SEARCH

SEARCH BY CITATION

In the above article, holo-cytochrome c-type synthase was used instead of holocytochrome c-type synthase, the official gene name. This error occurs in three places in the text and the correct sentences should read:

In the abstract:

Now we provide the evidence that non-canonical mitochondrial-dependent apoptosis explains the phenotype of microphthalmia with linear skin lesions (MLS), an X-linked developmental disorder caused by mutations in the holocytochrome c-type synthase (HCCS) gene.

In the introduction:

HCCS is a highly conserved gene from fungi to metazoans and encodes a mitochondrial holocytochrome c (Cytc)-type synthase, also known as ‘heme lyase’, located on the outer surface of the inner mitochondrial membrane (Schaefer et al, 1996; Schwarz & Cox, 2002).

In ‘The paper explained’ section:

We demonstrate that inactivation of holocytochrome c-type synthase (HCCS), a transcript important for the mitochondrial respiratory chain (MRC), is associated with unconventional activation of caspase-9 in the mitochondria triggered by MRC impairment and overproduction of reactive oxygen species.