Critical Rebound Methemoglobinemia After Methylene Blue Treatment: Case Report
Article first published online: 16 JAN 2012
2004 Pharmacotherapy Publications Inc.
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Volume 24, Issue 4, pages 538–540, April 2004
How to Cite
Fitzsimons, M. G., Gaudette, R. R. and Hurford, W. E. (2004), Critical Rebound Methemoglobinemia After Methylene Blue Treatment: Case Report. Pharmacotherapy, 24: 538–540. doi: 10.1592/phco.24.5.538.33356
- Issue published online: 16 JAN 2012
- Article first published online: 16 JAN 2012
- methylene blue;
A 39-year-old man developed significant methemoglobinemia after receiving benzocaine spray; he was treated appropriately with intravenous methylene blue. The patient's methemoglobin levels decreased, but this was followed by a critical rebound phenomenon to levels frequently considered near fatal. After further treatment with methylene blue, the patient's methemoglobin levels returned to normal. Clinicians need to be aware that a decreasing level of methemoglobin does not necessarily indicate that a crisis has passed and that further monitoring and treatment may be indicated.