• 1
    Puzas JE, Ishibe M 1992 Osteoblast/osteoclast coupling. In: RifkinBR, GayCV (eds.) Biology and Physiology of the Osteoclast. CRC Press, Boca Raton, FL, USA, pp. 337356.
  • 2
    Suda T, Nakamura I, Jimi E, Takahashi N 1997 Regulation of osteoclast function. J Bone Miner Res 12:869879.
  • 3
    Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL 2000 The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res 15:212.
  • 4
    Lerner UH 2000 Osteoclast formation and resorption. Matrix Biol 19:107120.
  • 5
    Chambers TJ, Fuller K 1985 Bone cells predispose bone surfaces to resorption by exposure of mineral to osteoclastic contact. J Cell Sci 76:155165.
  • 6
    Chambers TJ, Darby JA, Fuller K 1985 Mammalian collagenase predisposes bone surfaces to osteoclastic resorption. Cell Tissue Res 241:671675.
  • 7
    Harris WH, Heaney RP 1969 Skeletal renewal and metabolic bone diseases. N Engl J Med 280:193202, 253–259, 303–311.
  • 8
    Kahn AJ, Partridge NC 1987 New concepts in bone remodeling: An expanding role for the osteoblast. Am J Otolaryngol 8:258264.
  • 9
    Martin TJ, Ng KW 1994 Mechanisms by which cells of the osteoblast lineage control osteoclast formation and activity. J Cell Biochem 56:357366.
  • 10
    Rodan GA 1997 Mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption. J Bone Miner Res 6:527530.
  • 11
    Jones SJ, Gray C, Boyde A 1994 Simulation of bone resorption-repair coupling in vitro. Anat Embryol 190:339349.
  • 12
    Pfeilschifter J, Wolf O, Naumann A, Minne HW, Mundy GR, Ziegler R 1990 Chemotactic response of osteoblast-like cells to transforming growth factor β. J Bone Miner Res 5:825830.
  • 13
    Oursler MJ 1994 Osteoblast synthesis and secretion and activation of latent transforming growth factor β. J Bone Miner Res 9:443452.
  • 14
    Erlebacher A, Filvaroff EH, Ye JQ, Derynck R 1998 Osteoblastic responses to TGF-beta during bone remodeling. Mol Biol Cell 9:19031918.
  • 15
    Hayden JM, Mohan S, Baylink DJ 1995 The insulin-like growth factor system and the coupling of formation to resorption. Bone 17:93S98S.
  • 16
    Dodds RA, Connor JR, James IE, Rykaczewski EL, Appelbaum E, Dul E, Gowen M 1995 Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: An in vitro and ex vivo study of remodeling. J Bone Miner Res 10:16661680.
  • 17
    Tran Van P, Vignery A, Baron R 1982 An electron microscopic study of the bone-remodeling sequence in the rat. Cell Tissue Res 225:283292.
  • 18
    Jones SJ, Boyde A, Ali NN 1986 The interface of cells and their matrices in mineralized tissues: A review. Scanning Electron Microsc 4:15551569.
  • 19
    Delaissé JM, Boyde A, Maconnachie E, Ali NN, Sear CHJ, Eeckhout Y, Vaes G, Jones SJ 1987 The effects of inhibitors of cysteine-proteinases and collagenase on the resorptive activity of isolated osteoclasts. Bone 8:305313.
  • 20
    De Saint Georges L, Miller SC, Bowman BM, Jee WSS 1988 Ultrastructural features of osteoclasts in situ. Scanning Microsc 3:12011206.
  • 21
    Holliday LS, Welgus HG, Fliszar CJ, Veith GM, Jeffrey JJ, Gluck SL 1997 Initiation of osteoclast bone resorption by interstitial collagenase. J Biol Chem 272:2205322058.
  • 22
    Heersche JNM 1978 Mechanism of osteoclastic bone resorption: A new hypothesis. Calcif Tissue Res 26:8184.
  • 23
    Rifkin BR, Heijl L 1979 The occurrence of mononuclear cells at sites of osteoclastic bone resorption in experimental periodontitis. J Periodontol 50:636640.
  • 24
    Takahashi T, Kurihara N, Takahashi K, Kumegawa M 1986 An ultrastructural study of phagocytosis in bone by osteoblastic cells from fetal mouse calvaria in vitro. Arch Oral Biol 31:703706.
  • 25
    Everts V, Aronson DC, Beertsen W 1985 Phagocytosis of bone collagen by osteoclasts in two cases of pycnodysostosis. Calcif Tissue Int 37:2531.
  • 26
    Saftig P, Hunziker E, Wehmeyer O, Jones S, Boyde A, Rommerskirch W, Moritz JD, Schu P, VonFigura K 1998 Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin K-deficient mice. Proc Natl Acad Sci USA 95:1345313458.
  • 27
    Delaissé JM, Eeckhout Y, Sear C, Galloway A, McCullagh K, Vaes G 1985 A new synthetic inhibitor of mammalian tissue collagenase inhibits bone resorption in culture. Biochem Biophys Res Commun 133:483490.
  • 28
    Delaissé JM, Vaes G 1992 Mechanism of mineral solubilization and matrix degradation in osteoclastic bone resorption. In: RifkinBR, GayCV (eds.) Biology and Physiology of the Osteoclast. CRC Press, Boca Raton, FL, USA, pp. 289314.
  • 29
    Everts V, Delaissé JM, Korper W, Niehof A, Vaes A, Beertsen W 1992 Degradation of collagen in the bone-resorbing compartment underlying the osteoclast involves both cysteine-proteinases and matrix metalloproteinases. J Cell Physiol 150:221231.
  • 30
    McKee MD, Nanci A 1996 Osteopontin at mineralized tissue interfaces in bone, teeth and osseointegrated implants: Ultrastructural distribution and implications for mineralized tissue formation, turnover, and repair. Microsc Res Technol 33:141164.
  • 31
    Van Noorden CJF, Jonges GN 1987 Quantification of the histochemical reaction for alkaline phosphatase using the indoxyl-tetranitro BT method. Histochem J 19:94102.
  • 32
    Groeneveld MC, Everts V, Beertsen W 1993 A quantitative enzyme histochemical analysis of the distribution of alkaline phosphatase activity in the periodontal ligament of the rat incisor. J Dent Res 72:13441350.
  • 33
    Miller SC, Jee WSS 1987 The bone lining cell: A distinct phenotype? Calcif Tissue Int 41:15.
  • 34
    Tanaka Y, Maruo A, Fuji K, Nomi M, Nakamura T, Eto S, Minami Y 2000 Intercellular adhesion molecule 1 discriminates functionally different populations of human osteoblasts: Characteristic involvement of cell cycle regulators. J Bone Miner Res 15:19121923.
  • 35
    Everts V, Delaissé JM, Korper W, Beertsen W 1998 Cysteine proteinases and matrix metalloproteinases play distinct roles in the subosteoclastic resorption zone. J Bone Miner Res 13:14201430.
  • 36
    Gowen M, Lazner F, Dodds R, Kapadia R, Field J, Tavaria M, Bertoncello I, Drake F, Zavarselk S, Tellis I, Hertzog P, Debouck C, Kola I 1999 Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization. J Bone Miner Res 14:16541663.
  • 37
    Gelb BD, Shi GP, Chapman HA, Desnick RJ 1996 Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 273:12361238.
  • 38
    Garant PR 1976 Collagen resorption by fibroblasts. A theory of fibroblastic maintenance of the periodontal ligament. J Periodontol 47:380390.
  • 39
    Beertsen W, Brekelmans M, Everts V 1978 The site of collagen resorption in the periodontal ligament of the rodent molar. Anat Rec 192:305318.
  • 40
    Yajima T, Sakakura Y, Tsuruga E, Hirai T, Ikeda Y, Fujii S, Shide N 1999 Collagen-phagocytosing ability of periodontal osteoblasts at the bone surface. Arch Histol Cytol 62:1725.
  • 41
    Guenther HL, Hofstetter W, Stutzer A, Muhlbauer R, Fleisch H 1989 Evidence for heterogeneity of the osteoblastic phenotype determined with clonal rat bone cells established from transforming growth factor-beta-induced cell colonies grown anchorage independently in semisolid medium. Endocrinology 125:20922102.
  • 42
    Liu F, Malaval L, Aubin JE 1997 The mature osteoblast phenotype is characterized by extensive plasticity. Exp Cell Res 10:97105.
  • 43
    Aimes RT, Quigley JP 1995 Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments. J Biol Chem 270:58725876.
  • 44
    D'Ortho MP, Stanton H, Butler M, Atkinson SJ, Murphy G, Hembry RM 1998 MT1-MMP on the cell surface causes focal degradation of gelatin films. FEBS Lett 421:159164.
  • 45
    Delaissé JM, Eeckhout Y, Neff L, Francois-Gillet Ch, Henriet P, Su Y, Vaes G, Baron R 1993 (Pro)collagenase (matrix metalloproteinase-1) is present in rodent osteoclasts and in the underlying bone-resorbing compartment. J Cell Sci 106:10711082.
  • 46
    Daci E, Udagawa N, Martin TJ, Bouillon R, Carmeliet G 1999 The role of the plasminogen system in bone resorption in vitro. J Bone Miner Res 14:946952.
  • 47
    Everts V, VanderZee E, Creemers L, Beertsen W 1996 Phagocytosis and intracellular digestion of collagen: Its role in turnover and remodelling. Histochem J 28:229245.
  • 48
    Everts V, Beertsen W, Tigchelaar-Gutter W 1985 The digestion of phagocytosed collagen is inhibited by the proteinase inhibitors leupeptin and E-64. Collagen Relat Res 5:315336.
  • 49
    Van Noorden CJF, Everts V 1991 Selective inhibition of cysteine proteinases by Z-Phe-AlaCH2F suppresses digestion of collagen by fibroblasts and osteoclasts. Biochem Biophys Res Commun 178:178184.
  • 50
    Creemers LB, Hoeben KA, Jansen DC, Buttle DJ, Beertsen W, Everts V 1998 Participation of intracellular cysteine proteinases, in particular cathepsin B, in degradation of collagen in periosteal tissue explants. Matrix Biol 16:575584.
  • 51
    Jilka JL, Hamilton JW 1984 Involvement of nonosteoclastic cells in hormone-regulated collagenolysis in bone. In: CohnDV, FujitaT, PottsJT, TalmageRV (eds.) Endocrine Control of Bone and Calcium Metabolism. Elsevier Science, Amsterdam, The Netherlands, pp. 136138.
  • 52
    Jilka RL, Hamilton JW 1985 Evidence for two pathways for stimulation of collagenolysis in bone. Calcif Tissue Int 37:300306.
  • 53
    Shen X, Roberts E, Peel SAF, Davies JE 1993 Organic extracellular matrix components at the bone cell/substratum interface. Cell Mater 3:257272.
  • 54
    Mundy GR, Boyce B, Hughes D, Wright K, Bonewald L, Dallas S, Harris S, Ghosh-Choudhury N, Chen N, Dunstan C, Izbicka E, Yoneda T 1995 The effects of cytokines and growth factors on osteoblastic cells. Bone 17:71S75S.
  • 55
    Delaissé JM, Eeckhout Y, Vaes G 1988 Bone-resorption agents affect the production and distribution of procollagenase as well as the activity of collagenase in bone tissue. Endocrinology 123:264276.
  • 56
    Bord S, Horner A, Hembry RM, Reynolds JJ, Compston JE 1996 Production of collagenase by human osteoblasts and osteoclasts in vivo. Bone 19:3540.
  • 57
    Meikle MC, Bord S, Hembry RM, Compston J, Croucher PI, Reynolds JJ 1992 Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines. J Cell Sci 103:10931099.
  • 58
    Everts V, Korper W, Jansen DC, Steinfort J, Lammerse I, Heera S, Docherty AJP, Beertsen W 1999 Functional heterogeneity of osteoclasts: Matrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone. FASEB J 13:12191230.