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Polyamines Modulate Nitric Oxide Production and Cox-2 Gene Expression in Response to Mechanical Loading in Human Adipose Tissue-Derived Mesenchymal Stem Cells
Article first published online: 22 JUN 2006
DOI: 10.1634/stemcells.2005-0625
Copyright © 2006 AlphaMed Press
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How to Cite
Tjabringa, G. S., Vezeridis, P. S., Zandieh-Doulabi, B., Helder, M. N., Wuisman, P. I.J.M. and Klein-Nulend, J. (2006), Polyamines Modulate Nitric Oxide Production and Cox-2 Gene Expression in Response to Mechanical Loading in Human Adipose Tissue-Derived Mesenchymal Stem Cells. STEM CELLS, 24: 2262–2269. doi: 10.1634/stemcells.2005-0625
Publication History
- Issue published online: 2 JAN 2009
- Article first published online: 22 JUN 2006
- Manuscript Accepted: 15 JUN 2006
- Manuscript Received: 13 DEC 2005
References
- 1, , et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284:143–147.
- 2, , et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002; 13:4279–4295.
- 3, , et al. Multilineage cells from human adipose tissue: Implications for cell-based therapies. Tissue Eng 2001; 7:211–228.
- 4, , et al. Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure. Cytotherapy 2006; 8:166–177.
- 5, , et al. Adipose tissue-derived mesenchymal stem cells acquire bone cell-like responsiveness to fluid shear stress upon osteogenic stimulation. Tissue Eng 2005; 11:1780–1788.
- 6, , Mechanotransduction in bone: Do bone cells act as sensors of fluid flow? FASEB J 1994; 8:875–878.
- 7, Transport mechanism operating between blood supply and osteocytes in long bones. Nature 1977; 269:80–82.
- 8, An ex vivo model to study transport processes and fluid flow in loaded bone. J Biomech 2000; 33:247–254.
- 9, Strain amplification in the bone mechanosensory system. Am J Med Sci 1998; 316:184–188.
- 10, , et al. Sensitivity of osteocytes to biomechanical stress in vitro. FASEB J 1995; 9:441–445.
- 11, Mechanotransduction in bone–role of the lacuno-canalicular network. FASEB J 1999; 13(suppl:S101–S112.
- 12, , et al. Pulsating fluid flow increases prostaglandin production by cultured chicken osteocytes–a cytoskeleton-dependent process. Biochem Biophys Res Commun 1996; 225:62–68.
- 13, , et al. Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts–correlation with prostaglandin upregulation. Biochem Biophys Res Commun 1995; 217:640–648.
- 14Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo. J Bone Miner Res 1996; 11:1688–1693.
- 15, , et al. Role of nitric oxide and prostaglandins in mechanically induced bone formation. J Bone Miner Res 1998; 13:1039–1044.
- 16, , Cyclooxygenases: Structural, cellular, and molecular biology. Annu Rev Biochem 2000; 69:145–182.
- 17, , Mechanotransduction in bone cells proceeds via activation of COX-2, but not COX-1. Biochem Biophys Res Commun 2003; 305:677–683.
- 18, , Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 1996; 271:33157–33160.
- 19, , et al. Mechanical stress induces COX-2 mRNA expression in bone cells from elderly women. J Biomech 2000; 33:53–61.
- 20, , et al. Differential stimulation of prostaglandin G/H synthase-2 in osteocytes and other osteogenic cells by pulsating fluid flow. Biochem Biophys Res Commun 2000; 268:414–419.
- 21, Polyamine-mediated post-transcriptional regulation of COX-2. Biochimie 2002; 84:815–819.
- 22, , et al. Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells. Eur J Clin Invest 2001; 31:887–893.
- 23, , A perspective of polyamine metabolism. Biochem J 2003; 376:1–14.
- 24, , et al. The ornithine decarboxylase gene is essential for cell survival during early murine development. Mol Cell Biol 2001; 21:6549–6558.
- 25
- 26Role of polyamines in the control of cell proliferation and differentiation. Differentiation 1981; 19:1–20.
- 27, Polyamines and cancer: Old molecules, new understanding. Nat Rev Cancer 2004; 4:781–792.
- 28, , et al. A possible role for polyamines in cartilage in the mechanism of calcification. Biochim Biophys Acta 1986; 881:38–45.
- 29, , Role of polyamines in expression of the differentiated phenotype of chondrocytes: Effect of DL-alpha-hydrazino-delta-aminovaleric acid (DL-HAVA), an inhibitor of ornithine decarboxylase, on chondrocytes treated with parathyroid hormone. J Biochem (Tokyo) 1983; 93:591–598.
- 30, , Role of polyamines in expression of the differentiated phenotype of chondrocytes in culture. Med Biol 1981; 59:423–427.
- 31, , et al. 1,25-dihydroxyvitamin D3 modulates the expression of genes involved in polyamine catabolism in adipose tissue-derived mesenchymal stem cells. Transactions ORS 2005; 30:959.
- 32, , et al. Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene. Biochem J 2001; 355:45–49.
- 33, , et al. Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene. J Biol Chem 1999; 274:22095–22101.
- 34, , et al. Induction of spermidine/spermine N1-acetyltransferase by parathyroid hormone in rabbit costal chondrocytes in culture. J Biochem (Tokyo) 1985; 97:387–390.
- 35, Bone marrow stromal cells are load responsive in vitro. Calcif Tissue Int 1996; 58:101–108.
- 36, , et al. Biochemical analysis of the response in rat bone marrow cell cultures to mechanical stimulation. Biomed Mater Eng 1997; 7:369–377.
- 37, , et al. Rat tail suspension reduces messenger RNA level for growth factors and osteopontin and decreases the osteoblastic differentiation of bone marrow stromal cells. J Bone Miner Res 1995; 10:415–423.
- 38, , et al. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech 2003; 36:1087–1096.
- 39, , Fluid flow stimulates expression of osteopontin and bone sialoprotein by bone marrow stromal cells in a temporally dependent manner. Bone 2005; 36:1047–1055.
- 40, , et al. Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. Bone 2002; 31:186–194.

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