• 1
    Riggs BL, Melton LJ 1986 Involutional osteoporosis. N Engl J Med 314:16761686.
  • 2
    Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM 1995 Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 332:767773.
  • 3
    Liberman UA, Weiss SR, Broll J, Minne HW, Quan H, Bell NH, Rodriquez-Portales J, Downs RW, Dequeker J, Favus M 1995 Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III osteoporosis treatment study group. N Engl J Med 333:14371443.
  • 4
    NIAMS 2000 Bone biology and bone diseases research: Strategic plan (FY 2000–2004).
  • 5
    Rubin CT, Lanyon LE 1985 Regulation of bone mass by mechanical strain magnitude. Calcif Tissue Int 37:411417.
  • 6
    Turner CH, Forwood MR, Rho JY, Yoshikawa T 1994 Mechanical loading thresholds for lamellar and woven bone formation. J Bone Miner Res 9:8797.
  • 7
    O'Connor JA, Lanyon LE, MacFie H 1982 The influence of strain rate on adaptive bone remodelling. J Biomech 15:767781.
  • 8
    Fuchs RK, Bauer JJ, Snow CM 2001 Jumping improves hip and lumbar spine bone mass in prepubescent children: A randomized controlled trial. J Bone Miner Res 16:148156.
  • 9
    Gross TS, Edwards JL, McLeod KJ, Rubin CT 1997 Strain gradients correlate with sites of periosteal bone formation. J Bone Miner Res 12:982988.
  • 10
    Judex S, Gross TS, Zernicke RF 1997 Strain gradients correlate with sites of exercise-induced bone-forming surfaces in the adult skeleton. J Bone Miner Res 12:17371745.
  • 11
    Damien E, Price JS, Lanyon LE 2000 Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females. J Bone Miner Res 15:21692177.
  • 12
    McDonald F, Somasundaram B, McCann TJ, Mason WT, Meikle MC 1996 Calcium waves in fluid flow stimulated osteoblasts are G protein mediated. Arch Biochem Biophys 326:3138.
  • 13
    You J, Yellowley CE, Donahue HJ, Zhang Y, Chen Q, Jacobs CR 2000 Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow. J Biomech Eng 122:387393.
  • 14
    Prince RL, Smith M, Dick IM, Price RI, Webb PG, Henderson NK, Harris MM 1991 Prevention of postmenopausal osteoporosis. A comparative study of exercise, calcium supplementation, and hormone-replacement therapy. N Engl J Med 325:11891195.
  • 15
    Pruitt LA, Taaffe DR, Marcus R 1995 Effects of a one-year high-intensity versus low-intensity resistance training program on bone mineral density in older women. J Bone Miner Res 10:17881795.
  • 16
    Onoe Y, Miyaura C, Ito M, Ohta H, Nozawa S, Suda T 2000 Comparative effects of estrogen and raloxifene on B lymphopoiesis and bone loss induced by sex steroid deficiency in mice. J Bone Miner Res 15:541549.
  • 17
    Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC, Bellido T 1999 Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J Clin Invest 104:13631374.
  • 18
    Akhter MP, Cullen DM, Pedersen EA, Kimmel DB, Recker RR 1998 Bone response to in vivo mechanical loading in two breeds of mice. Calcif Tissue Int 63:442449.
  • 19
    Fritton JC, Myers ER, van der Meulen MCH, Bostrom MPG, Wright TM 2001 Validation of a loading apparatus: Characterization of murine tibial surface strains in vivo. Trans 47th Orthop Res Soc 26:535.
  • 20
    Brodt MD, Ellis CB, Silva MJ 1999 Growing C57Bl/6 mice increase whole bone mechanical properties by increasing geometric and material properties. J Bone Miner Res 14:21592166.
  • 21
    Rybicki EF, Mills EJ 1977 In vivo and analytical studies of forces and moments in equine long bones. J Biomech 10:701705.
  • 22
    Bain SD, Impeduglia TM, Rubin CT 1990 Cement line staining in undecalcified thin sections of cortical bone. Stain Technol 65:159163.
  • 23
    Zhao G, Monier-Faugere MC, Langub MC, Geng Z, Nakayama T, Pike JW, Chernausek SD, Rosen CJ, Donahue LR, Malluche HH, Fagin JA, Clemens TL 2000 Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: Increased trabecular bone volume without increased osteoblast proliferation. Endocrinology 141:26742682.
  • 24
    Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR 1987 Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595610.
  • 25
    Pedersen EA, Akhter MP, Cullen DM, Kimmel DB, Recker RR 1999 Bone response to in vivo mechanical loading in C3H/HeJ mice. Calcif Tissue Int 65:4146.
  • 26
    Sheng MH, Baylink DJ, Beamer WG, Donahue LR, Rosen CJ, Lau KH, Wergedal JE 1999 Histomorphometric studies show that bone formation and bone mineral apposition rates are greater in C3H/HeJ (high-density) than C57BL/6J (low-density) mice during growth. Bone 25:421429.
  • 27
    Rubin CT, Lanyon LE 1984 Regulation of bone formation by applied dynamic loads. J Bone Joint Surg Am 66:397402.
  • 28
    Hillam RA, Skerry TM 1995 Inhibition of bone resorption and stimulation of formation by mechanical loading of the modeling rat ulna in vivo. J Bone Miner Res 10:683689.
  • 29
    Rosen CJ, Churchill GA, Donahue LR, Shultz KL, Burgess JK, Powell DR, Beamer WG 2000 Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice. Bone 27:521528.
  • 30
    Lean JM, Jagger CJ, Chambers TJ, Chow JW 1995 Increased insulin-like growth factor I mRNA expression in rat osteocytes in response to mechanical stimulation. Am J Physiol 268:E318E327.
  • 31
    Snow CM, Rosen CJ, Robinson TL 2000 Serum IGF-I is higher in gymnasts than runners and predicts bone and lean mass Med Sci Sports Exerc 32:19021907.
  • 32
    Chow JW, Fox S, Jagger CJ, Chambers TJ 1998 Role for parathyroid hormone in mechanical responsiveness of rat bone. Am J Physiol 274:E146E154.