• Please log in or register to access this feature.

Letter

You have full text access to this OnlineOpen article

Absence of Evidence Is Not Evidence of Absence; Redundancy Blocks Determination of Cause and Effect

  1. Chantal Chenu,
  2. Cécile Itzstein,
  3. Léon Espinosa

Article first published online: 1 SEP 2001

DOI: 10.1359/jbmr.2001.16.9.1728

Issue

Journal of Bone and Mineral Research

Journal of Bone and Mineral Research

Volume 16, Issue 9, pages 1728–1729, September 2001

Additional Information

How to Cite

Chenu, C., Itzstein, C. and Espinosa, L. (2001), Absence of Evidence Is Not Evidence of Absence; Redundancy Blocks Determination of Cause and Effect. J Bone Miner Res, 16: 1728–1729. doi: 10.1359/jbmr.2001.16.9.1728

Author Information

  1. INSERM Unit 403, Hôpital E. Herriot, 69437 Lyon Cedex 03, France

Publication History

  1. Issue published online: 2 DEC 2009
  2. Article first published online: 1 SEP 2001

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (20K)

REFERENCES

  • 1
    Gray C, Marie H, Aroba M, Tanaka K, Boyde A, Jones S, Attwell D 2001 Glutamate does not play a major role in controlling bone growth. J Bone Miner Res 16:742–749.
  • 2
    Mason DJ, Suva LJ, Genever PG, Patton AJ, Steuckle S, Hillam RA, Skerry TM 1997 Mechanically regulated expression of a neural glutamate transporter in bone: A role for excitatory amino acids as osteotropic agents? Bone 20:199–205.
  • 3
    Chenu C, Serre CM, Raynal C, Burt-Pichat B, Delmas PD 1998 Glutamate receptors are expressed by bone cells and are involved in bone resorption. Bone 22:295–299.
  • 4
    Patton AJ, Genever PG, Birch MA, Suva LJ, Skerry TM 1998 Expression of N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggests a novel glutamate signaling pathway in bone. Bone 22:645–649.
  • 5
    Espinosa L, Itzstein C, Cheynel H, Delmas PD, Chenu C 1999 Active NMDA glutamate receptors are expressed by mammalian osteoclasts. J Physiol 518:47–53.
  • 6
    Laketic-Ljubojevic I, Suva LJ, Maathuis FJM, Sanders D, Skerry TM 1999 Functional characterization of N-methyl-D-aspartic acid-gated channels in bone cells. Bone 25:631–638.
  • 7
    Peet NM, Grabowski PS, Laketic-Ljubojevic I, Skerry TM 1999 The glutamate receptor antagonist MK801 modulates bone resorption in vitro by a mechanism predominantly involving osteoclast differentiation. FASEB J 13:2179–2185.
  • 8
    Itzstein C, Espinosa L, Delmas PD, Chenu C 2000 Specific antagonists of NMDA receptors prevent osteoclast sealing zone formation required for bone resorption. Biochem Biophys Res Commun 268:201–209.
  • 9
    Gu Y, Publicover S 2000 Expression of functional metabotropic glutamate receptors in primary cultured rat osteoblasts. J Biol Chem 275:34252–34259.
  • 10
    Malaval L, Liu F, Roche P, Aubin JE 1999 Kinetics of osteoprogenitor proliferation and osteoblast differentiation in vitro. J Cell Biochem 74:616–627.
  • 11
    Dobson KR, Skerry TM 2000 The NMDA-type glutamate receptor antagonist MK801 regulates differentiation of rat bone marrow osteoprogenitors and influences adipogenesis. J Bone Miner Res 15:S1.;S272
  • 12
    Itzstein C, Cheynel H, Burt-Pichat B, Merle B, Espinosa L, Delmas PD, Chenu C 2001 Molecular identification of NMDA glutamate receptors expressed in bone cells. J Cell Biochem 82:134–144.
  • 13
    Yoshitake H, Rittling SR, Denhardt DT, Noda M 1999 Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Proc Natl Acad Sci USA 96:8156–8160.
View Full Article (HTML) Get PDF (20K)