Study Objective. To explore the association between exposure to acetaminophen (paracetamol) or nonsteroidal antiinflammatory drugs (NSAIDs) and risk of developing ovarian, breast, or colon cancer.
Design. Retrospective case-control study.
Setting. General practice offices.
Subjects. Four hundred eighty-three women with ovarian cancer and 1877 women matched for age, years of medical history in computer record, general practice attended, and calendar time; 3706 women with breast cancer and 14,155 matched control subjects; and 635 women with colon cancer and 2434 matched control subjects.
Intervention. United Kingdom-based General Practice Research Database was searched for women aged 50–89 years with a first-time diagnosis of ovarian, breast, or colon cancer and for matched controls to assess prescription analgesic exposure.
Measurements and Main Results. Regular acetaminophen exposure (30 prescriptions) was associated with a slightly decreased risk of developing breast (odds ratio [OR] 0.8, 95% confidence interval [CI] 0.7–1.0) but not ovarian (OR 1.0, 95% CI 0.6–1.5) or colon (OR 1.0, 95% CI 0.7–1.4) cancer. Regular NSAID exposure was associated with a reduced risk of colon (OR 0.5, 95% CI 0.3–0.9) but not ovarian or breast cancer.
Conclusion. We found no evidence for a decreased ovarian cancer risk for women with regular acetaminophen or NSAID exposure.