Long-term Use of Atypical Antipsychotics in Bipolar Disorder
Article first published online: 6 JAN 2012
2006 Pharmacotherapy Publications Inc.
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Volume 26, Issue 8, pages 1134–1147, August 2006
How to Cite
Ehret, M. J. and Levin, G. M. (2006), Long-term Use of Atypical Antipsychotics in Bipolar Disorder. Pharmacotherapy, 26: 1134–1147. doi: 10.1592/phco.26.8.1134
- Issue published online: 6 JAN 2012
- Article first published online: 6 JAN 2012
- bipolar disorder;
- atypical antipsychotics;
- maintenance therapy
Bipolar disorder is a chronic disease that may require lifetime treatment. The maintenance therapy of bipolar disorder can be challenging for the treating clinician. Currently, according to the American Psychiatric Association (APA) guidelines, lithium, valproic acid, lamotrigine, carbamazepine, oxcarbazepine, and the antipsychotics are recommended for the maintenance treatment of bipolar disorder. The antipsychotics are recommended to be continued only if the clinician decides that they are necessary for the control of persistent psychosis or for prophylaxis against recurrence. Although the APA guidelines provide sufficient evidence for the use of these mood stabilizers, newer drugs such as the atypical antipsychotics are being investigated for use in the maintenance phase of treatment of bipolar disorder.