Current address: Division of Ophthalmology and Vision Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
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Visual Functional Effects of Constant Blue Light in a Retinal Degenerate Rat Model
Article first published online: 28 MAR 2007
DOI: 10.1562/2006-09-19-RA-1044
Additional Information
How to Cite
Thomas, B. B., Seiler, M. J., Aramant, R. B., Samant, D., Qiu, G., Vyas, N., Arai, S., Chen, Z. and Sadda, S. R. (2007), Visual Functional Effects of Constant Blue Light in a Retinal Degenerate Rat Model. Photochemistry and Photobiology, 83: 759–765. doi: 10.1562/2006-09-19-RA-1044
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Current address: Division of Ophthalmology and Vision Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
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Current address: Department of Anatomical Sciences & Neurobiology, University of Louisville, Louisville, KY, USA.
Publication History
- Issue published online: 9 MAY 2007
- Article first published online: 28 MAR 2007
- Received 19 September 2006; accepted 8 November 2006; published online 20 November 2006
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Abstract
Retinal degenerative conditions increase susceptibility to light damage, but rapid retinal degeneration (RD) models show less susceptibility to cyclic dim light. We investigated whether constant blue light (BL) exposure can eliminate the residual visual responses in a comparatively rapid RD rat model. Pigmented rhodopsin mutant S334ter line-3 rat pups (21 days old) were exposed for 5–6 consecutive days to constant BL. Visual behavior was evaluated with an optokinetic head tracking apparatus. Electrophysiological recordings were made from the superior colliculus (SC). S-antigen, red-green opsin and rhodopsin immunoreactive residual photoreceptors were counted. Following BL exposure, head tracking was significantly reduced at 0.25 cycles degree−1 in 38-day-old line 3 rats. With a 0.125 cycles degree−1 stimulus, the head tracking performance of 80-day-old BL rats were similar to that of 220-day-old no–BL-treated line-3 rats. SC recordings also revealed a significant decrease in the residual photoreceptor activity. Histological evaluation showed reduction of the rod population in the central area of the light-damaged retina. Exposure to constant BL considerably reduces the residual visual responses in a rapid degenerating RD rat model.