This study was conducted in the Human and Environmental Physiology Research Unit and funded by the Natural Sciences and Engineering Research Council (RGPIN-298159-2009) and Leaders Opportunity Fund from the Canada Foundation for Innovation (funds held by Kenny). Glen P. Kenny was supported by the University of Ottawa Research Chair Award. Jill M. Stapleton was supported by the Mitacs Accelerate Doctoral fellowship. Naoto Fujii was supported by the Human and Environmental Physiology Research Unit. Ryan McGinn was supported by the Queen Elizabeth II Graduate Scholarship in Science and Technology. Katherine McDonald was supported by the Ottawa Faculty of Health Sciences Student Research Bursary.
Age-related differences in postsynaptic increases in sweating and skin blood flow postexercise
Article first published online: 17 JUL 2014
© 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 2, Issue 7, July 2014
How to Cite
Age-related differences in postsynaptic increases in sweating and skin blood flow postexercise, Physiol Rep, 2 (7), 2014, e12078, doi:10.14814/phy2.12078, , , , ,
- Issue published online: 3 JUL 2014
- Article first published online: 17 JUL 2014
- Manuscript Accepted: 10 JUN 2014
- Manuscript Revised: 3 JUN 2014
- Manuscript Received: 9 MAY 2014
- Natural Sciences and Engineering Research Council. Grant Number: RGPIN-298159-2009
- Canada Foundation for Innovation
- University of Ottawa Research Chair Award
- Mitacs Accelerate Doctoral fellowship
- Human and Environmental Physiology Research Unit
- Queen Elizabeth II Graduate Scholarship in Science and Technology
- Ottawa Faculty of Health Sciences Student Research Bursary
- dose response;
- heat loss;
- nonthermal factors;
- skin perfusion;
- sweat rate
The influence of peripheral factors on the control of heat loss responses (i.e., sweating and skin blood flow) in the postexercise period remains unknown in young and older adults. Therefore, in eight young (22 ± 3 years) and eight older (65 ± 3 years) males, we examined dose-dependent responses to the administration of acetylcholine (ACh) and methacholine (MCh) for sweating (ventilated capsule), as well as to ACh and sodium nitroprusside (SNP) for cutaneous vascular conductance (CVC, laser-Doppler flowmetry, % of max). In order to assess if peripheral factors are involved in the modulation of thermoeffector activity postexercise, pharmacological agonists were perfused via intradermal microdialysis on two separate days: (1) at rest (DOSE) and (2) following a 30-min bout of exercise (Ex+DOSE). No differences in sweat rate between the DOSE and Ex+DOSE conditions at either ACh or MCh were observed for the young (ACh: P = 0.992 and MCh: P = 0.710) or older (ACh: P = 0.775 and MCh: P = 0.738) adults. Similarly, CVC was not different between the DOSE and Ex+DOSE conditions for the young (ACh: P = 0.123 and SNP: P = 0.893) or older (ACh: P = 0.113 and SNP: P = 0.068) adults. Older adults had a lower sweating response for both the DOSE (ACh: P = 0.049 and MCh: P = 0.006) and Ex+DOSE (ACh: P = 0.050 and MCh: P = 0.029) conditions compared to their younger counterparts. These findings suggest that peripheral factors do not modulate postexercise sweating and skin blood flow in both young and older adults. Additionally, sweat gland function is impaired in older adults, albeit the impairments were not exacerbated during postexercise recovery.