SEARCH

SEARCH BY CITATION

REFERENCES

  • 1
    Fleisch H 1991 Bisphosphonates: Pharmacology and use in the treatment of tumour-induced hypercalcaemia and metastatic bone disease. Drugs 42:919944.
  • 2
    Liberman UA, Weiss SR, Broll J, Minne HW, Quan H, Bell NH, Rodriquez-Portales J, Downs RW, Dequeker J, Favus M, Seeman E, Recker RR, Capizzi T, Santora AC, Lombardi A, Shah RV, Hirsch LJ, Karpf DB 1995 Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med 333:14371443.
  • 3
    Delmas PD, Meunier PJ 1997 The management of Paget's disease of bone, N Engl J Med 336:558566.
  • 4
    Frith JC, Mönkkönen J, Blackburn GM, Russell RGG, Rogers MJ 1997 Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5′-β,γ-dichloromethylene) triphosphate, by mammalian cells in vitro. J Bone Miner Res 12:13581367.
  • 5
    Hughes DE, Wright KR, Uy HL, Sasaki A, Yoneda T, Roodman GD, Mundy GR, Boyce BF 1995 Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res 10:14781487.
  • 6
    Rogers MJ, Chilton KM, Coxon F, Lawry J, Smith MO, Suri S, Russell RGG 1996 Bisphosphonates induce apoptosis in mouse macrophage-like cells by a nitric-oxide-independent mechanism. J Bone Miner Res 11:14821491.
  • 7
    Luckman S, Ebetino FH, Russell RGG, Rogers MJ 1996 The structure-activity relationships of bisphosphonates for induction of macrophage apoptosis match those for inhibition of bone resorption. J Bone Miner Res 11(Suppl 1):S396 (abstract).
  • 8
    Luckman SP, Ebetino FH, Russell RGG, Rogers MJ 1997 The phosphonate groups of bisphosphonates are essential for inhibition of protein prenylation and induction of apoptosis. J Bone Miner Res 12:1521 (abstract).
  • 9
    Amin D, Cornell SA, Gustafson SK, Needle SJ, Ullrich JW, Bilder GE, Perrone MH 1992 Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis. J Lipid Res 33:16571663.
  • 10
    Amin D, Cornell SA, Perrone MH, Bilder GE 1996 1-hydroxy-3-(methylpentylamino)-propylidene-1,1-bisphosphonic acid as a potent inhibitor of squalene synthase. Drug Res 46:759762.
  • 11
    Goldstein JL, Brown MS 1990 Regulation of the mevalonate pathway. Nature 343:425430.
  • 12
    Schmidt RA, Schneider CJ, Glomset JA 1984 Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3, cell proteins. J Biol Chem 259:1017510180.
  • 13
    Casey PJ, Der Solski PA CJ, Buss JE 1989 p21Ras is modified by a farnesyl isoprenoid. Proc Nat Acad Sci USA 86:83238327.
  • 14
    Maltese WA 1990 Posttranslational modification of proteins by isoprenoids in mammalian cells. FASEB J 4:33193327.
  • 15
    Zhang FL, Casey PJ 1996 Protein prenylation: Molecular mechanisms and functional consequences. Annu Rev Biochem 65:241269.
  • 16
    Hancock JF, Magee AI, Childs JE, Marshall CJ 1989 All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57:11671177.
  • 17
    Kitten GT, Nigg EA 1991 The CAAX motif is required for isoprenylation, carboxyl methylation, and nuclear membrane association of lamin B2. J Cell Biol 113:1323.
  • 18
    Endo A, Kurada M, Tanzawa K 1976 Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B, fungal metabolites having hypocholesterolemic activity. FEBS Lett 72:323326.
  • 19
    Danesi R, Nardini D, Basolo F, del Tacca M, Samid D, Myers CE 1996 Phenylacetate inhibits protein isoprenylation and growth of the androgen-independent LNCaP prostate cancer cells transfected with the T24 Ha-ras oncogene. Mol Pharmacol 49:972979.
  • 20
    Prendergast GC, Davide JP, DeSolms SJ, Giuliani EA, Graham SL, Gibbs JB, Oliff A, Kohl NE 1994 Farnesyltransferase inhibition causes morphological reversion of Ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton. Mol Cell Biol 14:41934202.
  • 21
    Quesney-Huneeus V, Hughes Wiley M, Siperstein MD 1979 Essential role for mevalonate synthesis in DNA replication. Proc Natl Acad Sci USA 76:50565060.
  • 22
    Sinensky M, Logel J 1985 Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate. Proc Natl Acad Sci USA 82:32573261.
  • 23
    Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Der Cox AD CJ, Hamilton AD, Sebti SM 1995 Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signalling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. J Biol Chem 270:2680226806.
  • 24
    Perez-Sala D, Mollinedo F 1994 Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells. Biochem Biophys Res Commun 199:12091215.
  • 25
    Garret IR, Boyce BF, Oreffo ROC, Bonewald L, Poser J, Mundy GR 1990 Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85:632639.
  • 26
    Farnsworth CC, Wolda SL, Gelb MH, Glomset JA 1989 Human lamin B contains a farnesylated cysteine residue. J Biol Chem 264:2042220429.
  • 27
    Rogers MJ, Watts DJ, Russell RGG, Ji X, Xiong X, Blackburn GM, Bayless AV, Ebetino FH 1994 Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mould Dictyostelium discoideum. J Bone Miner Res 9:10291039.
  • 28
    Coxon FP, Russell RGG, Rogers MJ 1996 Bisphosphonates do not appear to cause apoptosis by inhibition of protein synthesis, chelation of intracellular zinc or inhibition of protein tyrosine phosphatases. J Bone Miner Res 11(Suppl 1):S396 (abstract).
  • 29
    Selander KS, Mönkkönen J, Karhukorpi E-K, Häkönen P, Hannuniemi R, Väänänen HK 1996 Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages. Mol Pharmacol 50:11271138.
  • 30
    Shipman CM, Rogers MJ, Apperley JF, Russell RGG, Croucher PI 1997 Bisphosphonates induce apoptosis in human myeloma cell lines: A novel anti-tumour activity. Br J Haematol 98:665672.
  • 31
    Neamati N, Fernandez A, Wright S, Kiefer J, McConkey DJ 1995 Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei. J Immunol 154:37883795.
  • 32
    Perez-Sala D, Collado-Escobar D, Mollinedo F 1996 Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endo-nuclease. J Biol Chem 11:62356242.
  • 33
    Ostad M, Shu W-P, Kong L, Liu BC-S 1996 Ha-Ras oncogene expression abrogates a pH dependent endonuclease activity of apoptosis in normal rat kidney cells. Cancer Lett 98:175182.
  • 34
    Coxon FP, Russell RGG, Rogers MJ 1997 Bisphosphonate-induced apoptosis in J774 macrophages is associated with intracellular acidification. J Bone Miner Res 12:1526 (abstract).
  • 35
    Brown RJ, Grove JE, Russell RGG, Ebetino FH, Watts DJ 1997 Bisphosphonate drugs inhibit farnesyl diphosphate synthase. Bone 20(Suppl 4):115S (abstract).
  • 36
    Sato M, Grasser W, Endo N, Akins R, Simmons H, Thompson DD, Golub E, Rodan GA 1991 Bisphosphonate action: Alendronate localisation in rat bone and effects on osteoclast ultrastructure. J Clin Invest 88:20952105.
  • 37
    Carano A, Teitelbaum SA, Konsek JD, Schlesinger PH, Blair HC 1990 Bisphosphonates directly inhibit the bone resorption activity of isolated avian osteoclasts in vitro. J Clin Invest 85:456461.
  • 38
    Sahni M, Guenther H, Fleisch H, Collin P, Martin TJ 1993 Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. J Clin Invest 91:20042011.
  • 39
    Vitte C, Fleisch H, Guenther HL 1996 Bisphosphonates induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorption. Endocrinology 137:23242333.
  • 40
    Boonekamp PM, der Wee-Pals LJA, van Wijk-van Lennep MML, Thesing CW, Bijovet OLM 1986 Two modes of action of bisphosphonates on osteoclastic resorption of mineralised matrix. Bone Miner 1:2739.
  • 41
    Löwik CWGM, van der Pluijm G, van der Wee-Pals LJA, Bloys van Treslong-de Groot H, Bijvoet OLM 1988 Migration and phenotypic transformation of osteoclast precursors into mature osteoclasts: The effect of a bisphosphonate. J Bone Miner Res 3:185192.
  • 42
    Ridley AJ, Hall A 1992 The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389399.
  • 43
    Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A 1992 The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401410.
  • 44
    Zerial M, Stenmark H 1993 Rab GTPases in vesicular transport. Curr Opin Cell Biol 5:613620.
  • 45
    Arends MJ, McGregor AH, Toft NJ, Brown EJH, Wyllie AH 1993 Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is asscoiated with endonuclease availability. Br J Cancer 68:11271133.
  • 46
    Zhang D, Udagawa N, Nakamura I, Murakami H, Saito S, Yamasaki K, Shibasaki Y, Morii N, Narumiya S, Takahashi N, Suda T 1995 The small GTP-binding protein, Rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts. J Cell Sci 108:22852292.
  • 47
    Palokangas H, Mulari M, Väänänen HK 1997 Endocytic pathway from the basal plasma membrane to the ruffled border membrane in bone-resorbing osteoclasts. J Cell Sci 110:17671780.
  • 48
    Lerner UH, Larsson A 1987 Effects of four bisphosphonates on bone resorption, lysosomal enzyme release, protein synthesis and mitotic activities on mouse calvarial bones in vitro. Bone 8:179189.