Bone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications

Authors

  • Paolo Bianco M.D.,

    Corresponding author
    1. Dipartimento di Medicina Sperimentale e Patologia, Universita' La Sapienza, Roma, Italy
    • Dipartimento di Medicina Sperimentale e Patologia, Universita' La Sapienza, Viale Regina Elena 324, 00161 Roma, Italy. Telephone: 39-06-444-1049; Fax: 39-06-494-0896
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  • Mara Riminucci,

    1. Dipartimento di Medicina Sperimentale, Universita' dell'Aquila, L'Aquila, Italy
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  • Stan Gronthos,

    1. Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
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  • Pamela Gehron Robey

    1. Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
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Abstract

Bone marrow stromal cells are progenitors of skeletal tissue components such as bone, cartilage, the hematopoiesis-supporting stroma, and adipocytes. In addition, they may be experimentally induced to undergo unorthodox differentiation, possibly forming neural and myogenic cells. As such, they represent an important paradigm of post-natal nonhematopoietic stem cells, and an easy source for potential therapeutic use. Along with an overview of the basics of their biology, we discuss here their potential nature as components of the vascular wall, and the prospects for their use in local and systemic transplantation and gene therapy.

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