SEARCH

SEARCH BY CITATION

REFERENCES

  • 1
    Canalis E, Delany AM 2002 Mechanisms of glucocorticoid action in bone. Ann NY Acad Sci 966:7381.
  • 2
    Kream B, Lukert B 2002 Clinical and basic aspects of glucocorticoid action in bone. In: BilezikianJP, RaiszLG, RodanGA (eds.) Principles of Bone Biology, 2nd ed. Academic Press, San Diego, CA, USA, pp. 723740.
  • 3
    Chen TL, Cone CM, Feldman D 1983 Glucocorticoid modulation of cell proliferation in cultured osteoblast-like bone cells: Differences between rat and mouse. Endocrinology 112:17391745.
  • 4
    Chevalley T, Strong DD, Mohan S, Baylink D, Linkhart TA 1996 Evidence for a role for insulin-like growth factor binding proteins in glucocorticoid inhibition of normal human osteoblast-like cell proliferation. Eur J Endocrinol 134:591601.
  • 5
    Smith E, Redman RA, Logg CR, Coetzee GA, Kasahara N, Frenkel B 2000 Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes. J Biol Chem 275:1999220001.
  • 6
    Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC 1998 Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest 102:274282.
  • 7
    Delany AM, Gabbitas BY, Canalis E 1995 Cortisol downregulates osteoblast alpha 1 (I) procollagen mRNA by transcriptional and posttranscriptional mechanisms. J Cell Biochem 57:488494.
  • 8
    Chang DJ, Ji C, Kim KK, Casinghino S, McCarthy TL, Centrella M 1998 Reduction in transforming growth factor beta receptor I expression and transcription factor CBFa1 on bone cells by glucocorticoid. J Biol Chem 273:48924896.
  • 9
    Urist MR 1965 Bone: Formation by autoinduction. Science 150:893899.
  • 10
    Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA 1988 Novel regulators of bone formation: Molecular clones and activities. Science 242:15281534.
  • 11
    Wang EA, Rosen V, Cordes P, Hewick RM, Kriz MJ, Luxenberg DP, Sibley BS, Wozney JM 1988 Purification and characterization of other distinct bone-inducing factors. Proc Natl Acad Sci USA 85:94849488.
  • 12
    Yamaguchi A, Katagiri T, Ikeda T, Wozney JM, Rosen V, Wang EA, Kahn AJ, Suda T, Yoshiki S 1991 Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J Cell Biol 113:681687.
  • 13
    Sampath TK, Maliakal JC, Hauschka PV, Jones WK, Sasak H, Tucker RF, White KH, Coughlin JE, Tucker MM, Pang RH, Corbett C, Özkaynak E, Opperman H, Rueger DC 1992 Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. J Biol Chem 267:2035220362.
  • 14
    Gitelman SE, Kobrin MS, Ye JQ, Lopez AR, Lee A, Derynck R 1994 Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo. J Cell Biol 126:15951609.
  • 15
    Katagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, Rosen V, Wozney JM, Fujisawa-Sehara A, Suda T 1994 Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol 127:17551766.
  • 16
    Yamaguchi A, Komori T, Suda T 2000 Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr Rev 21:393411.
  • 17
    Takuwa Y, Ohse C, Wang EA, Wozney JM, Yamashita K 1991 Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells MC3T3-E1. Biochem Biophys Res Commun 174:96101.
  • 18
    Yamaguchi A, Ishizuya T, Kintou N, Wada Y, Katagiri T, Wozney JM, Rosen V, Yoshiki S 1996 Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6. Biochem Biophys Res Commun 220:366371.
  • 19
    Boden SD, McCuaig K, Hair G, Racine M, Titus L, Wozney JM, Nanes MS 1996 Differential effects and glucocorticoid potentiation of bone morphogenetic protein action during rat osteoblast differentiation in vitro. Endocrinology 137:34013407.
  • 20
    Gori F, Thomas T, Hicok KC, Spelsberg TC, Riggs BL 1999 Differentiation of human marrow stromal precursor cells: Bone morphogenetic protein-2 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturation. J Bone Miner Res 14:15221535.
  • 21
    Groeneveld EH, Burger EH 2000 Bone morphogenetic proteins in human bone regeneration. Eur J Endocrinol 142:921.
  • 22
    Boden SD, Zdeblick TA, Sandhu HS, Heim SE 2000 The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: A preliminary report. Spine 25:376381.
  • 23
    Valentin-Opran A, Wozney J, Csimma C, Lilly L, Riedel GE 2002 Clinical evaluation of recombinant human bone morphogenetic protein-2. Clin Orthop (395):110120.
  • 24
    Luppen CA, Blake CA, Ammirati KA, Stevens ML, Seeherman HJ, Wozney JM, Bouxsin ML 2002 Recombinant human bone morphogenetic protein-2 enhances osteotomy healing in glucocorticoid treated rabbits. J Bone Miner Res 17:301310.
  • 25
    Centrella M, Rosen V, Wozney JM, Casinghino SR, McCarthy TL 1997 Opposing effects by glucocorticoid and bone morphogenetic protein-2 in fetal rat bone cell cultures. J Cell Biochem 67:528540.
  • 26
    Tullberg-Reinert H, Jundt G 1999 In situ measurement of collagen synthesis by human bone cells with a sirius red-based colorimetric microassay: Effects of transforming growth factor beta2 and ascorbic acid 2-phosphate. Histochem Cell Biol 112:271276.
  • 27
    Held PG 2001 Fluorometric quantitation of hydrolyzed DNA. Lab division applications detail. Available online at http://www.biotek.com. Accessed on January 25, 2002.
  • 28
    Desbois C, Hogue DA, Karsenty G 1994 The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. J Biol Chem 269:11831190.
  • 29
    Kato Y, Boskey A, Spevak L, Dallas M, Hori M, Bonewald LF 2001 Establishment of an osteoid preosteocyte-like cell MLO-A5 that spontaneously mineralizes in culture. J Bone Miner Res 16:16221633.
  • 30
    Paschalis EP, Verdelis K, Doty SB, Boskey AL, Mendelsohn R, Yamauchi M 2001 Spectroscopic characterization of collagen cross-links in bone. J Bone Miner Res 16:18211828.
  • 31
    Boskey AL, Spevak L, Paschalis E, Doty SB, McKee MD 2002 Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone. Calcif Tissue Int 71:145154.
  • 32
    Miller LM, Vairavamurthy V, Chance MR, Mendelsohn R, Paschalis EP, Betts F, Boskey AL 2001 In situ analysis of mineral content and crystallinity in bone using infrared micro-spectroscopy of the nu(4) PO(4)(3-) vibration. Biochim Biophys Acta 1527:1119.
  • 33
    Smith E, Coetzee GA, Frenkel B 2002 Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3beta. J Biol Chem 277:1819118197.
  • 34
    Yoshida Y, Tanaka S, Umemori H, Minowa O, Usui M, Ikematsu N, Hosoda E, Imamura T, Kuno J, Yamashita T, Miyazono K, Noda M, Noda T, Yamamoto T 2000 Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell 103:10851097.
  • 35
    Lecanda F, Avioli LV, Cheng SL 1997 Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2. J Cell Biochem 67:386396.
  • 36
    Yamato K, Hashimoto S, Imamura T, Uchida H, Okahashi N, Koseki T, Ishisaki A, Kizaki M, Miyazono K, Ikeda Y, Nishihara T 2001 Activation of the p21(CIP1/WAF1) promoter by bone morphogenetic protein-2 in mouse B lineage cells. Oncogene 20:43834392.
  • 37
    Huang W, Rudkin GH, Carlsen B, Ishida K, Ghasri P, Anvar B, Yamaguchi DT, Miller TA 2002 Overexpression of BMP-2 modulates morphology, growth, and gene expression in osteoblastic cells. Exp Cell Res 274:226234.
  • 38
    Rickard DJ, Sullivan TA, Shenker BJ, Leboy PS, Kazhdan I 1994 Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev Biol 161:218228.
  • 39
    Lynch MP, Stein JL, Stein GS, Lian JB 1995 The influence of type I collagen on the development and maintenance of the osteoblast phenotype in primary and passaged rat calvarial osteoblasts: Modification of expression of genes supporting cell growth, adhesion, and extracellular matrix mineralization. Exp Cell Res 216:3545.
  • 40
    Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty G 1996 Increased bone formation in osteocalcin-deficient mice. Nature 382:448452.
  • 41
    Stein GS, Lian JB, Stein JL, Van Wijnen AJ, Frenkel B, Montecino M 1996 Mechanisms mediating osteoblast proliferation and differentiation. In: BilezikianJP, RaiszLG, RodanGA (eds.) Principles of Bone Biology. Academic Press, San Diego, CA, USA, pp. 6986.
  • 42
    Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G 1997 Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 89:747754.
  • 43
    Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T 1997 Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755764.
  • 44
    Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GW, Beddington RS, Mundlos S, Olsen BR, Selby PB, Owen MJ 1997 Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765771.
  • 45
    Tsuji K, Ito Y, Noda M 1998 Expression of the PEBP2alphaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells. Bone 22:8792.
  • 46
    Lee KS, Kim HJ, Li QL, Chi XZ, Ueta C, Komori T, Wozney JM, Kim EG, Choi JY, Ryoo HM, Bae SC 2000 Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 20:87838792.
  • 47
    Shen ZJ, Nakamoto T, Tsuji K, Nifuji A, Miyazono K, Komori T, Hirai H, Noda M 2002 Negative regulation of bone morphogenetic protein/Smad signaling by Cas-interacting zinc finger protein in osteoblasts. J Biol Chem 277:2984029846.
  • 48
    Xiao ZS, Thomas R, Hinson TK, Quarles LD 1998 Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor. Gene 214:187197.
  • 49
    Harada H, Tagashira S, Fujiwara M, Ogawa S, Katsumata T, Yamaguchi A, Komori T, Nakatsuka M 1999 Cbfa1 isoforms exert functional differences in osteoblast differentiation. J Biol Chem 274:69726978.
  • 50
    Banerjee C, Javed A, Choi JY, Green J, Rosen V, van Wijnen AJ, Stein JL, Lian JB, Stein GS 2001 Differential regulation of the two principal runx2/cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype. Endocrinology 142:40264039.
  • 51
    Prince M, Banerjee C, Javed A, Green J, Lian JB, Stein GS, Bodine PV, Komm BS 2001 Expression and regulation of Runx2/Cbfa1 and osteoblast phenotypic markers during the growth and differentiation of human osteoblasts. J Cell Biochem 80:424440.
  • 52
    Green JB, New HV, Smith JC 1992 Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 71:731739.
  • 53
    Dosch R, Gawantka V, Delius H, Blumenstock C, Niehrs C 1997 Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus. Development 124:23252334.
  • 54
    Wilson PA, Lagna G, Suzuki A, Hemmati-Brivanlou A 1997 Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. Development 124:31773184.
  • 55
    Xiao G, Gopalakrishnan R, Jiang D, Reith E, Benson MD, Franceschi RT 2002 Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res 17:101110.
  • 56
    Kousteni S, Bellido T, Plotkin LI, O'Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB, Katzenellenbogen JA, Katzenellenbogen BS, Roberson PK, Weinstein RS, Jilka RL, Manolagas SC 2001 Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity. Cell 104:719730.
  • 57
    Lian JB, Shalhoub V, Aslam F, Frenkel B, Green J, Hamrah M, Stein GS, Stein JL 1997 Species-specific glucocorticoid and 1, 25-dihydroxyvitamin D responsiveness in mouse MC3T3-E1 osteoblasts: Dexamethasone inhibits osteoblast differentiation and vitamin D down-regulates osteocalcin gene expression. Endocrinology 138:21172127.
  • 58
    Pereira RM, Delany AM, Canalis E 2001 Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture. Bone 28:484490.
  • 59
    Oreffo RO, Kusec V, Romberg S, Triffitt JT 1999 Human bone marrow osteoprogenitors express estrogen receptor-alpha and bone morphogenetic proteins 2 and 4 mRNA during osteoblastic differentiation. J Cell Biochem 75:382392.
  • 60
    Ohnaka K, Shimoda S, Nawata H, Shimokawa H, Kaibuchi K, Iwamoto Y, Takayanagi R 2001 Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. Biochem Biophys Res Commun 287:337342.
  • 61
    Ghosh-Choudhury N, Choudhury GG, Harris MA, Wozney J, Mundy GR, Abboud SL, Harris SE 2001 Autoregulation of mouse BMP-2 gene transcription is directed by the proximal promoter element. Biochem Biophys Res Commun 286:101108.