Impact of Pharmacy Counseling on Compliance and Effectiveness of Combination Lipid-Lowering Therapy in Patients Undergoing Coronary Artery Revascularization: A Randomized, Controlled Trial

Authors


Department of Pharmacy Practice, Creighton University School of Pharmacy and Allied Health Professions, 2500 California Plaza, Omaha, NE 68178.

Abstract

This randomized, controlled trial evaluated the impact of personalized follow-up on compliance rates in high-risk patients receiving combination lipid-lowering therapy over 2 years. A random sample of 30 patients 7–30 days after cardiac surgery had baseline fasting low-density lipoprotein levels higher than 130 mg/dl. All patients received lovastatin 20 mg/day and colestipol 5 g twice/day. Weekly telephone contact was made with each patient for 12 weeks. Short- and long-term compliance was assessed by pill and packet counts and refill records. Compliance and lipid profile results were significantly better in the intervention group (p<0.05) up to 2 years after the start of therapy than in the control group for all parameters except high-density lipoprotein. However this effect was not apparent during the first 12 weeks of therapy. Short-term telephone follow-up favorably affected compliance and lipid profile results up to 2 years after start of therapy.

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