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Impaired Vascular Invasion of Cbfa1-Deficient Cartilage Engrafted in the Spleen†
Article first published online: 1 JUL 2002
DOI: 10.1359/jbmr.2002.17.7.1297
Copyright © 2002 ASBMR
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How to Cite
Himeno, M., Enomoto, H., Liu, W., Ishizeki, K., Nomura, S., Kitamura, Y. and Komori, T. (2002), Impaired Vascular Invasion of Cbfa1-Deficient Cartilage Engrafted in the Spleen. J Bone Miner Res, 17: 1297–1305. doi: 10.1359/jbmr.2002.17.7.1297
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Publication History
- Issue published online: 2 DEC 2009
- Article first published online: 1 JUL 2002
- Manuscript Accepted: 6 FEB 2002
- Manuscript Revised: 14 JAN 2002
- Manuscript Received: 19 JUN 2001
REFERENCES
- 1, 1996 The structure and development of bone. In: BilezikianJP, RaiszLG, RodanGA (eds.) Principles of Bone Biology. Academic Press, London, UK, pp. 3–14.
- 2, 1983 Vascularity of cartilage. In: HallBK (ed.) Cartilage, vol 1. Academic Press, New York, NY, USA, pp. 281–312.
- 3, , , , , , , 1997 Transferrin promotes endothelial cell migration and invasion: Implication in cartilage neovascularization. J Cell Biol 136:1375–1384.
- 4, , , , , 1999 VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5:623–628.
- 5, , , , , , , , 1995 Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. Cell Growth Differ 6:759–767.
- 6, , , , , , , , 1997 Identification of chondromodulin I as a novel endothelial cell growth inhibitor. Purification and its localization in the avascular zone of epiphyseal cartilage. J Biol Chem 272:32419–32426.
- 7, 1991 A metalloproteinase inhibitor as an inhibitor of neovascularization. J Cell Biochem 47:230–235.
- 8, , , , , , , , 1998 MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93:411–422.
- 9, , , 1998 Role of the subchondral vascular system in endochondral ossification: Endothelial cells specifically derepress late differentiation in resting chondrocytes in vitro. Exp Cell Res 238:491–497.
- 10, 1998 Cbfa1 in bone development. Curr Opin Genet Dev 8:494–499.
- 11, , , , , , , , , , , , , , 1997 Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755–764.
- 12, , , , , , , , , , , 1997 Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765–771.
- 13, , , , , , , , , 2001 Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J Cell Biol 155:157–166.
- 14, , , , , , , , , , , , , , 1999 Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn 214:279–290.
- 15, , , 1999 Regulation of chondrocyte differentiation by cbfa1. Mech Dev 80:159–170.
- 16, , 1999 Morphological characterization of skeletal cells in Cbfa1-deficient mice. Bone 25:639–651.
- 17, , , , , , , 2000 Cbfa1 is a positive regulatory factor in chondrocyte maturation. J Biol Chem 275:8695–8702.
- 18, , , , , , , , , , , 2001 Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol 153:87–100.
- 19, , , , 2001 Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev 15:467–481.
- 20, , , 1992 Morphological modifications during long-term survival of Meckel's cartilage hypertrophic chondrocytes transplanted in the mouse spleen. Arch Histol Cytol 55:261–272.
- 21, , , , , , , 1997 Lack of vacuolar proton ATPase association with the cytoskeleton in osteoclasts of osteosclerotic (oc/oc) mice. FEBS Lett 401:207–212.
- 22, , , 1991 Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs. Biochim Biophys Acta 1089:241–243.
- 23, , , , , , 1995 Modulated expression of type X collagen in the Meckel's cartilage with different developmental fates. Dev Biol 170:387–396.
- 24, , , , 1988 Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. J Cell Biol 106:441–450.
- 25, , , , , 1999 Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol Cell Biol 19:4431–4442.
- 26, , , , , , , , , 1994 Expression of mRNA of murine bone-related proteins in ectopic bone induced by murine bone morphogenetic protein-4. Cell Tissue Res 277:27–32.
- 27, , 1990 Preparation of DNA and RNA. In: Methods for Cloning and Analysis of Eukaryotic Genes. Jones and Bartlett Publishers, Boston, MA, USA, pp. 15–16.
- 28, , 1975 Osteogenesis by chondrocytes from growth cartilage of rat rib. Calcif Tissue Res 19:179–187.
- 29, , , , , , , , , , 2001 Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis. Mech Dev 109:413–417.
- 30, , , 1993 Molecular and cellular biology of the major noncollagenous proteins in bone. In: NodaM (ed.) Cellular and Molecular Biology of Bone. Academic Press, London, UK, pp. 191–234.
- 31, , , , 1996 Biochemical characterization of human collagenase-3. J Biol Chem 271:1544–1550.
- 32, , , , , , , , , , , , , 1998 Transcriptional regulation of osteopontin gene in vivo by PEBP2αA/CBFA1 and ETS1 in the skeletal tissues. Oncogene 17:1517–1525.
- 33, , , 2000 Developmental regulation of collagenase-3 mRNA in normal, differentiating osteoblasts through the activator protein-1 and the runt domain binding sites. J Biol Chem 275:23310–23318.
- 34, , , , , , , , 1999 Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone. Oncogene 18:667–678.
- 35, , , 2000 Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor α1. J Biol Chem 275:5037–5042.
- 36, 1996 Signal transduction pathways mediating parathyroid hormone stimulation of bone sialoprotein gene expression in osteoblasts. J Biol Chem 271:29839–29846.
- 37, , , , , , 1997 Transforming growth factor-β1 regulation of bone sialoprotein gene transcription: Identification of a TGF-β activation element in the rat BSP gene promoter. J Cell Biochem 65:501–512.

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