• 1
    Hock JM, Centrella M, Canalis E 1988 Insulin-like growth factor I has independent effects on bone matrix formation and cell replication. Endocrinology 122:254260.
  • 2
    Delany AM, Pash JM, Canalis E 1994 Cellular and clinical perspectives on skeletal insulin-like growth factor I. J Cell Biochem 55:328333.
  • 3
    Rechler MM 1993 Insulin-like growth factor binding proteins. Vitam Horm 47:1114.
  • 4
    Hassager C, Fitzpatrick LA, Spencer EM, Riggs BL, Conover CA 1992 Basal and regulated secretion of insulin-like growth factor binding proteins in osteoblast-like cells is cell line specific. J Clin Endocrinol Metab 75:228233.
  • 5
    Okazaki R, Riggs BL, Conover CA 1994 Glucocorticoid regulation of insulin- like growth factor binding protein expression in normal human osteoblast-like cells. Endocrinology 134:126132.
  • 6
    McCarthy TL, Casinghino S, Centrella M, Canalis E 1994 Complex pattern of insulin-like growth factor binding protein expression in primary rat osteoblast enriched cultures: Regulation by prostaglandin E2, growth hormone, and the insulin-like growth factors. J Cell Physiol 160:163175.
  • 7
    Andress DL, Birnbaum RS 1992 Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action. J Biol Chem 267:2246722472.
  • 8
    Andress DL 1995 Heparin modulates the binding of insulin-like growth factor (IGF) binding protein-5 to a membrane protein in osteoblastic cells. J Biol Chem 270:2828928296.
  • 9
    Bautista CM, Baylink DJ, Mohan S 1991 Isolation of a novel insulin-like growth factor (IGF) binding protein from human bone: A potential candidate for fixing IGF-II in human bone. Biochem Biophys Res Commun 176:756763.
  • 10
    Mohan S 1993 Insulin-like growth factor binding proteins in bone cell regulation. Growth Regul 3:6770.
  • 11
    Slootweg MC, Most WW, van Beek E, Schot LPC, Papapoulos SE, Lowik CWGM 1992 Osteoclast formation together with interleukin-6 production in mouse long bones is increased by insulin-like growth factor-I. J Endocrinol 132:433438.
  • 12
    Mochizuki H, Hakeda Y, Wakatsuki N, Usui N, Akashi S, Sato T, Tanaka K, Kumegawa M 1992 Insulin-like growth factor-I supports formation and activation of osteoclasts. Endocrinology 131:10751080.
  • 13
    Hill PA, Reynolds JJ, Meikle MC 1995 Osteoblasts mediate insulin-like growth factor-I and -II stimulation of osteoclast formation and function. Endocrinology 136:124131.
  • 14
    Nishiyama K, Sugimoto T, Kaji H, Kanatani M, Kobayashi T, Chihara K 1996 Stimulatory effect of growth hormone on bone resorption and osteoclast differentiation. Endocrinology 137:3541.
  • 15
    Conover CA, Bale LK, Clarkson JT, Torring O 1993 Regulation of insulin-like growth factor binding protein-5 messenger ribonucleic acid expression and protein availability in rat osteoblast-like cells. Endocrinology 132:25252530.
  • 16
    Takada Y, Kusuda M, Hiura K, Sato T, Mochizuki H, Nagao Y, Tomura M, Yahiro M, Hakeda Y, Kawashima H, Kumegawa M 1992 A simple method to assess osteoclast-mediated bone resorption using unfractionated bone cells. Bone Miner 17:347359.
  • 17
    Kaji H, Sugimoto T, Kanatani M, Miyauchi A, Kimura T, Sakakibara S, Fukase M, Chihara K 1994 Carboxyl-terminal parathyroid hormone fragments stimulate osteoclast-like cell formation and osteoclastic activity. Endocrinology 134:18971904.
  • 18
    Kanatani M, Sugimoto T, Fukase M, Chihara K 1994 Role of interleukin-6 and prostaglandins in the effect of monocyte-conditioned medium on osteoclast formation. Am J Physiol 267(Endocrinol Metab 30):E868E876.
  • 19
    Kurihara N, Suda T, Miura Y, Nakauchi H, Kodama H, Hiura K, Hakeda Y, Kumegawa M 1989 Generation of osteoclasts from isolated hematopoietic progenitor cells. Blood 74:12951302.
  • 20
    Sugimoto T, Kanatani M, Kano J, Kaji H, Tsukamoto T, Yamaguchi T, Fukase M, Chihara K 1993 Effects of high calcium concentration on the functions and interactions of osteoblastic cells and monocytes and on the formation of osteoclast-like cells. J Bone Miner Res 8:14451452.
  • 21
    Sugimoto T, Kanatani M, Kaji H, Yamaguchi T, Fukase M, Chihara K 1993 Second messenger signaling of PTH- and PTHRP-stimulated osteoclast- like cell formation from hemopoietic blast cells. Am J Physiol 265(Endocrinol Metab 28):E367E373.
  • 22
    Hakeda Y, Hiura K, Sato T, Okazaki R, Matsumoto T, Ogata E, Ishitani R, Kumegawa M 1989 Existence of parathyroid hormone binding sites on murine hemopoietic blast cells. Biochem Biophys Res Commun 163:14811486.
  • 23
    Kanatani M, Sugimoto T, Takahashi Y, Kaji H, Kitazawa R, Chihara K 1998 Estrogen via the estrogen receptor blocks cAMP-mediated parathyroid hormone (PTH)-stimulated osteoclast formation. J Bone Miner Res 13:854862.
  • 24
    Kodama H, Amagai Y, Koyama H, Kasai S 1982 A new preadipose cell line derived from newborn mouse calvaria can promote the proliferation of pluripotent hemopoietic stem cells in vitro. J Cell Physiol 112:8995.
  • 25
    Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin TJ, Suda T 1989 The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 125:18051813.
  • 26
    Kodama H, Sudo H, Koyama H, Kasai S, Yamamoto S 1984 In vitro hemopoiesis within a microenvironment created by MC3T3-G2/PA6 preadipocytes. J Cell Physiol 118:233240.
  • 27
    Kakudo S, Miyazawa K, Kameda T, Mano H, Mori Y, Yuasa T, Nakamaru Y, Shiokawa M, Nagahira K, Tokunaga S, Hakeda Y, Kumegawa M 1996 Isolation of highly enriched rabbit osteoclasts from collagen gels: A new assay system for bone-resorbing activity of mature osteoclasts. J Bone Miner Metab 14:129136.
  • 28
    Mano H, Yuasa T, Kameda T, Miyazawa K, Nakamaru Y, Shiokawa M, Mori Y, Yamada T, Miyata K, Shindo H, Azuma H, Hakeda Y, Kumegawa M 1996 Mammalian mature osteoclasts as estrogen target cells. Biochem Biophys Res Commun 223:637642.
  • 29
    Kanatani M, Sugimoto T, Kaji H, Kobayashi T, Nishiyama K, Fukase M, Kumegawa M, Chihara K 1995 Stimulatory effect of bone morphogenetic protein-2 on osteoclast-like cell formation and bone-resorbing activity. J Bone Miner Res 10:16811690.
  • 30
    Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ 1999 Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20:345357.
  • 31
    Mohan S, Nakao Y, Honda Y, Landale E, Leser U, Dony C, Lang K, Baylink DJ 1995 Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells. J Biol Chem 270:2042420431.
  • 32
    Takahashi N, Udagawa N, Suda T 1999 A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function. Biochem Biophys Res Commun 256:449455.
  • 33
    Bertrand F, Philippe C, Antoine PJ, Baud L, Groyer A, Capeau J, Cherqui G 1995 Insulin activates nuclear factor κB in mammalian cells through a Raf-1-mediated pathway. J Biol Chem 270:2443524441.
  • 34
    Lowik CWGM, van der Pluijm G, Bloys H, Hoekman K, Bijvoet OLM, Aarden LA, Papapoulos SE 1989 Parathyroid hormone (PTH) and PTH- like protein (PLP) stimulate interleukin-6 production by osteogenic cells: A possible role of interleukin-6 in osteoclastogenesis. Biochem Biophys Res Commun 162:15461552.
  • 35
    Muench MO, Schneider JG, Moore MA 1992 Interactions among colony- stimulating factors, IL-1β, IL-6, and kit-ligand in the regulation of primitive murine hematopoietic cells. Exp Hematol 20:339349.
  • 36
    Stein B, Yang MA 1995 Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kB and C/EBPβ. Mol Cell Biol 15:49714979.
  • 37
    Galien R, Garcia T 1997 Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-kB site. Nucleic Acids Res 25:24242429.
  • 38
    Franchimont N, Durant D, Canalis E 1997 Interleukin-6 and its soluble receptor regulate the expression of insulin-like growth factor binding protein-5 in osteoblast cultures. Endocrinology 138:33803386.
  • 39
    Franchimont N, Gangji V, Durant D, Canalis E 1997 Interleukin-6 with its soluble receptor enhances the expression of insulin-like growth factor-I in osteoblasts. Endocrinology 138:52485255.
  • 40
    Jelinek DF, Witzig TE, Arendt BK 1997 A role for insulin-like growth factor in the regulation of IL-6-responsive human myeloma cell line growth. J Immunol 159:487496.
  • 41
    Bourette RP, von Ruden T, Ballmer-Hofer K, Morle F, Blanchet JP, Mouchiroud G 1992 Insulin-like growth factor-1 stimulates proliferation of myeloid FDC-P1 cells overexpressing the human colony-stimulating factor-1 receptor. Growth Factors 7:315325.
  • 42
    Varticovski L, Druker B, Morrison D, Cantley L, Roberts T 1989 The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase. Nature 342:699702.
  • 43
    Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S 1991 Oncogenes and signal transduction. Cell 64:281302.