• 1
    Cairns JS, D'Souza MP. Chemokines and HIV-1 second receptors: the therapeutic connection. Nat Med 1998; 4:563568.
  • 2
    Fauci AS. Host factors and the pathogenesis of HIV-induced disease. Nature 1996; 384:529534.
  • 3
    Hoxie JA. Hematologic manifestations of AIDS. In HoffmanR, BenzEJ, ShatillSJ et al., eds. Hematology Basic Principles and Practice. New York: Churchill Livingstone, 1995; 21712200.
  • 4
    Lee B, Doranz BJ, Ratajczak MZ, et al. An intricate web: chemokine receptors, HIV-1 and hematopoiesis. Stem Cells 1998; 16:7988.
  • 5
    Moses A, Nelson J, Bagby GC. The influence of human immunodeficiency virus-1 on hematopoiesis. Blood 1998; 91:14791495.
  • 6
    Rollins BJ. Chemokines. Blood 1997; 90:909928.
  • 7
    Lee B, Ratajczak J, Doms RW, et al. Coreceptor/chemokine receptor expression on human hematopoietic cells: biological implications for HIV-1 infection. Blood 1999; 93:11451156.
  • 8
    Broxmeyer HE, Sherry B, Cooper S, et al. Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. J Immunol 1993; 150:34483458.
  • 9
    Su S, Mukaida N, Wang J, et al. Inhibition of immature erythroid progenitor cell proliferation by macrophage inflammatory protein-1α by interacting mainly with a C-C chemokine receptor, CCR1. Blood 1997; 90:605611.
  • 10
    de Wynter EA, Durig J, Cross MA, et al. Differential response of CD34+ cells isolated from cord blood and bone marrow to MIP-1α and the expression of MIP-1α receptors on these immature cells. Stem Cells 1998; 16:349356.
  • 11
    Aiuti A, Webb IJ, Bleul C, et al. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med 1997; 185:111120.
  • 12
    Bleul CC, Fuhlbridge RC, Casanovas JM, et al. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med 1996; 184:11011109.
  • 13
    Kim CH, Broxmeyer HE. In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: stromal cell-derived factor-1, steel factor, and the bone marrow environment. Blood 1998; 91:100110.
  • 14
    Ma Q, Jones D, Borghesani PR, et al. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4 and SDF-1 deficient mice. Proc Natl Acad Sci USA 1998; 95:94489453.
  • 15
    Mohle R, Bautz F, Rafii S, et al. The chemokine receptor CXCR4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood 1998; 91:45234530.
  • 16
    Nagasawa T, Hirota S, Tachibana K, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1998; 382:635638.
  • 17
    Zou Y, Kottmann AH, Kurod M, et al. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 1998; 393:595599.
  • 18
    Ratajczak J, Zhang Q, Pertusini E, et al. The role of insulin (INS) and insulin like growth factor-I (IGF-I) in regulating human erythropoiesis. Studies in vitro under serum free conditions—comparison to other cytokines and growth factors. Leukemia 1998; 12:371381.
  • 19
    Ratajczak J, Marlicz W, Machalinski B, et al. An improved serum free system for cloning human “pure” erythroid colonies. The role of the different growth factors and cytokines on BFU-E formation by the bone marrow and cord blood CD34+ cells. Folia Histochem Cytobiol 1998; 36:5560.
  • 20
    Ratajczak MZ, Plecher ChH, Marlicz W, et al. CD34+, Kit+, Rhodamine123low phenotype identifies a marrow cell population highly enriched for human hematopoietic stem cells. Leukemia 1998; 12:942950.
  • 21
    Kowalska MA, Ratajczak J, Hoxie J, et al. Platelet and megakaryocytes express the HIV co-receptor CXCR4 on their surface but do not respond to stromal derived factor (SDF)-1. Br J Haematol 1999; 104:220229.
  • 22
    Abe R, Vandenberghe P, Craighead N, et al. Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation. J Immunol 1995; 154:985997.
  • 23
    Rocca JDG, Biesen T, Daaka Y, et al. Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq- mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. J Biol Chem 1998; 272:1912519132.
  • 24
    De Jong MO, Wagemaker G, Wognum AW. Separation of myeloid and erythroid progenitors based on expression of CD34 and c-kit. Blood 1995; 86:40764085.
  • 25
    Majka M, Rozmyslowicz T, Lee B, et al. Bone marrow CD34+ cells and megakaryoblasts secrete β-chemokines; implications for infectability by M-tropic human immunodeficiency virus (R5 HIV). J Clin Invest 1999; 104:17391749.
  • 26
    Dutt P, Wang JF, Groopman JE. Stromal cell-derived factor-1α and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis. J Immunol 1998; 161:36523658.
  • 27
    Cashman JD, Eaves CJ, Sarris AH, et al. MCP-1, not MIP-1α, is the endogenous chemokine that cooperates with TGF-β to inhibit the cycling of primitive normal but not leukemic (CML) progenitors in long-term human marrow cultures. Blood 1998; 92:23382344.
  • 28
    Cook DN, Beck MA, Coffman TM, et al. Requirement of MIP-1α for an inflammatory response to viral infection. Science 1995; 269:15831585.
  • 29
    Mantel C, Kim YJ, Cooper S, et al. Polymerization of murine macrophage inflammatory protein 1α inactivates its myelosuppressive effects in vitro: the active form is monomer. Proc Natl Acad Sci USA 1993; 90:22322236.
  • 30
    Miller JS, McCullar V, Verfaille CM. Ex vivo culture of CD34+/Lin/DR cells in stroma-derived soluble factors, interleukin-3, and macrophage inflammatory protein-1α maintains not only myeloid but also lymphoid progenitors in a novel switch culture assay. Blood 1998; 91:45164522.
  • 31
    Patel VP, Kreider BL, Li Y, et al. Molecular and functional chracterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. J Exp Med 1997; 185:11631172.
  • 32
    Sanchez X, Cousins-Hodges B, Aguilar T, et al. Activation of HIV-1 coreceptor (CXCR4) mediates myelosuppression. J Biol Chem 1997; 272:2752927531.
  • 33
    Gewirtz AM, Zhang J, Ratajczak J, et al. Chemokine regulation of human megakaryocytopoiesis. Blood 1995; 86:25592567.
  • 34
    Zauli G, Vitale M, Gibellini D, et al. Inhibition of purified CD34+ hematopoietic progenitor cells by human immunodeficiency virus 1 or gp 120 mediated by endogenous transforming growth factor β1. J Exp Med 1996; 183:99108.
  • 35
    Wang JF, Liu ZY, Groopman JF. The β-chemokine receptor CXCR4 is expressed on the megakaryocytic lineage from progenitor to platelets and modulates migration and adhesion. Blood 1998; 92:756764.
  • 36
    Doranz BJ, Govit-Ferbas K, Sharron MP, et al. A small molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor. J Exp Med 1997; 186:13951400.