• 1
    Melton LJ III 1992 Epidemiology of osteoporosis. Trends Endocrinol Metab 3:224229.
  • 2
    Melton LJ III 1993 Hip fractures: A worldwide problem today and tomorrow. Bone 14:S1S8.
  • 3
    Ray NF, Chan JK, Thamer M, Melton LJ III 1997 Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: Report from the National Osteoporosis Foundation. J Bone Miner Res 12:2435.
  • 4
    Genant HK, Cann CE, Ettinger B, Gordan GS 1982 Quantitative computer tomography of vertebral spongiosa: A sensitive method for detecting early bone loss after oophorectomy. Ann Intern Med 97:699705.
  • 5
    Stepan JJ, Lachman M, Zverina J, Pacovsky V 1989 Castrated men exhibit bone loss; effects of calcitonin treatment on biochemical indices of bone remodeling. J Clin Endocrinol Metab 69:523527.
  • 6
    Harman SM, Tsitouras PD 1980 Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin. J Clin Endocrinol Metab 51:3540.
  • 7
    Riggs BL, Wahner HW, Dunn WL, Mazess RB, Offord KP, Melton LJ III 1981 Differential changes in bone mineral density of the appendicular skeleton with aging: Relationship to spinal osteoporosis. J Clin Invest 67:328335.
  • 8
    Jones G, Nguyen T, Sambrook P, Kelly PJ, Eisman JA 1994 Progressive loss of bone in the femoral neck in elderly people: Longitudinal findings from the Dubbo osteoporosis epidemiology study. BMJ 309:691695.
  • 9
    Epstein S, Bryce G, Hinman JW, Miller ON, Riggs BL, Hui SL, Johnston CC Jr 1986 The influence of age on bone mineral regulating hormones. Bone 7:421425.
  • 10
    Khosla S, Melton LJ III, Atkinson EJ, O'Fallon WM, Klee GG, Riggs BL 1998 Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen. J Clin Endocrinol Metab 83:22662274.
  • 11
    Prince R, Dick I, Devine A, Price RI, Gutteridge DH, Kerr D, Criddle A, Garcia-Webb P, St John A 1995 The effects of menopause and age on calcitropic hormones; a cross-sectional study of 655 healthy women aged 35 to 90. J Bone Miner Res 10:835842.
  • 12
    Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS 1994 Estrogen resistance caused by a mutation in the estrogen receptor gene in man. N Engl J Med 331:10561061.
  • 13
    Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K 1995 Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological roll of estrogens. J Clin Endocrinol Metab 80:36893698.
  • 14
    Carani C, Qin K, Simoni M, Faustini-Fustini M, Serpente S, Boyd J, Korach KS, Simpson ER 1997 Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 337:9195.
  • 15
    Bilezikian JP, Morishima A, Bell J, Grumbach MM 1998 Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. N Engl J Med 339:599603.
  • 16
    Slemenda CW, Longcope C, Zhou L, Hui SL, Peacock M, Johnston CC 1997 Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens. J Clin Invest 100:17551759.
  • 17
    Greendale GA, Edelstein S, Barrett-Connor E 1997 Endogenous sex steroids and bone mineral density in older women and men: The Rancho Bernardo study. J Bone Miner Res 12:18331843.
  • 18
    Khosla S, Melton LJ III, Atkinson EJ, O'Fallon WM 2001 Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. J Clin Endocrinol Metab 86:35553561.
  • 19
    Falahati-Nini A, Riggs BL, Atkinson EJ, O'Fallon WM, Eastell R, Khosla S 2000 Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. J Clin Invest 106:15531560.
  • 20
    Sadovsky Y, Adler S 1998 Selective modulation of estrogen receptor action. Clin Endocrinol Metab 83:35.(editorial)
  • 21
    Uebelhart B, Bonjour JP, Draper MW, Pavo I, Basson R, Rizzoli R 2000 Effects of the selective estrogen receptor modulator raloxifene (RLX) on bone metabolism in healthy males. J Bone Miner Res 15:S229.
  • 22
    Broulik PD 1991 Tamoxifen prevents bone loss in ovariectomized mice. Endocr Regul 25:217219.
  • 23
    Li X, Takahashi M, Kushida K, Inoue T 1998 The less potent estrogenic effect of tamoxifen on bone in ovariectomized rats with established osteopenia. Calcif Tissue Int 62:502505.
  • 24
    Love RR, Mazess RB, Barden HS, Epstein S, Newcomb PA, Jordan VC, Carbone PP, Demets DL 1992 Effects of tamoxifene on bone mineral density in postmenopausal women with breast cancer. N Engl J Med 326:852856.
  • 25
    Powles TJ, Hickish T, Kanis JA, Tidy A, Ashley S 1996 Effect of tamoxifen on bone mineral density measured by dual-energy X-ray absorptiometry in healthy premenopausal and postmenopausal women. J Clin Oncol 14:7884.
  • 26
    Burshell AL, Anderson SJ, Leib ES, Johnston CC, Costantino JP 1999 The effect of tamoxifen on pre and postmenopausal bone. J Bone Miner Res 14:S1;S158.
  • 27
    Grey AB, Stapleton JP, Evans MC, Tatnell MA, Ames RW, Reid IR 1995 The effect of the antiestrogen tamoxifen on bone mineral density in normal late postmenopausal women. Am J Med 99:636641.
  • 28
    Draper MW, Flowers DE, Huster WJ, Neild JA, Harper KD, Arnaud C 1996 A controlled trial of raloxifene (LY139481) HCl: Impact on bone turnover and serum lipid profile in healthy postmenopausal women. J Bone Miner Res 11:835842.
  • 29
    Delmas PD, Bjarnason NH, Mitlak BH, Ravoux AC, Shah AS, Huster WJ, Draper M, Christiansen C 1997 Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. N Engl J Med 337:16411647.
  • 30
    Lufkin EG, Whitaker MD, Nickelsen T, Argueta R, Caplan RH, Knickerbocker RK, Riggs BL 1998 Treatment of established postmenopausal osteoporosis with raloxifene: A randomized trial. J Bone Miner Res 13:17471754.
  • 31
    Meunier PJ, Vignot E, Garnero P, Confavreux E, Paris E, Liu-Leage S, Sarkar S, Liu T, Wong M, Draper MW 1999 Treatment of postmenopausal women with osteoporosis or low bone density with raloxifene. Osteoporos Int 10:330336.
  • 32
    Heany RP, Draper MW 1997 Raloxifene and estrogen: Comparative bone-remodeling kinetics. J Clin Endocrinol Metab 82:34253429.
  • 33
    Amin S, Zhang Y, Kiel DP, Sawin CT, Hannan MT, Felson DT 2000 Serum estradiol and the risk for hip fractures in elderly men: The Framingham study. J Bone Miner Res 15:S1;S159.