• 1
    Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Ebert S 1987 Genetic determinants of bone mass in adults: A twin study. J Clin Invest 80: 706710.
  • 2
    Slemenda CW, Christian JC, Williams CJ, Norton JA, Johnston CCJ 1991 Genetic determinants of bone mass in adult women: A reevaluation of the twin model and the potential importance of gene interaction on heritability estimates. J Bone Miner Res 6: 561567.
  • 3
    Hopper JL, Green RM, Nowson CA, Young D, Sherwin AJ, Kaymakci B, Larkins RG, Wark JD 1998 Genetic, common environment, and individual specific components of variance for bone mineral density in 10- to 26-year-old females: A twin study. Am J Epidemiol 147: 1729.
  • 4
    Hansen MA, Hassager C, Jensen SB, Christiansen C 1992 Is heritability a risk factor for postmenopausal osteoporosis? J Bone Miner Res 7: 10371043.
  • 5
    Gueguen R, Jouanny P, Guillemin F, Kuntz C, Pourel J, Siest G 1995 Segregation analysis and variance components analysis of bone mineral density in healthy families. J Bone Miner Res 10: 20172022.
  • 6
    Kanis JA, Melton LJ 3rd, Christiansen C, Johnston CC, Khaltaev NJ 1994 The diagnosis of osteoporosis. J Bone Miner Res 9: 11371141.
  • 7
    Kelly PJ, Morrison NA, Sambrook PN, Nguyen TV, Eisman JA 1995 Genetic influences on bone turnover, bone density and fracture. Eur J Endocrinol 133: 265271.
  • 8
    Girasole G, Jilka RL, Passeri G, Boswell HS, Boder G, Williams DC, Manolagas SC 1992 17β-estradiol inhibits interleukin-6 production by murine bone marrow stromal cells and human osteoblasts in vitro: A potential mechanism for the anti-osteoporotic effects of estrogens. J Clin Invest 89: 883891.
  • 9
    Jilka RL, Hangoc G, Girasole G, Passeri G, Williams D, Abrams J, Broxmeyer H, Manolagas SC 1992 Increased osteoclast development after estrogen loss: Mediation by interleukin-6. Science 257: 8891.
  • 10
    Bellido T, Jilka RL, Boyce B, Girasole G, Broxmeyer H, Dalrymple SA, Murray R, Manolagas SC 1995 Regulation of interleukin-6, osteoclastogenesis and bone mass by androgens: the role of the androgen receptor. J Clin Invest 95: 28862895.
  • 11
    Manolagas SC, Jilka RL 1995 Bone marrow, cytokines, and bone remodeling: Emerging concepts for the pathophysiology of osteoporosis. N Engl J Med 332: 305311.
  • 12
    Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC 1998 Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids: potential mechanisms of their deleterious effects on bone. J Clin Invest 102: 274282.
  • 13
    Silberman M, Weiss A, Resnick AZ, Edam Y, Seydel N, Gershon D 1987 Age-related trend for osteopenia in femurs of female C57BL/6 mice. Comp Geront 1: 4551.
  • 14
    Kobayashi Y, Goto S, Tanno T, Yamazaki M, Moriya H 1998 Regional variations in the progression of bone loss in two different mouse osteopenia models. Calcif Tissue Int 62: 426436.
  • 15
    Parfitt AM 1992 The two-stage concept of bone loss revisited. Triangle 31: 99110.
  • 16
    Rogers J, Mahaney MC, Beamer WG, Donahue LR, Rosen CJ 1997 Beyond one gene-one disease: Alternative strategies for deciphering genetic determinants of osteoporosis. Calcif Tissue Int 60: 225228.
  • 17
    Takeda T, Hosokawa M, Higuchi K 1994 Senescence-accelerated mouse (SAM). A novel murine model of aging. In: TakedaT (ed.) The SAM Model of Senescence. Elsevier Science, Amsterdam, pp. 1521.
  • 18
    Matsushita M, Tsuboyama T, Kasai R, Okumura H, Yamamuro T, Higuchi K, Kohno A, Yonezu T, Utani A, Umezawa M, Takeda T 1986 Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis. Am J Pathol 125: 276283.
  • 19
    Jilka RL. Weinstein RS. Takahashi K. Parfitt AM. Manolagas SC 1996 Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. J Clin Invest 97: 17321740.
  • 20
    Kajkenova O, Lecka-Czernik B, Gubrij I, Hauser SP, Takahashi K, Parfitt AM, Jilka RL, Manolagas SC, Lipschitz DA 1997 Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia. J Bone Miner Res 12: 17721779.
  • 21
    Weinstein RS, Jilka RL, Parfit AM, Manolagas SC 1997 Effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage. Endocrinology 138: 40134021.
  • 22
    Lecka-Czernik B, Gubrij I, Moerman E, Kajkenova O, Lipschitz DA, Manolagas SC, Jilka RL 1999 Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARγ2. J Cell Biochem 74: 114.
  • 23
    Kachigan SK 1986 Statistical Analysis. Radius Press, New York, NY, U.S.A., pp. 182185.
  • 24
    Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, Newburg L 1987 MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1: 174181.
  • 25
    Basten CJ, Weir BS, Zeng Z-B 1998 QTL Cartographer: A Reference ManualTutorial for QTL Mapping. Department of Statistics, North Carolina State University, Raleigh NC, U.S.A.
  • 26
    Zeng Z-B 1994 Precision mapping of quantitative trait loci. Genetics 136: 14571468.
  • 27
    Churchill GA, Doerge RW 1994 Empirical threshold values for quantitative trait mapping. Genetics 138: 963971.
  • 28
    Doerge RW, Churchill GA 1996 Permutation tests for multiple loci affecting a quantitative character. Genetics 142: 285294.
  • 29
    Lander ES, Botstein D 1989 Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185199. See also Erratum: Genetics 136:705.
  • 30
    Dietrich WF, Miller J, Steen R, Merchant MA, Damron-Boles D, Husain Z, Dredge R, Daly MJ, Ingalls KA, O'Connor TJ, Evans CA, DeAngelis MM, Levinson DM, Kruglyak L, Goodman N, Copeland NG, Jenkins NA, Hawkins TL, Stein L, Page DC, Lander ES 1996 A comprehensive genetic map of the mouse genome. Nature 380: 149152. See also Erratum: Nature 381:172.
  • 31
    Lynch M, Walsh B 1998 GeneticsAnalysis of Quantitative Traits. Sinauer Associates, Inc., Sunderl, MA, U.S.A.
  • 32
    Klein RF, Mitchell SR, Phillips TJ, Belnap JK, Orwoll ES 1998 Quantitative trait loci affecting peak bone mineral density in mice. J Bone Miner Res 13: 16481656.
  • 33
    Shimizu M, Higuchi K, Bennett B, Xia C, Tsuboyama T, Kasai S, Chiba T, Fujisawa H, Kogishi K, Kitado H, Kimoto M, Takeda N, Matsushita M, Okumura H, Serikawa T, Nakamura T, Johnson TE, Hosokawa M 1999 Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain. Mamm Genome 10: 8187.
  • 34
    Johnson ML, Gong G, Kimberling W, Recker SM, Kimmel DB, Recker RB 1997 Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13). Am J Hum Genet 60: 13261332.
  • 35
    Spiegelman BM, Flier JS 1996 Adipogenesis and obesity: Rounding out the big picture. Cell 87: 377389.
  • 36
    Kodama Y, Takeuchi Y, Suzawa M, Fukumoto S, Kurokawa T 1996 Reduced expression of interleukin-11 from bone marrow stromal cells of Senescence-Accelerated Mice (SAMP6): A role for impaired osteoblast and osteoclast formation. J Bone Miner Res 11: s105 (abstract).
  • 37
    Abe E, Yamamoto M, Taguchi Y, Lecka-Czernik B, Economides AC, Stahl N, Jilka RL, Manolagas SC 1998 Requirement of BMPs-2/4 for postnatal osteoblast as well as osteoclast formation: Antagonism by noggin. J Bone Miner Res 13: s242 (abstract).