• 1
    Lukert B 1996 Glucocorticoid-induced osteoporosis. In: MarcusR (ed.) Osteoporosis. Academic Press, San Diego, CA, USA, pp. 801820.
  • 2
    Dykman TR, Gluck OS, Murphy WA, Hahn TJ, Hahn BH 1985 Evaluation of factors associated with glucocorticoid-induced osteopenia in patients with rheumatic diseases. Arthritis Rheum 28:361368.
  • 3
    Eastell R, Reid D, Compston J, Cooper C, Fogelman I, Francis R, Hosking D, Purdie D, Ralston S, Reeve J, Russell R, Stevenson J, Torgerson D 1998 A UK consensus group on management of glucocorticoid-induced osteoporosis: An update. J Intern Med 244:271292.
  • 4
    Van Staa TP, Leufkens HG, Abenhaim L, Zhang B, Cooper C 2000 Use of oral corticosteroids and risk of fractures. J Bone Miner Res 15:9931000.
  • 5
    Tannirandorn P, Epstein S 2000 Drug-induced bone loss. Osteoporos Int 11:637659.
  • 6
    Lukert B, Kream B 1996 Clinical and basic aspects of glucocorticoid action. In: BilezikianJP, RaiszLG, RodanCA (eds.) Bone Principles of Bone Biology. Academic Press, San Diego, CA, USA, pp. 533548.
  • 7
    Manolagas SC, Weinstein RS 1999 New developments in the pathogenesis and treatment of steroid-induced osteoporosis. J Bone Miner Res 14:10611066. (editorial)
  • 8
    Lane NE, Lukert B 1998 The science and therapy of glucocorticoid-induced bone loss. Endocrinol Metab Clin North Am 27:465483.
  • 9
    Kostenszky K, Olah E 1974 Effect of prednisolone on callus formation. Acta Biol Hung 25:4960.
  • 10
    Waters RV, Gamradt SC, Asnis P, Vickery BH, Avnur Z, Hill E, Bostrom M 2000 Systemic corticosteroids inhibit bone healing in a rabbit ulnar osteotomy model. Acta Orthop Scand 71:316321.
  • 11
    Bostrom MP, Gamradt SC, Asnis P, Vickery BH, Hill E, Avnur Z, Waters RV 2000 Parathyroid hormone-related protein analog RS-66271 is an effective therapy for impaired bone healing in rabbits on corticosteroid therapy. Bone 26:437442.
  • 12
    Abu EO, Horner A, Kusec V, Triffitt JT, Compston JE 2000 The localization of the functional glucocorticoid receptor alpha in human bone. J Clin Endocrinol Metab 85:883889.
  • 13
    Rosen V, Cox K, Hattersly G 1996 Bone morphogenetic proteins. In: BilezikianJP, RaiszLG, RodanCA (eds.) Principles of Bone Biology. Academic Press, San Diego, CA, USA, pp. 661671.
  • 14
    Abe E, Yamamoto M, Taguchi Y, Lecka-Czernik B, O'Brien CA, Economides AN, Stahl N, Jilka RL, Manolagas SC 2000 Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: Antagonism by noggin. J Bone Miner Res 15:663673.
  • 15
    Bostrom MP, Lane JM, Berberian WS, Missri AA, Tomin E, Weiland A, Doty SB, Glaser D, Rosen VM 1995 Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing. J Orthop Res 13:357367.
  • 16
    Onishi T, Ishidou Y, Nagamine T, Yone K, Imamura T, Kato M, Sampath TK, ten Dijke P, Sakou T 1998 Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats. Bone 22:605612.
  • 17
    Rosen V, Wozney J 2000 Bone morphogenetic proteins and the adult skeleton. In: CanalisE (ed.) Skeletal Growth Factors. Lippincott Williams & Wilkins, Philadelphia, PA, USA, pp. 299310.
  • 18
    Gerhart TN, Kirker-Head CA, Kriz MJ, Holtrop ME, Hennig GE, Hipp J, Schelling SH, Wang E 1993 Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop: 317326.
  • 19
    Yasko AW, Lane JM, Fellinger EJ, Rosen V, Wozney JM, Wang EA 1992 The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats. J Bone Joint Surg Am 74:659670.
  • 20
    Bostrom M, Lane J, Tomin E, Browne M, Berberian W, Turek T, Smith J, Wozney J, Schildhauer T 1996 Use of bone morphogenetic protein-2 in the rabbit ulnar nonunion model. Clin Orthop 327:272282.
  • 21
    Bax BE, Wozney JM, Ashhurst DE 1999 Bone morphogenetic protein-2 increases the rate of callus formation after fracture of the rabbit tibia. Calcif Tissue Int 65:8389.
  • 22
    Welch RD, Jones AL, Bucholz RW, Reinert CM, Tjia JS, Pierce WA, Wozney JM, Li XJ 1998 Effect of recombinant human bone morphogenetic protein-2 on fracture healing in a goat tibial fracture model. J Bone Miner Res 13:14831490.
  • 23
    Bouxsein M, Turek T, Blake C, Seeherman H, Wozney J 2001 Recombinant human bone morphogenetic protein-2 enhances healing in a rabbit ulnar osteotomy model. J Bone Joint Surg Am 83:12191230.
  • 24
    Rickard DJ, Sullivan TA, Shenker BJ, Leboy PS, Kazhdan I 1994 Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev Biol 161:218228.
  • 25
    Boden SD, McCuaig K, Hair G, Racine M, Titus L, Wozney JM, Nanes MS 1996 Differential effects and glucocorticoid potentiation of bone morphogenetic protein action during rat osteoblast differentiation in vitro. Endocrinology 137:34013407.
  • 26
    Centrella M, Rosen V, Wozney JM, Casinghino SR, McCarthy TL 1997 Opposing effects by glucocorticoid and bone morphogenetic protein-2 in fetal rat bone cell cultures. J Cell Biochem 67:528540.
  • 27
    Waters R, Vickery B, Avnur Z, Hirano T, Burr D 1997 Bone structure and turnover following treatment of glucocorticoid osteopenia in rabbits with RS-66271 abd bPTH(1–34). J Bone Miner Res 12:S512.
  • 28
    Schenk R, Olah A, Herrman W 1984 Preparation of calcified tissues for light microscopy. In: DicksonG (ed.) Methods of Calcified Tissue Preparation. Elsevier Science Publication, New York, NY, USA, pp. 142.
  • 29
    Parfitt A, Drezner M, Glorieux F, Kanis J, Recker R 1987 Bone histomorphometry: Standardization of nomenclature, symbols and units. J Bone Miner Res 2:595610.
  • 30
    White AA, Panjabi MM, Southwick WO 1977 The four biomechanical stages of fracture repair. J Bone Joint Surg Am 59:188192.
  • 31
    Ebling W, Szefler S, Jusko W 1985 Methylprednisolone disposition in rabbits: Analysis, prodrug conversion, reversible metabolism, and comparison with man. Drug Metab Dispos 13:296304.
  • 32
    Ferry JJ, Horvath AM, Bekersky I, Heath EC, Ryan CF, Colburn WA 1988 Relative and absolute bioavailability of prednisone and prednisolone after separate oral and intravenous doses. J Clin Pharmacol 28:8187.
  • 33
    Georgitis JW, Flesher KA, Szefler SJ 1982 Bioavailability assessment of a liquid prednisone preparation. J Allergy Clin Immunol 70:243247.
  • 34
    Nishimura J, Ikuyama S 2000 Glucocorticoid-induced osteoporosis: Pathogenesis and management. J Bone Miner Metab 18:350352.
  • 35
    Blunt J, Plotz C, Lattes R, Howes E, Meyer K, Ragan C 1950 Effect of cortisone on experimental fractures in the rabbit. Proc Soc Exp Biol 73:678681.
  • 36
    Sissons H, Hadfield G 1951 The influence of cortisone on the repair of experimental fractures in the rabbit. Br J Surg 39:172178.
  • 37
    Ishida Y, Heersche JN 1998 Glucocorticoid-induced osteoporosis: Both in vivo and in vitro concentrations of glucocorticoids higher than physiological levels attenuate osteoblast differentiation. J Bone Miner Res 13:18221826.
  • 38
    Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC 1998 Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest 102:274282.
  • 39
    Weinstein RS, Nicholas RW, Manolagas SC 2000 Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip. J Clin Endocrinol Metab 85:29072912.
  • 40
    Chang DJ, Ji C, Kim KK, Casinghino S, McCarthy TL, Centrella M 1998 Reduction in transforming growth factor beta receptor I expression and transcription factor CBFa1 on bone cells by glucocorticoid. J Biol Chem 273:48924896.
  • 41
    Delany AM, Canalis E 1995 Transcriptional repression of insulin-like growth factor I by glucocorticoids in rat bone cells. Endocrinology 136:47764781.
  • 42
    Delany AM, Gabbitas BY, Canalis E 1995 Cortisol downregulates osteoblast alpha 1 (I) procollagen mRNA by transcriptional and posttranscriptional mechanisms. J Cell Biochem 57:488494.
  • 43
    Kasperk C, Schneider U, Sommer U, Niethard F, Ziegler R 1995 Differential effects of glucocorticoids on human osteoblastic cell metabolism in vitro. Calcif Tissue Int 57:120126.
  • 44
    McCarthy TL, Centrella M, Canalis E 1990 Cortisol inhibits the synthesis of insulin-like growth factor-I in skeletal cells. Endocrinology 126:15691575.
  • 45
    Swolin D, Brantsing C, Matejka G, Ohlsson C 1996 Cortisol decreases IGF-I mRNA levels in human osteoblast-like cells. J Endocrinol 149:397403.
  • 46
    Smith E, Redman RA, Logg CR, Coetzee GA, Kasahara N, Frenkel B 2000 Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes. J Biol Chem 275:1999220001.
  • 47
    Einhorn TA 1998 The cell and molecular biology of fracture healing. Clin Orthop S7S21.
  • 48
    Bostrom MP 1998 Expression of bone morphogenetic proteins in fracture healing. Clin Orthop S116S123.
  • 49
    Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G 1997 Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 89:747754.
  • 50
    Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T 1997 Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755764.