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Characterization of Cells with a High Aldehyde Dehydrogenase Activity from Cord Blood and Acute Myeloid Leukemia Samples
Article first published online: 1 JUN 2005
DOI: 10.1634/stemcells.2004-0292
Copyright © 2005 AlphaMed Press
Additional Information
How to Cite
Pearce, D. J., Taussig, D., Simpson, C., Allen, K., Rohatiner, A. Z., Lister, T. A. and Bonnet, D. (2005), Characterization of Cells with a High Aldehyde Dehydrogenase Activity from Cord Blood and Acute Myeloid Leukemia Samples. STEM CELLS, 23: 752–760. doi: 10.1634/stemcells.2004-0292
Publication History
- Issue published online: 2 JAN 2009
- Article first published online: 1 JUN 2005
- Manuscript Accepted: 1 FEB 2005
- Manuscript Received: 21 OCT 2004
References
- 1, , et al. Human aldehyde dehydrogenase gene family. Eur J Biochem 1998; 251: 549–557.
- 2, . Aldehyde dehydrogenase gene superfamily: the 2002 update. Chem Biol Interact 2003; 143–144: 5–22.
- 3, , et al. Genetic modification of hematopoietic progenitor cells for combined resistance to 4-hydroperoxycyclophosphamide, vincristine, and daunorubicin. Acta Pharmacol Sin 2001; 22: 949–955.
- 4. Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid. Eur J Biochem 2000; 267: 4315–4324.
- 5, , et al. Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells. Blood 1990; 75: 1947–1950.
- 6, , et al. Assessment of aldehyde dehydrogenase in viable cells. Blood 1995; 85: 2742–2746.
- 7, , et al. Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity. Proc Natl Acad Sci U S A 1999; 96: 9118–9123.
- 8, , . Characterization of a hierarchy in human acute myeloid leukemia progenitor cells. Blood 1996; 87: 4754–4761.
- 9, . Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3: 730–737.
- 10, , . Aldehyde dehydrogenase involvement in a variant of the brown Norway rat acute myelocytic leukaemia (BNML) that acquired cyclophosphamide resistance in vivo. Eur J Cancer 1994; 30A: 2137–2143.
- 11, . Characterization of cytosolic aldehyde dehydrogenase from cyclophosphamide resistant L1210 cells. Cancer Res 1988; 48: 2963–2968.
- 12, , et al. Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene. Mol Ther 2001; 3: 88–96.
- 13, , et al. Expression of antisense RNA to aldehyde dehydrogenase class-1 sensitizes tumor cells to 4-hydroperoxycyclophosphamide in vitro. J Pharmacol Exp Ther 2000; 293: 390–396.
- 14, , et al. A newly discovered class of human hematopoietic cells with SCID-repopulating activity. Nat Med 1998; 4: 1038–1045.
- 15, , et al. Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity. Blood 2004; 104: 1648–1655.
- 16, , et al. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med 1997; 3: 1337–1345.
- 17, , et al. Functional characterization of highly purified human hematopoietic repopulating cells isolated based on aldehyde dehydrogenase activity. Blood 2004; 104: 1648–1655.
- 18, , et al. Isolation and characterization of human CD34−Lin− and CD34+Lin− hematopoietic stem cells using cell surface markers AC133 and CD7. Blood 2000; 95: 2813–2820.
- 19, , et al. Hoechst dye efflux reveals a novel CD7+CD34− lymphoid progenitor in human umbilical cord blood. Blood 2000; 96: 2125–2133.
- 20, , . Polyclonal normal hematopoietic progenitors in patients with acute myeloid leukemia. Exp Hematol 2002; 30: 721–728.
- 21, . Hoechst 33342 efflux identifies a sub-population of cytogenetically normal CD34+CD38− progenitor cells from patients with acute myeloid leukemia. Blood 2001; 97: 3882–3889.
- 22, , et al. A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia. Blood 2001; 98: 1166–1173.
- 23, , et al. All-trans retinoic acid in acute promyelocytic leukemia: long-term outcome and prognostic factor analysis from the North American Intergroup protocol. Blood 2002; 100: 4298–4302.
- 24. Differentiating therapy with all-trans retinoic acid in acute myeloid leukemia. Leukemia 1996; 10 (suppl 1):S12–S15.
- 25

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