New efficient copper fluoride-based catalyst for enantioselective hydrosilylation of ketones in aerobic conditions

Authors

  • James Courmarcel,

    1. Laboratoire de Chimie Organique et Médicinale, Université Catholique de Louvain, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium
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  • Naouël Mostefaï,

    1. Laboratoire de Chimie Organique et Médicinale, Université Catholique de Louvain, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium
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  • Sabine Sirol,

    1. Laboratoire de Chimie Organique et Médicinale, Université Catholique de Louvain, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium
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  • Sabine Choppin,

    1. Laboratoire de Chimie Organique et Médicinale, Université Catholique de Louvain, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium
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  • Olivier Riant

    Corresponding author
    1. Laboratoire de Chimie Organique et Médicinale, Université Catholique de Louvain, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium
    • Laboratoire de Chimie Organique et Médicinale, Université Catholique de Louvain, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium
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Abstract

A new copper(II) fluoride–chiral diphosphines catalytic system was developed. This one is very efficient and selective for the hydrosilylation of several substituted or unsubstituted aromatic ketones in so far as moderate to excellent enantioselectivities were obtained. An oxygen acceleration effect was observed that led us to propose a practical protocol with a low amount of catalyst.

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