• 1
    Edwards FA, Gibb AJ, Colquhoun D 1992 ATP receptor-mediated synaptic currents in the central nervous system. Nature 359:144147.
  • 2
    Perregaux D, Gabel CA 1994 Interleukin-1β maturation and release in response to ATP and nigericin. J Biol Chem 21:1519515203.
  • 3
    Chow SC, Kass GEN, Orrenius S 1997 Purines and their role in apoptosis. Neuropharmacology 36:11491156.
  • 4
    Jones SJ, Gray C, Boyde A, Burnstock G 1997 Purinergic transmitters inhibit bone formation by cultured osteoblasts. Bone 21:393399.
  • 5
    Morrison MS, Turin L, King BF, Burnstock G, Arnett TR 1998 ATP is a potent stimulator of the activation and formation of rodent osteoclasts. J Physiol 511:495500.
  • 6
    Burnstock G 1972 Purinergic nerves. Pharmacol Rev 24:509581.
  • 7
    Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M 1994 Nomeclature and classification of purinoceptors. Pharmacol Rev 64:143156.
  • 8
    Suprenant A, Rassendren F, Kawashima E, North RA Buell G 1996 The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science 272:735738.
  • 9
    Cockcroft S, Gomperts BD 1979 ATP induces nucleotide permeability in rat mast cells. Nature 279:541542.
  • 10
    Humphreys BD, Dubyak GR 1996 Induction of the P2Z/P2X7 nucleotide receptor and associated phospholipase D activity by lipopolysaccharide and INFγ in the human THP-1 monocytic cell line. J Immunol 157:56275637.
  • 11
    Ferrari D, Chiozzi P, Falzoni S, Dal Susino M, Melchiorri L, Baricordi OR, Di Virgilio F 1997 Extracellular ATP triggers IL-1β release by activating the purinergic P2Z receptor in human macrophages. J Immunol 159:14511458.
  • 12
    Groschel-Stewart U, Bardini M, Robson T, Burnstock G 1999 Localisation of P2X5 and P2X7 receptors by immunohistochemistry in rat stratified squamous epithelia. Cell Tissue Res 296:599605.
  • 13
    Solini A, Chiozzi P, Morelli A, Fellin R, Di Virgilio F 1999 Human primary fibroblast in vitro express a purinergic P2X(7) receptor counted to ion fluxes, microvesicle formation and IL-6 release. J Cell Sci 112:297305.
  • 14
    DiVirgilio F 1995 The P2Z purinoceptor: An intriguing role in immunity, inflammation and cell death. Immunol Today 16:524528.
  • 15
    Bowler WB, Birch MA, Gallagher JA, Bilbe G 1995 Identification and cloning of human P2U purinoceptor present in osteoclastoma, bone and osteoblasts. J Bone Miner Res 10:11371145.
  • 16
    Weidema AF, Dixon SJ, Sims SM 1998 Extracellular nucleotides activate P2X and P2Y purinoceptors on mammalian osteoclasts. J Dent Res 77:B2178.(meeting abstract)
  • 17
    Bowler WB, Maier R, Bilbe G, Gallagher JA 1998 Osteoblast express multiple G-protein coupled P2Y receptor subtypes. Bone 22:2S.(meeting abstract)
  • 18
    Schöfl C, Cuthbertson KSR, Walsh CA, Mayne C, Cobbold P, Mühlen AVZ, Hesch RD, Gallagher JA 1992 Evidence for P2 receptor on human osteoblast-like cells. J Bone Miner Res 7:485491.
  • 19
    Dixon SJ, Sims SM 2000 P2 purinergic receptors on osteoblasts and osteoclasts: Potential targets for drug development. Drug Dev Res 49:187200.
  • 20
    Grigoriadis AE, Schellander K, Wang ZQ, Wagner EF 1993 Osteoblasts are target cells for transformation in c-fos transgenic mice. J Cell Biol 122:685701.
  • 21
    Hipskind RA, Bilbe G 1998 MAP kinase signaling cascades and gene expression in osteoblasts. Front Biosci 3:D804D816.
  • 22
    Shimegi S 1996 ATP and adenosine act as mitogen for osteoblast-like cells (MC3T3-E1). Calcif Tissue Int 58:108113.
  • 23
    Kaplan AD, Reimer WJ, Feldman RD, Dixon SJ 1995 Extracellular nucleotides potentate the cytosolic Ca2+, but not cyclic adenosine 3′,5′-monophosphate response to parathyroid hormone in rat osteoblastic cells. Endocrinoclogy 136:16741685.
  • 24
    Bowler WB, Dixon CJ, Halleux C, Maier R, Bilbe G, Fraser WD, Gallagher JA, Hipskind RA 1999 Signaling in human osteoblasts by extracellular nucleotides. Their weak induction of the c-fos proto-oncogene via Ca2+ mobilization is strongly potentiated by a parathyroid hormone/cAMP-dependent protein kinase pathway independently of mitogen-activated protein kinase. J Biol Chem 274:1431514324.
  • 25
    Bowler WB, Tattersall JA, Hussein R, Dixon CJ, Cobbold PH, Gallagher JA 1998 Release of ATP by osteoblasts: Modulation by fluid shear forces. Bone 22:3S.(meeting abstract)
  • 26
    Modderman WE, Weidema AF, Vrijheid-Lammers T, Wassenaar AM, Nijweide PJ 1994 Permeabilization of cells of hemopoietic origin by extracellular ATP4−: Elimination of osteoclasts, macrophages, and their precursors from isolated bone cell populations and fetal bone rudiments. Calcif Tissue Int 55:141150.
  • 27
    Gartland A, Ginty AF, Gallagher JA, Bowler WB 1999 Activation of P2X7 receptors expressed by human osteoclastoma modulates bone resorption. Calcif Tissue Int 64(Suppl 1):S56.(meeting abstract)
  • 28
    Gallagher JA, Gundle R, Beresford JN 1996 Isolation and culture of bone-forming cells (osteoblasts) from human bone. In: JonesGE (ed.) Methods in Molecular Medicine: Human Cell Culture Protocols. Humana Press Inc., Totowa, NJ, USA, pp. 233262.
  • 29
    Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156161.
  • 30
    Sambrook J, Fritsch EF, Maniatis T 1989 Plasmid vectors. In: Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, USA, p. 1.21.
  • 31
    Rogers M, Sun M, Lerner MR, Vogt RG 1997 Snmp-1, a novel membrane protein of olfactory neurons of the silk moth Antheraea polyphemus with homology to the CD36 family of membrane proteins. J Biol Chem 272:1479214804.
  • 32
    Buell G, Chessell IP, Michel AD, Collo G, Salazzo M, Herren S, Gretener D, Grahames C, Kaur R, Kosco-Vilbios MH, Humphrey PPA 1998 Blockade of human P2X7 receptor function with a monoclonal antibody. Blood 92:35213528.
  • 33
    Chessell IP, Michel AD, Humphrey PPA 1998 Effects of antagonists at the human recombinant P2X7 receptor. Br J Pharmacol 124:13141320.
  • 34
    Dixon CJ, Bowler WB, Walsh CA, Gallagher JA 1997 Effects of extracellular nucleotides on single cells and populations of human osteoblasts: Contribution of cell heterogeneity to relative potencies. Br J Pharmacol 120:777780.
  • 35
    Schulze-Lohoff E, Hugo C, Rost S, Arnold S, Gruber A, Brüne B, Bernd Sterzel R 1998 Extracellular ATP causes apoptosis and necrosis of cultured mesangial cells via P2Z/P2X7 receptors. Am J Physiol 275:F692F971.
  • 36
    Chessell IP, Michel AD, Humphrey PPA 1997 Properties of the pore forming P2X7 purinoceptor in mouse NTW8 microglial cells. Br J Pharmacol 121:14291437.
  • 37
    Petrou S, Ugur M, Drummond RM, Singer JJ, Walsh JV 1997 P2X7 purinoceptor expression in Xenopus oocytes is not sufficient to produce a pore-forming P2Z-like phenotype. FEBS Lett 411:339345.
  • 38
    Fernando KC, Gargett CE Wiley JS 1999 Activation of the P2Z/P2X7 receptor in human lymphocytes produces a delayed permeability lesion: Involvement of phospholipase D. Arch Biochem Biophys 362:197202.
  • 39
    Gallagher JA, Dillon JP 1997 Bone remodeling. In: DulbeccoR (ed.) Encyclopedia of Human Biology, 2nd ed., vol. 2. Academic Press, San Diego, CA, USA, pp. 135149.
  • 40
    Steller H 1995 Mechanisms and genes of cellular suicide. Science 267:14451449.
  • 41
    Jilka RL, Weinstein RS, Bellido T, Parfitt AM, Manolagas SC 1998 Osteoblast programmed cell death (apoptosis): Modulation by growth factors and cytokines. J Bone Miner Res 13:793802.