• 1
    Nusse RU 1999 WNT targets: Repression and activation. Trends Genet 15:13.
  • 2
    Moon RT, Brown JD, Torres M, Brown JDU 1997 WNTs modulate cell fate and behavior during vertebrate development. Trends Genet 13:157162.
  • 3
    Bejsovec AU 2000 Wnt signaling: An embarrassment of receptors. Curr Biol 10:R919R922.
  • 4
    Miller JR, Hocking AM, Brown JD, Moon RT 1999 Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways. Oncogene 18:78607872.
  • 5
    Polakis P 2000 Wnt signaling and cancer. Genes Dev 14:18371851.
  • 6
    Anderton BHU 1999 Alzheimer's disease: Clues from flies and worms. Curr Biol 9:R106R109.
  • 7
    Levasseur R, Kato M, Patel MS, Chan L, Karsenty G 2001 Low bone mass, low body weight and abnormal eye vascularization in mice deficient in LRP5, the gene mutated in human osteoporosis pseudoglioma syndrome. J Bone Miner Res 16:S152.
  • 8
    Kato M, Patel MS, Levasseur R, Lobov I, Chang BH, Glass DA II, Hartmann C, Li L, Hwang TH, Brayton CF, Lang RA, Karsenty G, Chan L 2002 Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol 157:303314.
  • 9
    Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GC, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Juppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard MJ, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML 2001 LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107:513523.
  • 10
    Little RD, Carulli JP, Del Mastro RG, Dupuis J, Osborne M, Folz C, Manning SP, Swain PM, Zhao S, Eustace B, Lappe MM, Spitzer L, Zweier S, Braunschweiger K, Benchekroun Y, Hu X, Adair R, Chee L, FitzGerald MG, Tulig C, Caruso A, Tzellas N, Bawa A, Franklin B, McGuire S, Nogues X, Gong G, Allen KM, Anisowicz A, Morales AJ, Lomedico PT, Recker SM, Eerdewegh PV, Recker RR, Johnson ML 2002 A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet 70:1119.
  • 11
    Boyden LM, Mao J, Belsky J, Mitzner L, Farhi A, Mitnick MA, Wu D, Insogna K, Lifton RP 2002 High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 346:15131521.
  • 12
    Ducy P 2000 CBFA1: A molecular switch in osteoblast biology. Dev Dyn 219:46171.
  • 13
    Karsenty G 2001 Minireview: Transcriptional control of osteoblast differentiation. Endocrinology 142:27312733.
  • 14
    Sheikh SS, Mbalaviele G, Warlow P, Civitelli R 2001 Beta-catenin signaling during osteoblast differentiation. J Bone Miner Res 16:S368.
  • 15
    Gallea S, Lallemand F, Atfi A, Rawadi G, Ramez V, Spinella-Jaegle S, Kawai S, Faucheu C, Huet L, Baron R, Roman-Roman S 2001 Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells. Bone 28:491498.
  • 16
    Spinella-Jaegle S, Rawadi G, Kawai S, Gallea S, Faucheu C, Mollat P, Courtois B, Bergaud B, Ramez V, Blanchet AM, Adelmant G, Baron R, Roman-Roman S 2001 Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation. J Cell Sci 114:20852094.
  • 17
    Sokol S 1996 Analysis of dishevelled signalling pathways during Xenopus development. Curr Biol 6:14561467.
  • 18
    Yanagawa S, van Leeuwen F, Wodarz A, Klingensmith J, Nusse R 1995 The dishevelled protein is modified by wingless signaling in Drosophila. Genes Dev 9:10871097.
  • 19
    Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW 1997 Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275:17871790.
  • 20
    Leung TW, Lin SS, Tsang AC, Tong CS, Ching JC, Leung WY, Gimlich R, Wong GG, Yao KM 2001 Over-expression of FoxM1 stimulates cyclin B1 expression. FEBS Lett 507:5966.
  • 21
    Wang EA, Israel DI, Kelly S, Luxenberg DP 1993 Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. Growth Factors 9:5771.
  • 22
    Stanford CM, Jacobson PA, Eanes ED, Lembke LA, Midura RJ 1995 Rapidly forming apatitic mineral in an osteoblastic cell line (UMR 106–01 BSP). J Biol Chem 270:94209428.
  • 23
    Shimizu H, Julius MA, Giarre M, Zheng Z, Brown AM, Kitajewski J 1997 Transformation by Wnt family proteins correlates with regulation of beta-catenin. Cell Growth Differ 8:13491358.
  • 24
    Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B, Clevers H 1997 Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma. Science 275:17841787.
  • 25
    Hedgepeth CM, Conrad LJ, Zhang J, Huang HC, Lee VM, Klein PS 1997 Activation of the Wnt signaling pathway: A molecular mechanism for lithium action. Dev Biol 185:8291.
  • 26
    Klein PS, Melton DA 1996 A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA 93:84558459.
  • 27
    Zorn AM 2001 Wnt signalling: Antagonistic Dickkopfs. Curr Biol 11:R592R595.
  • 28
    Nusse R 2001 Developmental biology. Making head or tail of Dickkopf. Nature 411:255256.
  • 29
    Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C 1998 Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391:357362.
  • 30
    Bafico A, Liu G, Yaniv A, Gazit A, Aaronson SA 2001 Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol 3:683686.
  • 31
    Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, He X 2001 Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol 11:951961.
  • 32
    Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C 2001 LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411:321325.
  • 33
    Scaal M, Prols F, Fuchtbauer EM, Patel K, Hornik C, Kohler T, Christ B, Brand-Saberi B 2002 BMPs induce dermal markers and ectopic feather tracts. Mech Dev 110:5160.
  • 34
    Mullor JL, Dahmane N, Sun T, Ruiz i Altaba A 2001 Wnt signals are targets and mediators of Gli function. Curr Biol 11:769773.
  • 35
    Borycki A, Brown AM, Emerson CP 2000 Shh and Wnt signaling pathways converge to control Gli gene activation in avian somites. Development 127:20752087.
  • 36
    Zimmerman LB, De Jesus-Escobar JM, Harland RM 1996 The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86:599606.
  • 37
    Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA 2000 Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine. Nature 406:10051009.
  • 38
    Miyazono K 1999 Signal transduction by bone morphogenetic protein receptors: Functional roles of Smad proteins. Bone 25:9193.
  • 39
    Ingham PW, McMahon AP 2001 Hedgehog signaling in animal development: Paradigms and principles. Genes Dev 15:30593087.
  • 40
    Spinella-Jaegle S, Roman-Roman S, Faucheu C, Dunn FW, Kawai S, Gallea S, Stiot V, Blanchet AM, Courtois B, Baron R, Rawadi G 2001 Opposite effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on osteoblast differentiation. Bone 29:323330.
  • 41
    Fischer L, Boland G, Tuan RS 2002 Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesis. J Cell Biochem 84:816831.
  • 42
    Reddy S, Andl T, Bagasra A, Lu MM, Epstein DJ, Morrisey EE, Millar SE 2001 Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev 107:6982.
  • 43
    Mullor JL, Dahmane N, Sun T, Ruiz i Altaba A 2001 Wnt signals are targets and mediators of Gli function. Curr Biol 11:769773.
  • 44
    Willert J, Epping M, Pollack J, Brown P, Nusse R 2002 A transcriptional response to Wnt protein in human embryonic carcinoma cells. Biomed Central Dev Biol 2:18.
  • 45
    Ross SE, Erickson RL, Gerin I, DeRose PM, Bajnok L, Longo KA, Misek DE, Kuick R, Hanash SM, Atkins KB, Andresen SM, Nebb HI, Madsen L, Kristiansen K, MacDougald OA 2002 Microarray analyses during adipogenesis: Understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism. Mol Cell Biol 22:59895999.
  • 46
    Bex F, Babij P, Zhao W, Kharode Y, Small C, Reddy P, Yaworsky P, Bodine P, Bhat B, Robinson J, Bouxsein M, Moran R 2002 Skeletal phenotype of mice expressing the human high bone mass gene. J Bone Miner Res 17:S1.;S188
  • 47
    Harada H, Tagashira S, Fujiwara M, Ogawa S, Katsumata T, Yamaguchi A, Komori T, Nakatsuka M 1999 Cbfa1 isoforms exert functional differences in osteoblast differentiation. J Biol Chem 274:69726978.
  • 48
    Lee KS, Kim HJ, Li QL, Chi XZ, Ueta C, Komori T, Wozney JM, Kim EG, Choi JY, Ryoo HM, Bae SC 2000 Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 20:87838792.
  • 49
    Zhang YW, Yasui N, Ito K, Huang G, Fujii M, Hanai J, Nogami H, Ochi T, Miyazono K, Ito Y 2000 A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci USA 97:1054910554.
  • 50
    Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL, MacDougald OA 2000 Inhibition of adipogenesis by Wnt signaling. Science 289:950953.
  • 51
    Beresford JN, Bennett JH, Devlin C, Leboy PS, Owen ME 1992 Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci 102:341351.
  • 52
    Burkhardt R, Kettner G, Bohm W, Schmidmeier M, Schlag R, Frisch B, Mallmann B, Eisenmenger W, Gilg T 1987 Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: A comparative histomorphometric study. Bone 8:157164.
  • 53
    D'Ippolito G, Schiller PC, Ricordi C, Roos BA, Howard GA 1999 Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow. J Bone Miner Res 14:11151122.
  • 54
    Nuttall ME, Patton AJ, Olivera DL, Nadeau DP, Gowen M 1998 Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: Implications for osteopenic disorders. J Bone Miner Res 13:371382.
  • 55
    Kveiborg M, Sabatakos G, Chiusaroli R, Wu M, Grant W, Horne WC, Philbrick WM, Baron R 2002 Bone specific DeltaFosB induced osteosclerosis is independent of adipogenesis. J Bone Miner Res 17:S1;S149.