See also: Y-P Wang et al (June 2014)
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SIRT2 controls the pentose phosphate switch
Article first published online: 13 MAY 2014
© 2014 The Authors
The EMBO Journal
Volume 33, Issue 12, pages 1287–1288, 17 June 2014
How to Cite
Wu, L. E. and Sinclair, D. A. (2014), SIRT2 controls the pentose phosphate switch. The EMBO Journal, 33: 1287–1288. doi: 10.15252/embj.201488713
- Issue published online: 24 JUN 2014
- Article first published online: 13 MAY 2014
- Juvenile Diabetes Research Foundation
- The Schulak family and the Paul F. Glenn Foundation for Medical Research
The most common enzyme defect in humans is glucose-6-phosphate dehydrogenase (G6PD) deficiency, which affects more than 400 million people. G6PD shunts glucose into the pentose phosphate pathway (PPP) to generate nucleotides and reducing potential in the form of NADPH. In this issue, Wang et al (2014) show that G6PD activity is post-translationally regulated by SIRT2, a cytoplasmic NAD+-dependent deacetylase, thereby linking NAD+ levels to DNA repair and oxidative defences, and identifying potential new approaches to treating this common genetic disease.