The authors have no conflict of interest.
Desmoid Tumor With Ossification in Chest Wall: Possible Involvement of BAMBI Promoter Hypermethylation in Metaplastic Bone Formation†
Article first published online: 21 MAR 2005
Copyright © 2005 ASBMR
Journal of Bone and Mineral Research
Volume 20, Issue 8, pages 1472–1477, August 2005
How to Cite
Kitazawa, S., Kitazawa, R., Obayashi, C. and Yamamoto, T. (2005), Desmoid Tumor With Ossification in Chest Wall: Possible Involvement of BAMBI Promoter Hypermethylation in Metaplastic Bone Formation. J Bone Miner Res, 20: 1472–1477. doi: 10.1359/jbmr.2005.20.8.1472
- Issue published online: 4 DEC 2009
- Article first published online: 21 MAR 2005
- Manuscript Revised: 20 APR 2005
- Manuscript Accepted: 20 APR 2005
- Manuscript Received: 30 JAN 2005
- BMP and activin membrane-bound inhibitor;
A rare case of desmoid-type fibromatosis with focal metaplastic bone in the chest wall suggested that enhanced responsiveness to BMP signaling by decreasing BAMBI expression through promoter hypermethylation plays a crucial role in the formation of metaplastic bone.
Introduction: Desmoid-type fibromatosis, originating from mesenchymal cells with myofibroblastic features, is a locally aggressive and frequently recurring infiltrative lesion. One such sporadic case with metaplastic ossification in the chest wall is presented.
Materials and Methods: A 43-year-old man was referred to the hospital with a gradually enlarging hard mass in the left anterolateral chest wall. A thoracotomy was carried out, and histopathological specimens were used for immunohistochemical, genetic, and methylation studies.
Results: Accumulation of altered β-catenin associated with a somatic heterozygous activating mutation in codon 41 was detected in the typical desmoid-type fibromatosis and at the ossifying focus. Among factors related to bone formation and the classical wnt-β-catenin signaling pathway, BMP and activin membrane-bound inhibitor (BAMBI) expression was specifically downregulated at the ossifying focus. Hypermethylation of the BAMBI promoter was observed in microdissected tissue from the ossifying focus but not in that from the typical desmoid-type fibromatosis.
Conclusions: Because both BMP and classical Wnt/β-catenin/LEF1 signaling cooperatively and mutually induce differentiation of mesenchymal cells into osteoblastic cells and promote bone formation, the epigenetic event leading to the enhanced responsiveness to BMP signaling may play a crucial role in the formation of metaplastic bone.