• 1
    Kember NF 1960 Cell divisions in endochondral ossification. A study of cell proliferation in rat bones by the method of tritiated thymidine autoradiography. J Bone Joint Surg Br 42:824839.
  • 2
    Ohlsson C, Isgaard J, Tornell J, Nilsson A, Isaksson OGP, Lindahl A 1993 Review paper: Endocrine regulation of longitudinal bone growth. Acta Paed Suppl 391:3340.
  • 3
    Isaksson OGP 1982 Growth hormone stimulates longitudinal bone growth directly. Science 216:12371239.
  • 4
    Spencer G, Hodgkinson SC, Bass JJ 1991 Passive immunization against insulin-like growth factor-I does not inhibit growth hormone-stimulated growth of dwarf rats. Endocrinology 128:21032109.
  • 5
    Sjogren K, Liu JL, Blad K, Skrtic S, Vidal O, Wallenius V, LeRoith D, Tornell J, Isaksson OG, Jansson JO, Ohlsson C 1999 Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. Proc Natl Acad Sci USA 96:70887092.
  • 6
    Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, LeRoith D 1999 Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci USA 96:73247329.
  • 7
    Ohlsson C, Nilsson A, Isaksson O, Lindahl A 1992 Growth hormone induces multiplication of the slowly cycling germinal cells of the rat tibial growth plate. Proc Natl Acad Sci USA 89:98269830.
  • 8
    Nilsson A, Isgaard J, Lindahl A, Dahlstrom A, Skottner A, Isaksson OGP 1986 Regulation by growth hormone of number of chondrocytes containing IGF-I in rat growth plate. Science 233:571574.
  • 9
    Isaksson OGP, Lindahl A, Nilsson A, Isgaard J 1987 Review paper: Mechanism of the stimulatory effect of growth hormone on longitudinal bone growth. Endocr Rev 8:426438.
  • 10
    Barnard R, Haynes KM, Werther GA, Waters MJ 1988 The ontogeny of growth hormone-receptors in the rabbit tibia. Endocrinology 122:25622569.
  • 11
    Barnard R, Bundesen PG, Rylatt DB, Waters MJ 1984 Monoclonal antibodies to the rabbit liver growth hormone receptor; production and characterization. Endocrinology 115:18051813.
  • 12
    Leung DW, Spencer SA, Cachianes G, Hammonds RG, Collins C, Henzel WJ, Barnard R, Waters MJ, Wood WI 1987 Growth hormone receptor and serum binding protein: Purification, cloning and expression. Nature 330:537543.
  • 13
    Carlsson B, Billig H, Rymo L, Isaksson O 1990 Expression of the growth hormone-binding protein messenger-RNA in the liver and extrahepatic tissues in the rat—coexpression with the growth-hormone receptor. Mol Cell Endocrinol 73:R1R6.
  • 14
    Fairhall KM, Carmignac DF, Robinson ICAF 1992 Growth hormone (GH) binding protein and GH interaction in vivo in the guinea pig. Endocrinology 131:19631969.
  • 15
    Lim L, Spencer SA, McKay P, Waters MJ 1990 Regulation of growth hormone (GH) bioactivity by a recombinant human GH-binding protein. Endocrinology 127:12871291.
  • 16
    Dattani MT, Hindmarsh PC, Brook CG, Robinson IC, Marshall NJ 1994 Inhibition of growth hormone bioactivity by recombinant human growth hormone-binding protein in the eluted stain assay system. J Endocrinol 140:445453.
  • 17
    Baumbach WR, Horner DL, Logan JS 1989 The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor. Genes Dev 3:11991205.
  • 18
    Tiong TS, Herington AC 1991 Tissue distribution, characterization, and regulation of messenger-ribonucleic-acid for growth hormone receptor and serum binding-protein in the rat. Endocrinology 129:16281634.
  • 19
    Walker JL, Moatsstaats BM, Stiles AD, Underwood LE 1992 Tissue-specific developmental regulation of the messenger ribonucleic-acids encoding the growth hormone receptor and the growth-hormone binding-protein in rat fetal and postnatal tissues. Pediaetr Res 31:335339.
  • 20
    Baumbach WR, Bingham B 1995 One class of growth hormone (GH) receptor and binding protein messenger ribonucleic acid in rat liver, GHR1, is sexually dimorphic and regulated by GH. Endocrinology 136:749760.
  • 21
    Domene HM, Cassorla F, Werner H, Roberts CJ, Leroith D 1995 Rat growth hormone receptor/growth hormone-binding protein mRNAs with divergent 5′-untranslated regions are expressed in a tissue-specific manner. DNA Cell Biol 14:195204.
  • 22
    Sadeghi H, Wang BS, Lumanglas AL, Logan JS, Baumbach WR 1990 Identification of the origin of the growth hormone-binding protein in rat serum. Mol Endocrinol 4:17991805.
  • 23
    Charlton HM, Clark RG, Robinson ICAF, Porter-Goff AE, Cox BS, Bugnon C, Bloch BS 1988 Growth hormone-deficient dwarfism in the rat: A new mutation. J Endocrinol 119:5158.
  • 24
    Chomczynski P, Sacchi N 1987 Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156159.
  • 25
    Barnard R, Thordarson G, Lopez MF, Yamaguchi M, Edens A, Cramer SD, Ogren L, Talamantes F 1994 Expression of growth hormone-binding protein with a hydrophilic carboxyl terminus by the mouse placenta: Studies in vivo and in vitro. J Endocrinol 140:125135.
  • 26
    Madsen K, Friberg U, Roos P, Edén S, Isaksson OGP 1983 Growth hormone stimulates the proliferation of cultured chondrocytes from rabbit ear and rat rib growth cartilage. Nature 304:545547.
  • 27
    Raap AK, van de Corput MP, Vervenne RA, van Gijlswijk RP, Tanke HJ, Wiegant J 1995 Ultra-sensitive FISH using peroxidase-mediated deposition of biotin- or fluorochrome tyramides. Hum Mol Genet 4:529534.
  • 28
    van der Eerden BC, Karperien M, Gevers EF, Lowik CW, Wit JM 2000 Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the postnatal growth plate of the rat: Evidence for a locally acting growth restraining feedback loop after birth. J Bone Miner Res 15:10451055.
  • 29
    Ross RJ 1999 Truncated growth hormone receptor isoforms. Acta Paediatr Suppl 88:164166.
  • 30
    Garcia Aragon J, Lobie PE, Muscat G, Gobius KS, Norstedt G, Waters MJ 1992 Prenatal expression of the growth hormone (GH) receptor/binding protein in the rat: A role for GH in embryonic and fetal development? Development 114:869876.
  • 31
    Vidal NO, Ekberg S, Enerback S, Lindahl A, Ohlsson C 1997 The CCAAT/enhancer-binding protein-alpha is expressed in the germinal layer of the growth plate: Colocalisation with the growth hormone receptor. J Endocrinol 155:433441.
  • 32
    Langenskiold A, Videman T, Nevalainen T 1993 Vital staining indicating cell migration towards the periphery in the growth plate. Studies of fibular heads in rabbits. Acta Orthop Scand 64:683687.
  • 33
    Lupu F, Terwilliger JD, Lee K, Segre GV, Efstratiadis A 2001 Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol 229:141162.
  • 34
    Lin FT, Lane MD 1994 CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc Natl Acad Sci USA 91:87578761.
  • 35
    Hunziker EB, Wagner J, Zapf J 1994 Differential effects of insulin-like growth factor I and growth hormone on developmental stages of rat growth plate chondrocytes in vivo. J Clin Invest 93:10781086.
  • 36
    Reinecke M, Schmid AC, Heyberger-Meyer B, Hunziker EB, Zapf J 2000 Effect of growth hormone and insulin-like growth factor I (IGF-I) on the expression of IGF-I messenger ribonucleic acid and peptide in rat tibial growth plate and articular chondrocytes in vivo. Endocrinology 141:28472853.
  • 37
    Edmondson SR, Baker NL, Oh J, Kovacs G, Werther GA, Mehls O 2000 Growth hormone receptor abundance in tibial growth plates of uremic rats: GH/IGF-I treatment. Kidney Int 58:6270.
  • 38
    Lindahl A, Nilsson A, Isaksson OGP 1987 Effects of growth hormone and insulin-like growth factor-I on colony formation of rabbit epiphyseal chondrocytes at different stages of maturation. J Endocrinol 115:263271.
  • 39
    Lindahl A, Isgaard J, Carlsson L, Isaksson OGP 1987 Differential effects of growth hormone and insulin-like growth factor I on colony formation of epiphyseal chondrocytes in suspension culture in rats of different ages. Endocrinology 121:10611069.
  • 40
    Gevers EF, Milne J, Robinson ICAF, Loveridge N 1996 Single cell enzyme activity and proliferation in the growth plate: Effects of growth hormone. J Bone Miner Res 11:11031111.
  • 41
    Edmondson SR, Werther GA, Russell A, LeRoith D, Roberts CT Jr, Beck F 1995 Localization of growth hormone receptor/binding protein messenger ribonucleic acid (mRNA) during rat fetal development: Relationship to insulin-like growth factor-I mRNA. Endocrinology 136:46024609.
  • 42
    Lobie PE, Wood TJ, Chen CM, Waters MJ, Norstedt G 1994 Nuclear translocation and anchorage of the growth hormone receptor. J Biol Chem 269:3173531746.
  • 43
    Lobie PE, Garcia-Aragon J, Wang BS, Baumbach WR, Waters JM 1992 Cellular localization of the GH-binding protein in the rat. Endocrinology 130:30573065.
  • 44
    Lobie PE, Mertani H, Morel G, Morales-Bustos O, Norstedt G, Waters MJ 1994 Receptor-mediated nuclear translocation of growth hormone. J Biol Chem 269:2133021339.
  • 45
    Maes M, de Hertogh R, Watrin-Granger P, Ketelslegers JM 1983 Ontogeny of liver somatotropic and lactogenic binding sites in male and female rats. Endocrinology 113:13251332.
  • 46
    Massa G, Mulumba N, Ketelslegers J-M, Maes M 1990 Initial characterization and sexual dimorphism of serum growth hormone-releasing binding protein in adult rats. Endocrinology 126:19761980.
  • 47
    Carmignac DF, Wells T, Carlsson LMS, Clark RG, Robinson ICAF 1992 Growth hormone (GH)-binding protein in normal and GH-deficient dwarf rats. J Endocrinol 135:447457.
  • 48
    Robinson I, Carmignac DF, Fairhall KM 1993 Growth hormone (GH) receptors, GH binding protein and GH: An autoregulatory system? Int J Paed Suppl 82:2228.
  • 49
    Lewinson D, Bialik G, Hochberg Z 1994 Differential effects of hypothyroidism on the cartilage and the osteogenic process in the mandibular condyle: Recovery by growth hormone and thyroxine. Endocrinology 135:15041510.
  • 50
    Jingushi S, Scully SP, Joyce ME, Sugioka Y, Bolander ME 1995 Transforming growth factor-beta1 and fibroblast growth factors in rat growth plate. J Orthop Res 13:761768.
  • 51
    Vortkamp A, Lee K, Lanske B, Segre V, Kronenberg HM, Tabin C 1996 Regulation of rate of cartilage differentiation by Indian Hedgehog and PTH-related protein. Science 273:613621.
  • 52
    Lanske B, Karaplis AC, Lee K, Luz A, Vortkamp A, Pirro A, Karperien M, Defize LHK, Ho C, Mulligan RC, Abou-Samra A-B, Juppner H, Segre GV, Kronenberg HM 1996 PTH/PTHrP receptor in early development and indian hedgehog-regulated bone growth. Science 273:663666.
  • 53
    Kato Y, Iwamoto M 1990 Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation. J Biol Chem 265:59035909.
  • 54
    Wroblewski J, Edwall AC 1995 Inhibitory effects of basic fibroblast growth factor on chondrocyte differentiation. J Bone Miner Res 10:735742.
  • 55
    Gabrielsson BG, Carmignac DF, Flavell DM, Robinson ICAF 1995 Steroid regulation of growth hormone (GH) receptor and GH binding protein messenger ribonucleic acids in the rat. Endocrinology 136:209217.
  • 56
    King AP, Carter SC 1995 Dexamethasone-induced antagonism of growth hormone (GH) action by down-regulation of GH binding in 3T3-F442A fibroblasts. Endocrinology 136:4796803.
  • 57
    Heinrichs C, Yanovski JA, Roth AH, Yu YM, Domene HM, Yano K, Cutler GB Jr, Baron J 1994 Dexamethasone increases growth hormone receptor messenger ribonucleic acid levels in liver and growth plate. Endocrinology 135:11131118.
  • 58
    Jux C, Leiber K, Hugel U, Blum W, Ohlsson C, Klaus G, Mehls O 1998 Dexamethasone impairs growth hormone (GH)-stimulated growth by suppression of local insulin-like growth factor (IGF)-I production and expression of GH- and IGF-I-receptor in cultured rat chondrocytes. Endocrinology 139:32963305.
  • 59
    Abu EO, Horner A, Kusec V, Triffitt JT, Compston JE 2000 The localization of the functional glucocorticoid receptor alpha in human bone. J Clin Endocrinol Metab 85:883889.
  • 60
    Kopchick JJ, Bellush LL, Coschigano KT 1999 Transgenic models of growth hormone action. Annu Rev Nutr 19:437461.
  • 61
    Mathews LS, Hammer RE, Behringer RR, Dercole AJ, Bell GI, Brinster RL, Palmiter RD 1988 Growth enhancement of transgenic mice expressing human insulin-like growth factor I. Endocrinology 123:28272833.
  • 62
    Behringer RR, Lewin TM, Quaife CJ, Palmiter RD, Brinster RL, D'Ercole AJ 1990 Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic mice. Endocrinology 127:10331040.
  • 63
    Sims NA, Clement-Lacroix P, Da Ponte F, Bouali Y, Binart N, Moriggl R, Goffin V, Coschigano K, Gaillard-Kelly M, Kopchick J, Baron R, Kelly PA 2000 Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5. J Clin Invest 106:10951103.
  • 64
    Backeljauw PF, Underwood LE 2001 Therapy for 6.5–7.5 years with recombinant insulin-like growth factor I in children with growth hormone insensitivity syndrome: A clinical research center study. J Clin Endocrinol Metab 86:15041510.