Association Between Serotonin Transporter Gene Polymorphism and Family History of Attempted and Completed Suicide


  • This project was funded in part by a grant from the Committee on Faculty Research Support, Florida State University.

Department of Psychology, Florida State University, Tallahassee, Florida 32306–1270. E-mail:


The purpose of this study was to examine the association of the serotonin transporter gene to family history of suicidality. Forty-seven volunteers responded to questionnaires about family history of suicide, and provided buccal swabs for analysis of the polymorphism. Allelic homozygocity (the short variant) was associated with family history of suicidality. These data, to be interpreted with the study's limitations in mind, suggest a link between the serotonin transporter gene polymorphism and suicide-related variables, which should be the focus of future research.