Excessive Somnolence from Aripiprazole in a Child
Article first published online: 16 JAN 2012
2004 Pharmacotherapy Publications Inc.
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Volume 24, Issue 4, pages 522–525, April 2004
How to Cite
Davenport, J. D., McCarthy, M. W. and Buck, M. L. (2004), Excessive Somnolence from Aripiprazole in a Child. Pharmacotherapy, 24: 522–525. doi: 10.1592/phco.24.5.522.33352
- Issue published online: 16 JAN 2012
- Article first published online: 16 JAN 2012
A 9-year-old girl was hospitalized with prolonged somnolence that began 3.5 hours after a single 15-mg dose of aripiprazole. After extensive workup, physical examinations were unremarkable, and all laboratory test results were within normal limits. The patient's extreme somnolence was attributed to aripiprazole, a new atypical antipsychotic prescribed for oppositional defiant disorder. In clinical trials, somnolence has been reported with a frequency of approximately 11%. However, the somnolence experienced by this child was severe, requiring 24-hour hospitalization for observation. Although a recent dose-finding study in 22 pediatric patients (≥ 6 yrs old) described weight-based dosages that were safe and well tolerated, dosing of aripiprazole in children has not been well established. Further studies are needed to identify optimal dosing of aripiprazole in pediatric patients.