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A Highly Selective Bicyclic Fluoroionophore for the Detection of Lithium Ions

Authors

  • Nantanit Wanichecheva,

    1. Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA
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  • John S. Benco,

    1. Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA
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  • Christopher R. Lambert,

    1. Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA
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  • W. Grant McGimpsey

    Corresponding author
    1. Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA
    • To whom correspondence should be addressed: Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA. Fax:508-831-5933; e-mail: wgm@wpi.edu

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  • This paper is part of a special issue dedicated to Professor J. C. (Tito) Scaiano on the occasion of his 60th birthday.

ABSTRACT

The macrobicyclic molecule, 21-(9-anthrylmethyl)-4,17,13,16-tetraoxa-1,10,21-triazabicyclo [8.8.5]tricosane-19,23-dione, I, was designed, synthesized and characterized as a fluoroionophore for the selective, optical detection of lithium ions. Compound I is based on a bridged diazacrown structure, which provides a semirigid binding framework. Binding takes place by electrostatic interactions between the oxygen atoms of the crown and the cation and is transduced to fluorescence emission from an attached anthracene fluorophore. In a 75:25 dichloromethane/tetrahydrofuran solvent mixture, I acts as an intramolecular electron transfer “off-on” fluorescence switch, exhibiting a greater than 190-fold enhancement in fluorescence emission intensity in the presence of lithium ions. The relative selectivity of I for lithium ions over sodium, potassium and ammonium ions was found to be log KLi+,Na+∼ -3,36, log KLi+K+∼ -1.77 and log KLi+NH4+∼ -2.78.

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