• 1
    Blair HC, Kahn AJ, Crouch EC, Jeffrey JJ, Teitelbaum SL 1986 Isolated osteoclasts resorb the organic and inorganic components of bone. J Cell Biol 102:11641172.
  • 2
    Sundquist K, Lakkakorpi P, Wallmark B, Vaananen K 1990 Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption. Biochem Biophys Res Commun 168:309313.
  • 3
    Vaes G 1968 On the mechanisms of bone resorption. The action of parathyroid hormone on the excretion and synthesis of lysosomal enzymes and on the extracellular release of acid by bone cells. J Cell Biol 39:676697.
  • 4
    Baron R, Neff L, Louvard D, Courtoy PJ 1985 Cell-mediated extracellular acidification and bone resorption: Evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border. J Cell Biol 101:22102222.
  • 5
    Blair HC, Schlesinger PH 1992 The mechanism of osteoclast acidification. In: RifkinBR, GayCV (eds.) Biology and Physiology of the Osteoclast. CRC Press, Boca Raton, FL, USA, pp. 259287.
  • 6
    Li YP, Chen W, Liang Y, Li E, Stashenko P 1999 Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet 23:447451.
  • 7
    Li YP, Chen W, Stashenko P 1996 Molecular cloning and characterization of a putative novel human osteoclast-specific 116-kDa vacuolar proton pump subunit. Biochem Biophys Res Commun 218:813821.
  • 8
    Sambrook J, Fritsch EF, Maniatis T 1989 Molecular Cloning: A Laboratory Manual, 2nd ed, Cold Spring Harbor Laboratory Press, New York, NY, USA.
  • 9
    Chen W, Li YP 1998 Generation of mouse osteoclastogenic cell lines immortalized with SV40 large T antigen. J Bone Miner Res 13:11121123.
  • 10
    Li YP, Chen W, Stashenko P 1995 Characterization of a silencer element in the first exon of the human osteocalcin gene. Nucleic Acids Res 23:50645072.
  • 11
    Feng ZM, Li YP, Chen CL 1989 Analysis of the 5′-flanking regions of rat inhibin alpha- and beta-B-subunit genes suggests two different regulatory mechanisms. Mol Endocrinol 3:19141925.
  • 12
    Li YP, Chen W 1999 Characterization of mouse cathepsin K gene, the gene promoter, and the gene expression. J Bone Miner Res 14:487499.
  • 13
    Wilkinson DG 1993 In situ hybridization. In: SternCD, HollandPWH (eds.) Essential Developmental Biology: A Practical Approach. IRL Press, Oxford, UK, pp. 257274.
  • 14
    Grigoriadis AE, Wang ZQ, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EF 1994 c-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266:443448.
  • 15
    Iotsova V, Caamano J, Loy J, Yang Y, Lewin A, Bravo R 1997 Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med 3:12851289.
  • 16
    Tondravi MM, McKercher SR, Anderson K, Erdmann JM, Quiroz M, Maki R, Teitelbaum SL 1997 Osteopetrosis in mice lacking haematopoietic transcription factor PU1. Nature 386:8184.
  • 17
    Mattsson JP, Schlesinger PH, Keeling DJ, Teitelbaum SL, Stone DK, Xie XS 1994 Isolation and reconstitution of a vacuolar-type proton pump of osteoclast membranes. J Biol Chem 269:2497924982.
  • 18
    Fischer A, Griscelli C, Friedrich W, Kubanek B, Levinsky R, Morgan G, Vossen J, Wagemaker G, Landais P 1986 Bone-marrow transplantation for immunodeficiencies and osteopetrosis: European survey, 1968-1985. Lancet 2:10801084.
  • 19
    Gerritsen EJ, Vossen JM, Van Loo IH, Hermans J, Helfrich MH, Griscelli C, Fischer A 1994 Autosomal recessive osteopetrosis: Variability of findings at diagnosis and during the natural course. Pediatrics 93:247253.
  • 20
    Toyomura T, Oka T, Yamaguchi C, Wada Y, Futai M 2000 Three subunit a isoforms of mouse vacuolar H(+)-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation. J Biol Chem 275:87608765.
  • 21
    Nishi T, Forgac M 2000 Molecular cloning and expression of three isoforms of the 100-kDa subunit of the mouse vacuolar proton-translocating ATPase. J Biol Chem 275:68246830.
  • 22
    Mattsson JP, Li X, Peng SB, Nilsson F, Andersen P, Lundberg LG, Stone DK, Keeling DJ 2000 Properties of three isoforms of the 116-kDa subunit of vacuolar H+-ATPase from a single vertebrate species. Cloning, gene expression and protein characterization of functionally distinct isoforms in Gallus gallus. Eur J Biochem 267:41154126.
  • 23
    Gum R, Lengyel E, Juarez J, Chen JH, Sato H, Seiki M, Boyd D 1996 Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences. J Biol Chem 271:1067210680.
  • 24
    Wucherpfennig AL, Li YP, Stetler-Stevenson WG, Rosenberg AE, Stashenko P 1994 Expression of 92 kD type IV collagenase/gelatinase B in human osteoclasts. J Bone Miner Res 9:549556.
  • 25
    Manolagas SC, Bellido T, Jilka RL 1995 New insights into the cellular, biochemical, and molecular basis of postmenopausal and senile osteoporosis: Roles of IL-6 and gp130. Int J Immunopharmacol 17:109116.
  • 26
    Udagawa N, Takahashi N, Katagiri T, Tamura T, Wada S, Findlay DM, Martin TJ, Hirota H, Taga T, Kishimoto T 1995 Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J Exp Med 182:14611468.