• 1
    Lefebvre V, De Crombrugghe B 1998 Toward understanding SOX9 function in chondrocyte differentiation. Matrix Biol 16:529540.
  • 2
    Kent J, Wheatley SC, Andrews JE, Sinclair AH, Koopman P 1996 A male-specific role for SOX9 in vertebrate sex determination. Development 122:28132822.
  • 3
    Morais Da Silva S, Hacker A, Harley V, Goodfellow P, Swain A, Lovell-Badge R 1996 Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds. Nat Genet 14:6268.
  • 4
    Lefebvre V, Huang W, Harley VR, Goodfellow PN, De Crombrugghe B 1997 SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol Cell Biol 17:23362346.
  • 5
    Ng LJ, Wheatley S, Muscat GE, Conway-Campbell J, Bowles J, Wright E, Bell DM, Tam PP, Cheah KS, Koopman P 1997 SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. Dev Biol 183:108121.
  • 6
    Bell DM, Leung KK, Wheatley SC, Ng LJ, Zhou S, Ling KW, Sham MH, Koopman P, Tam PP, Cheah KS 1997 SOX9 directly regulates the type-II collagen gene. Nat Genet 16:174178.
  • 7
    Bridgewater LC, Lefebvre V, De Crombrugghe B 1998 Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer. J Biol Chem 273:149985006.
  • 8
    Sekiya I, Tsuji K, Koopman P, Watanabe H, Yamada Y, Shinomiya K, Nifuji A, Noda M 2000 SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6. J Biol Chem 275:1073810744.
  • 9
    Bi W, Deng JM, Zhang Z, Behringer RR, De Crombrugghe B 1999 Sox9 is required for cartilage formation. Nat Genet 22:8589.
  • 10
    Kwok C, Weller PA, Guioli S, Foster JW, Mansour S, Zuffardi O, Punnett HH, Dominguez-Steglich MA, Brook JD, Young ID 1995 Mutations in SOX9, the gene responsible for Campomelic dysplasia and autosomal sex reversal. Am J Hum Genet 57:10281036.
  • 11
    Foster JW, Dominguez-Steglich MA, Guioli S, Kowk G, Weller PA, Stevanovic M, Weissenbach J, Mansour S, Young ID, Goodfellow PN, Brook J, Schafer AJ 1994 Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. Nature 372:525230.
  • 12
    Wagner T, Wirth J, Meyer J, Zabel B, Held M, Zimmer J, Pasantes J, Bricarelli FD, Keutel J, Hustert E, Wolf U, Tommerup N, Schempp W, Scherer G 1994 Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9. Cell 79:11111120.
  • 13
    Meyer J, Sudbeck P, Held M, Wagner T, Schmitz ML, Bricarelli FD, Eggermont E, Friedrich U, Haas OA, Kobelt A, Leroy JG, Van Maldergem L, Michel E, Mitulla B, Pfeiffer RA, Schinzel A, Schmidt H, Scherer G 1997 Mutational analysis of the SOX9 gene in campomelic dysplasia and autosomal sex reversal: Lack of genotype/phenotype correlations. Hum Mol Genet 6:9198.
  • 14
    McDowall S, Argentaro A, Ranganathan S, Weller P, Mertin S, Mansour S, Tolmie J, Harley V 1999 Functional and structural studies of wild type SOX9 and mutations causing campomelic dysplasia. J Biol Chem 274:2402324030.
  • 15
    Lefebvre V, Li P, De Crombrugghe B 1998 A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J 17:57185733.
  • 16
    Reddi AH 1998 Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat Biotechnol 16:247252.
  • 17
    Healy C, Uwanogho D, Sharpe PT 1999 Regulation and role of Sox9 in cartilage formation. Dev Dyn 215:6978.
  • 18
    Murakami S, Kan M, McKeehan WL, De Crombrugghe B 2000 Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway Proc Natl Acad Sci USA 97:11131118.
  • 19
    Wozney JM, Rosen V 1998 Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin Orthop 346:2637.
  • 20
    Lyons KM, Pelton RW, Hogan BL 1989 Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. Genes Dev 3:16571668.
  • 21
    Lyons KM, Pelton RW, Hogan BL 1990 Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development 109:833844.
  • 22
    Ashhurst DE 1990 Collagens synthesized by healing fractures. Clin Orthop 255:273283.
  • 23
    Sandberg MM, Aro HT, Vuorio EI 1993 Gene expression during bone repair. Clin Orthop 289:292312.
  • 24
    Hiltunen A, Vuorio E, Aro HT 1993 A standardized experimental fracture in the mouse tibia. J Orthop Res 11:305312.
  • 25
    Wilkinson GWG, Akrigg A 1992 Constitutive and enhanced expression of the CMV major IE promoter in defective adenovirus promoter. Nucleic Acids Res 20:22332239.
  • 26
    Chirgwin JM, Przybyla AE, Macdonald RJ, Rutter WJ 1979 Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:52945299.
  • 27
    Metsaranta M, Toman D, De Crombrugghe B, Vuorio E 1991 Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs. Biochim Biophys Acta 1089:241243.
  • 28
    Elima K, Metsaranta M, Kallio J, Perala M, Eerola I, Garofalo S, De Crombrugghe B, Vuorio E 1992 Specific hybridization probes for mouse alpha 2(IX) and alpha 1(X) collagen mRNAs. Biochim Biophys Acta 1130:7880.
  • 29
    Linsenmayer TF, Hendrix MJ 1980 Monoclonal antibodies to connective tissue macromolecules: Type II collagen. Biochem Biophys Res Commun 92:440446.
  • 30
    Girkontaite I, Frischholz S, Lammi P, Wagner K, Swoboda B, Aigner T, Von Der Mark K 1996 Immunolocalization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies. Matrix Biol 15:231238.
  • 31
    Eerola I, Uusitalo H, Aro H, Vuorio E 1998 Production of cartilage collagens during metaphyseal bone healing in the mouse. Matrix Biol 17:317320.
  • 32
    Sandberg M, Vuorio E 1987 Localization of types I, II, and III collagen mRNAs in developing human skeletal tissues by in situ hybridization. J Cell Biol 104:10771084.
  • 33
    Yla-Herttuala S, Rosenfeld ME, Parthasarathy S, Glass CK, Sigal E, Witztum JL, Steinberg D 1990 Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions. Proc Natl Acad Sci USA 87:69596963.
  • 34
    De Crombrugghe B, Lefebvre V, Behringer RR, Bi W, Murakami S, Huang W 2000 Transcriptional mechanisms of chondrocyte differentiation. Matrix Biol 19:389394.
  • 35
    Sakano S, Zhu Y, Sandell LJ 1999 Cartilage-derived retinoic acid-sensitive protein and type II collagen expression during fracture healing are potential targets for Sox9 regulation. J Bone Miner Res 14:18911901.
  • 36
    Uusitalo H, Hiltunen A, Ahonen M, Kähäri V-M, Aro HT, Vuorio E 2001 Induction of periosteal callus formation by bone morphogenetic protein-2 employing adenovirus-mediated gene delivery Matrix Biol 20:123127.
  • 37
    Bax BE, Wozney JM, Ashhurst DE 1999 Bone morphogenetic protein-2 increases the rate of callus formation after fracture of the rabbit tibia. Calcif Tissue Int 65:8389.
  • 38
    Baltzer AW, Lattermann C, Whalen JD, Wooley P, Weiss K, Grimm M, Ghivizzani SC, Robbins PD, Evans CH 2000 Genetic enhancement of fracture repair: Healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther 7:734739.
  • 39
    Huang W, Zhou X, Lefebvre V, De Crombrugghe B 2000 Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability To transactivate a col2a1 chondrocyte-specific enhancer. Mol Cell Biol 20:41494158.
  • 40
    Vortkamp A, Pathi S, Peretti GM, Caruso EM, Zaleske DJ, Tabin CJ 1998 Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair. Mech Dev 71:6576.
  • 41
    Ito H, Akiyama H, Shigeno C, Iyama K, Matsuoka H, Nakamura T 1999 Hedgehog signaling molecules in bone marrow cells at the initial stage of fracture repair. Biochem Biophys Res Commun 262:443451.
  • 42
    Ferguson C, Alpern E, Miclau T, Helms JA 1999 Does adult fracture repair recapitulate embryonic skeletal formation? Mech Dev 87:5766.
  • 43
    Zou HY, Wieser R, Massague J, Niswander L 1997 Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev 11:21912203.
  • 44
    Urist MR 1997 Bone morphogenetic protein: The molecularization of skeletal system development. J Bone Miner Res 12:343346.
  • 45
    Kanis JA 1994 Pathogenesis of osteoporosis and fracture. In: KanisJA (ed.) Osteoporosis. Blackwell Science, Oxford, UK, pp. 2255.
  • 46
    Hiltunen A, Aro HT, Vuorio E 1993 Regulation of extracellular matrix genes during fracture healing in mice. Clin Orthop 297:2327.