The authors have no conflict of interest.
Research Article
You have full text access to this OnlineOpen article
A Common Methylenetetrahydrofolate Reductase (C677T) Polymorphism Is Associated With Low Bone Mineral Density and Increased Fracture Incidence After Menopause: Longitudinal Data From the Danish Osteoporosis Prevention Study†
Article first published online: 1 APR 2003
DOI: 10.1359/jbmr.2003.18.4.723
Copyright © 2003 ASBMR
Additional Information
How to Cite
Abrahamsen, B., Madsen, J. S., Landbo Tofteng, C., Stilgren, L., Bladbjerg, E. M., Kristensen, S. R., Brixen, K. and Mosekilde, L. (2003), A Common Methylenetetrahydrofolate Reductase (C677T) Polymorphism Is Associated With Low Bone Mineral Density and Increased Fracture Incidence After Menopause: Longitudinal Data From the Danish Osteoporosis Prevention Study. J Bone Miner Res, 18: 723–729. doi: 10.1359/jbmr.2003.18.4.723
- †
Publication History
- Issue published online: 2 DEC 2009
- Article first published online: 1 APR 2003
- Manuscript Accepted: 15 OCT 2002
- Manuscript Revised: 23 AUG 2002
- Manuscript Received: 8 NOV 2001
REFERENCES
- 1, , , , , 1993 Changes in axial bone density with age: A twin study. J Bone Miner Res 8:11–17.
- 2, , , , , 1994 Osteoporosis and genetic influence: A three generation study. Postgrad Med J 70:798–800.
- 3, , , , , , , , 2000 Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women. Calcif Tissue Int 66:190–194.
- 4, , , , 1996 Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria. Biochim Biophys Acta 1315:159–162.
- 5, , , , , , 2002 Effect of long-term hormone replacement therapy on plasma homocysteine in postmenopausal women: A randomized controlled study. Am J Obstet Gynecol 187:33–39.
- 6, , , , , 1999 The Danish Osteoporosis Prevention Study (DOPS): Project design and inclusion of 2000 normal perimenopausal women. Maturitas 31:207–219.
- 7, , , , , 1997 Improving compliance with hormonal replacement therapy in primary osteoporosis prevention. Maturitas 28:137–145.
- 8, , , , 1997 Site of osteodensitometry in perimenopausal women: Correlation and limits of agreement between anatomic regions. J Bone Miner Res 12:1471–1479.
- 9, , , , , , , , , , , , , , , , , 2000 Hormonal replacement therapy reduces forearm fracture incidence in recent postmenopausal women-results of the Danish Osteoporosis Prevention Study. Maturitas 36:181–193.
- 10, , , , , 1997 Genetic polymorphism of 5, 10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease. Circulation 95:2032–2036.
- 11, , , , , 1996 Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. Nat Genet 14:203–205.
- 12, , , , , , , , , 1998 Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N Engl J Med 338:1016–1021.
- 13, , , 1998 An Sp1 binding site polymorphism in the COL1A1 gene predicts osteoporotic fractures in both men and women. J Bone Miner Res 13:1384–1389.
- 141977 Skeletal abnormalities in homocystinuria. Postgrad Med J 53:488–496.
- 151998 The metabolism of homocysteine: Pathways and regulation. Eur J Paediatr Nuerol 157:S40–S44.
- 16, , , , , , 1994 Human methylenetetrahydrofolate reductase: Isolation of cDNA, mapping and mutation identification. Nat Genet 7:195–200.
- 17, , , , , , , 1998 Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm Genome 9:652–656.
- 18, , , 1996 Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR. Am J Hum Genet 59:1268–1275.
- 19, , , , , , 2002 Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case control study in Danish postmenopausal women. Calcif Tissue Int 71:386–392.

1523-4681/asset/olbannerleft.gif?v=1&s=d7e4c0e37904a489128d3a4e58ba94214db307a9)
1523-4681/asset/olbannerright.gif?v=1&s=854ee0e4d351ead9faaca8bfab3e50b1c7c9d03d)
1523-4681/asset/cover.gif?v=1&s=a8419ff5f302b0d9fefec557d81c0aa9776c60e3)