• 1
    Anonymous 1993 Consensus development conference: Prophylaxis and treatment of osteoporosis. Am J Med 94:646650.
  • 2
    World Health Organization (WHO) Study Group 1994 Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO technical report series 843. Geneva, WHO.
  • 3
    Croucher PI, Garrahan NJ, Compston JE 1994 Structural mechanisms of trabecular bone loss in primary osteoporosis: Specific disease mechanism or early ageing? Bone Miner 25:111121.
  • 4
    Birkenhäger-Frenkel DH, Courpron P, Hüpscher EA, Clermonts E, Coutinho MF, Schmitz PIM, Meunier PJ 1988 Age-related changes in cancellous bone structure: A two-dimensional study in the transiliac and iliac crest biopsy sites. Bone Miner 4:197216.
  • 5
    Mellish RWE, Garrahan NJ, Compston JE 1989 Age-related changes in trabecular width and spacing in human iliac crest biopsies. Bone Miner 6:331338.
  • 6
    Parfitt AM, Mathews CHE, Villanueva AR, Kleerekoper M, Frame B, Rao DS 1983 Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. J Clin Invest 72:13961409.
  • 7
    Kimmel DB, Recker RR, Gallagher JC, Vaswani AS, Aloia JF 1990 A comparison of iliac bone histomorphometric data in postmenopausal osteoporotic and normal subjects. Bone Miner 11:217235.
  • 8
    Kleerekoper M, Villanueva AR, Stanciu J, Rao DS, Parfitt AM 1985 The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures. Calcif Tissue Int 37:594597.
  • 9
    Recker RR, Smith RT, Kimmel DB 1992 Loss of trabecular connectivity in osteoporosis demonstrated with independent methods. Bone 13:A28.
  • 10
    Parisien M, Mellish RWE, Schnitzer M, Nieves J, Cosman F, Recker RR, Kimmel D, Silverberg SJ, Shane E, Bilezikian JP, Lindsay R, Dempster DW 1992 Structural variables in postmenopausal women: Comparison among normal women and patients with osteoporosis or primary hyperparathyroidism. Bone 13:A26.
  • 11
    Garrahan NJ, Mellish RWE, Compston JE 1986 A new method for the two-dimensional analysis of bone structure in human iliac crest biopsies. J Microsc 142:341349.
  • 12
    Foldes J, Parfitt AM, Shih MS, Rao DS, Kleerekoper M 1991 Structural and geometric changes in iliac bone: Relationship to normal aging and osteoporosis. J Bone Miner Res 6:759766.
  • 13
    Riggs BL, Khosla S, Melton LJ III 1998 A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 13:763773.
  • 14
    Riggs BL, Melton JL III 1986 Involutional osteoporosis. N Engl J Med 314:16761686.
  • 15
    Riggs BL, Wahner WH, Dunn WL, Mazess RB, Offord KP, Melton JL III 1981 Differential changes in bone mineral density of the appendicular and axial skeleton with aging. J Clin Invest 67:328335.
  • 16
    Parfitt AM 1998 A structural approach to renal bone disease. J Bone Miner Res 13:12131220.
  • 17
    Ritzel H, Amling M, Pösl M, Hahn M, Delling G 1997 The thickness of human vertebral cortical bone and its changes in aging and osteoporosis: A histomorphometric analysis of the complete spinal column from thirty-seven autopsy specimens. J Bone Miner Res 12:8995.
  • 18
    Vesterby A, Mosekilde L, Gundersen HJG, Melsen F, Mosekilde L, Holme K, Sørensen S 1991 Biologically meaningful determinants of the in vitro strength of lumbar vertebrae. Bone 12:219224.
  • 19
    Genant HK, Wu CY, van Kuijk C, Nevitt MC 1993 Vertebral fracture assessment using a semi-quantitative technique. J Bone Miner Res 8:11371148.
  • 20
    Ettinger B, Black DM, Mitlak BH, Knickerbocker RK, Nickelsen T, Genant HK, Christiansen C, Delmas PD, Zanchetta JR, Stakkestad J, Gluer CC, Krueger K, Cohen FJ, Eckert S, Ensrud KE, Avioli LV, Lips P, Cummings SR 1999 Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators [see comments]. JAMA 282:637645.
  • 21
    Buijs R, Dogterom AA 1983 An improved method for embedding hard tissue in polymethyl methacrylate. Stain Technology 58:135141.
  • 22
    Kragstrup J, Gundersen HJG, Melsen F, Mosekilde L 1982 Estimation of the three-dimensional wall thickness of completed remodeling sites in iliac trabecular bone. Metab Bone Dis Rel Res 4:113119.
  • 23
    Uitewaal PJM, Lips P, Netelenbos JC 1987 An analysis of bone structure in patients with hip fracture. Bone Miner 3:6373.
  • 24
    Compston JE, Vedi S, Stellon AJ 1986 Inter-observer and intra-observer variation in bone histomorphometry. Calcif Tissue Int 38:6770.
  • 25
    Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR 1987 Bone histomorphometry: Standardisation of nomenclature, symbols, and units. Report of the ASBMR histomorphometry nomenclature committee. J Bone Miner Res 2:595610.
  • 26
    Compston JE 1994 Connectivity of cancellous bone: Assessment and mechanical implications. Bone 15:463466.
  • 27
    Compston JE, Garrahan NJ, Croucher PI, Wright CPD, Yamaguchi K 1993 Quantitative analysis of trabecular bone structure. Bone 14:187192.
  • 28
    Vesterby A 1990 Star volume of marrow space and trabeculae in iliac crest: Sampling procedure and correlation to star volume of first lumbar vertebra. Bone 11:149155.
  • 29
    Hahn M, Vogel M, Pompesius-Kempa M, Delling G 1992 Trabecular bone pattern factor—a new parameter for simple quantification of bone microarchitecture. Bone 13:327330.
  • 30
    Croucher PI, Garrahan NJ, Compston JE 1996 Assessment of cancellous bone structure: comparison of strut analysis, trabecular bone pattern factor, and marrow space star volume. J Bone Miner Res 11:955961.
  • 31
    Mazess RB 1990 Fracture risk: A role for compact bone. Calcif Tissue Int 47:191193.
  • 32
    Yoganandan N, Myklebust JB, Cusick JF, Wilson CR, Sances A Jr 1988 Functional biomechanics of the thoracolumbar vertebral cortex. Clin Biomech 3:1118.
  • 33
    Mosekilde Li, Mosekilde Le 1986 Normal vertebral bone size and compressive strength: Relations to age and to vertebral and iliac trabecular bone compressive strength. Bone 7:207212.
  • 34
    Rockhoff SD, Sweet E, Bleustein J 1969 The relative contribution of trabecular and cortical bone to the strength of human lumbar spine. Calcif Tissue Res 3:163175.
  • 35
    McBroom RJ, Hayes WC, Edwards WT, Goldberg RP, White AA 1985 Prediction of vertebral compressive fracture using quantitative computed tomography. J Bone Joint Surg 67A:12061214.
  • 36
    Kalender WA, Felsenberg D, Louis O, Lopez P, Klotz E, Osteaux M, Fraga J 1989 Reference values for trabecular and cortical vertebral bone density in single and dual-energy quantitative computed tomography. Eur J Radiol 9:7580.
  • 37
    Delmas PD, Fontanges E, Duboeuf F, Boivin G, Chavassieux P, Meunier PJ 1988 Comparison of bone mass measured by histomorphometry on iliac biopsy and by dual photon absorptiometry of the lumbar spine. Bone 9:209213.
  • 38
    Mosekilde L, Viidik A, Mosekilde L 1985 Correlation between the compressive strength of iliac and vertebral trabecular bone in normal individuals. Bone 6:291295.
  • 39
    Dempster DW, Ferguson-Pell M, Mellish RWE, Fey C, Parisien MV, Horbert W, Cochran GVB 1989 Relationships among cancellous bone structure and strength in the iliac crest and the lumbar spine. J Bone Miner Res 4:s191 (a294).
  • 40
    Parisien MV, McMahon D, Pushparaj N, Dempster DW 1988 Trabecular architecture in iliac crest bone biopsies: Intra-individual variability in structural parameters and changes with age. Bone 9:289295.
  • 41
    Meunier PJ, Courpron P 1976 Iliac trabecular bone volume in 236 controls: Representativeness of iliac samples. In: JaworskiZGF (ed.) Proceedings of the First Workshop on Bone morphometry. University of Ottawa Press, Ottawa pp. 100105.
  • 42
    Pødenphant J, Gotfredsen A, Nilas H, Nørgaard H, Brændstrup O 1986 Iliac crest biopsy: Representativity for the amount of mineralised bone. Bone 7:427430.
  • 43
    Mellish RWE, Ferguson-Pell MW, Cochran GVB, Lindsay R, Dempster DW 1991 A new manual method for assessing two-dimensional cancellous bone structure: Comparison between iliac crest and lumbar vertebra. J Bone Miner Res 6:689696.
  • 44
    Amling M, Herden S, Pösl M, Hahn M, Ritzel H, Delling G 1996 Heterogeneity of the skeleton: Comparison of the trabecular microarchitecture of the spine, the iliac crest, the femur and the calcaneus. J Bone Miner Res 11:3645.
  • 45
    Giroux JM, Courpron P, Meunier P 1975 Etude de la representativite de la biopsie osseuse iliaque. In: Histomorphometrie de l'osteopenie Physiologique Senile. Thesis Lyon University, Lyon, pp. 8997.
  • 46
    Arlot ME, Delmas PD, Chappard D, Meunier PJ 1990 Trabecular and endocortical bone remodeling in postmenopausal osteoporosis: Comparison with normal postmenopausal women. Osteoporos Int 1:4149.
  • 47
    Chavassieux P, Arlot ME, Reda C, Wei Lynn, Yates AJ, Meunier PJ 1997 Histomoprhometric assessment of the lon-term efects of alendronate on bone quality and remodeling inpatients with osteoporosis. J Clin Invest 100:14751480.
  • 48
    Boivin G, Klaushofer K, Roschger P, Rinnerthaler S, Fratzl P, Chavassieux P, Santora AC, Yates AJ, Meunier PJ 1998 Alendronate increases the mean degree of mineralisation of bone and the uniformity of mineralization of bone in osteoporotic women. (abstract) Bone 23:F282.