6:183196.
  • 5
    Schenk R, Merz WAM, Muhlbauer R, Russell RGG, Fleisch H 1973 Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (C12MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats. Calcif Tissue Res 11:196214.
  • 6
    Shinoda H, Adamek G, Felix R, Fleisch H, Schenk R, Hagan P 1983 Structure-activity relationships of various bisphosphonates. Calcif Tissue Int 35:8799.
  • 7
    Schenk R, Eggli P, Fleisch H, Rosini S 1986 Quantitative morphometric evaluation of the inhibitor activity of new aminobisphosphonates on bone resorption in the rat. Calcif Tissue Int 38:342349.
  • 8
    Gasser AB, Morgan DB, Fleisch H, Richelle LJ 1972 The influence of two bisphosphonates on calcium metabolism in the rat. Clin Sci 43:3145.
  • 9
    Parfit AM, Mundy GR, Roodman GD, Hughes DE, Boyce BF 1996 A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates. J Bone Miner Res 11:150159.
  • 10
    Sato M, Grasser W, Endo N, Akins R, Simmons H, Thompson DD, Golub E, Rodan GA 1991 Bisphosphonate action: Alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest 88:20952105.
  • 11
    Hughes DE, Wright KR, Uy HL, Sasaki A, Yoneda T, Roodman GD, Mundy GR, Boyce BF 1995 Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res 10:14781487.
  • 12
    Selander KS, Monkkonen J, Karhukorpi E-K, Harkonen P, Hannuniemi R, Vaananen HK 1996 Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages. Mol Pharmacol 50:11271138.
  • 13
    Hughes DE, MacDonald BR, Russell RGG, Gowen M 1989 Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow. J Clin Invest 83:19301935..
  • 14
    Lowik CWGM, van der Pluijm G, van der Wee-Pals LJA, Bloys van Treslong-de Groot H, Bijvoet OLM 1988 Migration and phenotypic transformation of osteoclast precursors into mature osteoclasts: The effect of a bisphosphonate. J Bone Miner Res 3:185192.
  • 15
    Canalis E, Pash J, Varghese S 1993 Skeletal growth factors. Crit Rev Eukaryot Gene Expr 3:155166.
  • 16
    Murphy G 1995 Matrix metalloproteinases and their inhibitors. Acta Orthop Scand 66(Suppl 266):5560.
  • 17
    Borden P, Solymar D, Sucharczuk A, Lindman B, Cannon P, Heller RA 1996 Cytokine control of interstitial collagenase and collagenase-3 gene expression in human chondrocytes. J Biol Chem 271:2357723581.
  • 18
    Stahle-Backdahl M, Sandstedt B, Bruce K, Lindahl A, Jimenez MC, Vega JA, Lopez-Otin C 1997 Collagenase-3 (MMP-13) is expressed during human ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis. Lab Invest 76:717728..
  • 19
    Varghese S, Canalis E 1997 Regulation of collagenase-3 by bone morphogenetic protein-2 in bone cell cultures. Endocrinology 138:10351040.
  • 20
    Holliday LS, Welgus HG, Fliszart CJ, Veith GM, Jeffrey JJ, Gluck SL 1997 Initiation of osteoclast bone resorption by interstitial collagenase. J Biol Chem 272:2205322058..
  • 21
    McCarthy TL, Centrella M, Canalis E 1988 Further biochemical and molecular characterization of primary rat parietal bone cell cultures. J Bone Miner Res 3:401408.
  • 22
    Sambrook J, Fritsch EF, Maniatis T 1989 Molecular Cloning—A Laboratory Manual, 2nd Ed. Cold Spring Harbor Laboratory Press, Plainview, NY, U.S.A.
  • 23
    Quinn CO, Scott DK, Brinckerhoff CE, Matrisian LM, Jeffrey JJ, Partridge NC 1990 Rat collagenase: Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells. J Biol Chem 265:2234222347.
  • 24
    Edwards DR, Waterhouse P, Holman ML, Denhardt DT 1986 A growth responsive gene (16C8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity: Evidence for inducible and constitutive transcripts. Nucleic Acids Res 14:88638878.
  • 25
    Leco KJ, Hayden LJ, Sharma RR, Rocheleau H, Greenberg AH, Edwards DR 1992 Differential regulation of TIMP-1, and TIMP-2 mRNA expression in normal and Ha-ras-transformed murine fibroblasts. Gene 117:209217.
  • 26
    Leco KJ, Khokha R, Pavloff N, Hawkes SP, Edwards DR 1994 Tissue inhibitor of metalloproteinase-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. J Biol Chem 269:93529360.
  • 27
    Tso JY, Sun XH, Kao T-H, Reece KS, Wu R 1985 Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: Genomic complexity and molecular evolution of the gene. Nucleic Acids Res 13:24852502.
  • 28
    Genovese C, Rowe D, Kream B 1984 Construction of DNA sequences complementary to rat a1 and a2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D. Biochemistry 23:62166221.
  • 29
    Ausubel FM, Brent R, Kingsten RE, Moore DD, Seidman JG, Smith JA, Struhl K 1992 Current Protocols in Molecular Biology. Greene and Wiley Interscience, New York, NY, U.S.A.
  • 30
    Jeffrey JJ, Roswit WT, Ehlich LS 1990 Regulation of collagenase production by steroids in uterine smooth muscle cells: An enzymatic and immunologic study. J Cell Physiol 143:396403.
  • 31
    Sokal RR, Rohlf FJ 1981 Biometry, 2nd Ed. WH Freeman and Co., San Francisco, CA, U.S.A.
  • 32
    Zandomeni R, Bunick D, Aukerman S, Mittleman B, Weinmann R 1983 Mechanism of action of DRB. Effect of specific in vitro initiation of transcription. J Mol Biol 167:561574.
  • 33
    Knauper V, Will H, Lopez-Otin C, Smith B, Atkinson SJ. Stanton H, Hembry RM, Murphy G 1996 Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase A (MMP-2) are able to generate active enzyme. J Biol Chem 271:1712417131.
  • 34
    Franchimont N, Rydziel S, Delany AM, Canalis E 1997 Interleukin-6 and its soluble receptor causes a marked induction of collagenase-3 expression in rat osteoblast cultures. J Biol Chem 272:1214412150.
  • 35
    Kusano K, Miyaura C, Inada M, Tamura T, Ito A, Nagase H, Kamoi K, Suda T 1998 Regulation of matrix metalloproteinases (MMP-2, −3, −9, and −13) by interleukin-1 and interleukin-6 in mouse calvariae: Association of MMP induction with bone resorption. Endocrinology 139:13381345.
  • 36
    Zhao W, Byrne MH, Boyce BF, Krane SM 1999 Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice. J Clin Invest 103:517524.
  • 37
    Franchimont N, Durant D, Canalis E 1997 Interleukin-6 and its soluble receptor regulate the expression of insulin-like growth factor binding protein-5 in osteoblast cultures. Endocrinology 138:33803386.
  • 38
    Luckman SP, Hughes DE, Coxon FP. Russell RGG, Rogers MJ 1998 Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res 13:581589.
  • 39
    Fisher JE, Rogers MJ, Halasy JM, Luckman SP, Hughes DE, Masarachia PJ, Wesolowski G, Russell RGG, Rodan GA, Reszka AA 1999 Mechanism of action of alendronate: Geranylgeraniol, an intermediate of the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption and kinase activation in vitro. Proc Natl Acad Sci USA 96:133138.
  • 40
    Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC, Bellido T 1999 Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J Clin Invest 104:13631374.
  • 41
    Rydziel S, Varghese S, Canalis E 1997 Transforming growth factor β1 inhibits collagenase 3 expression by transcriptional and post-transcriptional mechanisms in osteoblast cultures. J Cell Physiol 170:145152.
  • 42
    Holmbeck K, Bianco P, Caterina J, Yamada S, Kromer M, Kuznetsov SA, Mankani M, Robey PG, Poole AR, Pidoux I, Ward JM, Birkedal-Hansen H 1999 MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell 99:8192.
  • 43
    Stepan JJ, Vokrouhlicka J 1999 Comparison of biochemical markers of bone remodeling in the assessment of the effects of alendronate on bone in postmenopausal osteoporosis. Clin Chim Acta 288:121135.
  • 44
    Schneider PF, Fischer M, Allolio B, Felsenberg D, Schroder U, Semler J, Ittner JR 1999 Alendronate increases bone density and bone strength at the distal radius in postmenopausal women. J Bone Miner Res 14:13871393.
  • 45
    Gertz BJ, Holland SD, Kline WF, Matuszewshi BK, Porras AG 1993 Clinical pharmacology of alendronate sodium. Osteoporos Int 3(Suppl 3):S13S16.
  • 46
    Porras AG, Holland SD, Gertz BJ 1999 Pharmacokinetics of alendronate. Clin Pharmocokinet 36:315328.