Information technology (IT) and the digital revolution continue to transform the biomedical research and health care practice landscape worldwide. While contributing to the dissemination of knowledge and the promise of reducing health care costs, access to this capability is not universal. Many communities, patients and health professionals worldwide do not have access to digital data repositories or even have Internet access. A major roadblock for developing nations is the cost of access and rapidly evolving IT tools. Language and “Internet literacy” are the other two major impediments in achieving access.