Functional Neuronal Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells
Article first published online: 11 JUN 2009
Copyright © 2006 AlphaMed Press
Volume 24, Issue 12, pages 2868–2876, December 2006
How to Cite
Tropel, P., Platet, N., Platel, J.-C., Noël, D., Albrieux, M., Benabid, A.-L. and Berger, F. (2006), Functional Neuronal Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells. STEM CELLS, 24: 2868–2876. doi: 10.1634/stemcells.2005-0636
- Issue published online: 11 JUN 2009
- Article first published online: 11 JUN 2009
- Manuscript Accepted: 27 JUL 2006
- Manuscript Received: 19 DEC 2005
- 1Bone marrow transdifferentiation in brain after transplantation: A retrospective study. Lancet 2004; 363: 1432–1437., , et al.
- 2From marrow to brain: Expression of neuronal phenotypes in adult mice. Science 2000; 290: 1775–1779., , et al.
- 3Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains. Proc Natl Acad Sci U S A 2003; 100: 2088–2093., , et al.
- 4Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 2003; 425: 968–973., , et al.
- 5Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science 2002; 297:1299., , et al.
- 6Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002; 297: 2256–2259., , et al.
- 7Something in the eye of the beholder. Science 2002; 298: 361–362 author reply 362–363., , et al.
- 8Developmental biology: Ignoratio elenchi: Red herrings in stem cell research. Science 2005; 308: 1121–1122., , et al.
- 9Comment on “Little evidence for developmental plasticity of adult hematopoietic stem cells”. Science 2003; 299: 1317 author reply 1317., , .
- 10Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143–147., , et al.
- 11The STRO-1+ marrow cell population is multipotential. Cells Tissues Organs 2002; 170: 73–82., , et al.
- 12Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999; 103: 697–705., , et al.
- 13Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 1995; 18: 1417–1426., , .
- 14Autologous mesenchymal stem cell-mediated repair of tendon. Tissue Eng 1999; 5: 267–277., , et al.
- 15Cell death and long-term maintenance of neuron-like state after differentiation of rat bone marrow stromal cells: A comparison of protocols. Brain Res 2003; 991: 46–55., , et al.
- 16Neural cells derived from adult bone marrow and umbilical cord blood. J Neurosci Res 2002; 69: 880–893..
- 17Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci 1999; 19: 8487–8497., , et al.
- 18Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002; 418: 41–49., , et al.
- 19Isolation and characterisation of mesenchymal stem cells from adult mouse bone marrow. Exp Cell Res 2004; 295: 395–406., , et al.
- 20Isolation of mouse marrow mesenchymal progenitors by a novel and reliable method. Stem Cells 2003; 21: 527–535., , et al.
- 21Formation of postsynaptic-like membranes during differentiation of embryonic stem cells in vitro. Exp Cell Res 1998; 239: 214–225., , et al.
- 22Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol 2000; 18: 675–679., , et al.
- 23Na+ channel-mediated Ca2+ entry leads to glutamate secretion in mouse neocortical preplate. Proc Natl Acad Sci U S A 2005; 102: 19174–19179., , et al.
- 24Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 2001; 3: 778–784., , et al.
- 25Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat Med 2003; 9: 439–447., , et al.
- 26Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes. Nat Biotechnol 1998; 16: 1033–1039., , et al.
- 27Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection. J Cell Biochem 2003; 89: 1235–1249., , et al.
- 28Kinesin-mediated transport of neurofilament protein oligomers in growing axons. J Cell Sci 1999; 112 Pt 21: 3799–3814., , .
- 29Major phosphorylation site (Ser55) of neurofilament L by cyclic AMP-dependent protein kinase in rat primary neuronal culture. J Neurochem 2000; 74: 949–959., , et al.
- 30Prospective cell sorting of embryonic rat neural stem cells and neuronal and glial progenitors reveals selective effects of basic fibroblast growth factor and epidermal growth factor on self-renewal and differentiation. J Neurosci 2003; 23: 240–251., , et al.
- 31Molecular biology and ontogeny of glutamate receptors in the mammalian central nervous system. J Child Neurol 2004; 19: 343–360 discussion 361., , .
- 32Effects of veratridine on sodium currents and fluxes. Rev Physiol Biochem Pharmacol 1998; 133: 1–54..
- 33Activity-dependent homeostatic specification of transmitter expression in embryonic neurons. Nature 2004; 429: 523–530., , et al.
- 34Calcium channels involved in K+- and veratridine-induced increase of cytosolic calcium concentration in human cerebral cortical synaptosomes. J Pharmacol Exp Ther 1999; 290: 1126–1131., , et al.
- 35Dopamine receptor-interacting proteins: The Ca(2+) connection in dopamine signaling. Trends Pharmacol Sci 2003; 24: 486–492., , et al.
- 36Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture. J Neurosci 1998; 18: 7856–7868., , et al.
- 37Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex. Proc Natl Acad Sci U S A 2004; 101: 2596–2600., , et al.
- 38Glutamate signaling in peripheral tissues. Eur J Biochem 2004; 271: 1–13., , et al.
- 39Role of astrocytes in cerebrovascular regulation. J Appl Physiol 2006; 100: 307–317., , .
- 40AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia. J Neurosci 2000; 20: 251–258., , et al.
- 41Progenitor cells of the testosterone-producing Leydig cells revealed. J Cell Biol 2004; 167: 935–944., , et al.
- 42The intermediate filament protein nestin occurs transiently in differentiating testis of rat and mouse. Differentiation 1997; 61: 243–249., , et al.
- 43Nestin expression during mouse eye and lens development. Mech Dev 2000; 94: 287–291., , et al.
- 44Nestin expression in hair follicle sheath progenitor cells. Proc Natl Acad Sci U S A 2003; 100: 9958–9961., , et al.
- 45Myogenesis and the intermediate filament protein, nestin. Dev Biol 1994; 165: 216–228., , .
- 46Skeletal muscle satellite cells can spontaneously enter an alternative mesenchymal pathway. J Cell Sci 2004; 117: 5393–5404., , .
- 47The expression of intermediate filament protein nestin as related to vimentin and desmin in regenerating skeletal muscle. J Neuropathol Exp Neurol 2001; 60: 588–597., , et al.
- 48Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart. J Cell Biol 2005; 170: 1135–1146., , et al.
- 49Nestin-expressing neural stem cells identified in the scar following myocardial infarction. J Cell Physiol 2005; 204: 51–62., , et al.
- 50Nestin expression in pancreatic exocrine cell lineages. Mech Dev 2004; 121: 3–14., , et al.
- 51Nestin-expressing cells in the pancreatic islets of Langerhans. Biochem Biophys Res Commun 2000; 271: 116–119., .
- 52Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 2001; 50: 521–533., , et al.
- 53Cells enriched in markers of neural tissue-committed stem cells reside in the bone marrow and are mobilized into the peripheral blood following stroke. Leukemia 2006; 20: 18–28., , et al.
- 54Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential. Blood 2004; 103: 1662–1668., , et al.
- 55Bone marrow-derived mesenchymal stem cells already express specific neural proteins before any differentiation. Differentiation 2004; 72: 319–326., , et al.
- 56In vitro differentiation of size-sieved stem cells into electrically active neural cells. Stem Cells 2002; 20: 522–529., , et al.
- 57Induction of neuronal markers in bone marrow cells: Differential effects of growth factors and patterns of intracellular expression. Exp Neurol 2003; 184: 78–89., , et al.
- 58Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation. Stem Cells 2006; 24: 1054–1064., , et al.
- 59Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells. Proc Natl Acad Sci U S A 2005; 102: 4789–4794., , et al.
- 60Plasticity of cultured mesenchymal stem cells: Switch from nestin-positive to excitable neuron-like phenotype. Stem Cells 2005; 23: 392–402., , et al.
- 61Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J Clin Invest 2004; 113: 1701–1710., , et al.
- 62Regulation of neural markers nestin and GFAP expression by cultivated bone marrow stromal cells. J Cell Sci 2003; 116: 3295–3302., , et al.
- 63Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nat Neurosci 1999; 2: 246–253., , et al.
- 64FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells. J Cell Physiol 2005; 203: 398–409., , et al.
- 65Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model. J Cell Sci 2000; 113 Pt 7: 1161–1166., , .
- 66Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2. Exp Cell Res 2003; 287: 98–105., , et al.
- 67IGF-I does not affect the proliferation or early osteogenic differentiation of human marrow stromal cells. Bone 2003; 33: 80–89., , et al.
- 68Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells. Stem Cells 2006; 24: 462–471., , et al.
- 69Basic fibroblast growth factor enhances PPARgamma ligand-induced adipogenesis of mesenchymal stem cells. FEBS Lett 2004; 577: 277–283., , et al.
- 70Marrow stromal cells, mitosis, and neuronal differentiation: Stem cell and precursor functions. Stem Cells 2003; 21: 437–448., , .
- 71Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis. J Neurosci Res 2002; 69: 908–917., , .
- 72Expansion of human adult stem cells from bone marrow stroma: Conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells 2002; 20: 530–541., , et al.
- 73Induction of bone marrow stromal cells to neurons: Differentiation, transdifferentiation, or artifact? J Neurosci Res 2004; 77: 174–191., , .
- 74Common precursors for neural and mesectodermal derivatives in the cephalic neural crest. Development 1991; 112: 301–305., , .
- 75Multipotentiality of the neural crest. Curr Opin Genet Dev 2003; 13: 529–536., .
- 76Bone marrow innervation regulates cellular retention in the murine haemopoietic system. Br J Haematol 1997; 98: 569–577., , et al.
- 77Noradrenergic and cholinergic innervation of the bone marrow. Int J Mol Med 2002; 10: 77–80., , et al.
- 78Human bone marrow angiogenesis: In vitro modulation by substance P and neurokinin A. Br J Haematol 2002; 119: 1083–1089., , et al.
- 79Effect of adrenergic agents on hematopoiesis after syngeneic bone marrow transplantation in mice. Blood 1992; 80: 1178–1182., , .
- 80Ultrastructural morphometric study of efferent nerve terminals on murine bone marrow stromal cells, and the recognition of a novel anatomical unit: The “neuro-reticular complex”. Am J Anat 1990; 187: 261–276., .
- 81The innervation of the bone marrow in laboratory animals. Am J Anat 1968; 123: 315–328..
- 82Stem cells and pattern formation in the nervous system: The possible versus the actual. Neuron 2001; 30: 19–35..
- 83Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro. Neuron 2003; 40: 485–499., , et al.
- 84The chiaroscuro stem cell: A unified stem cell theory. Blood 2002; 100: 4266–4271., , .
- 85The evolving concept of a stem cell: Entity or function? Cell 2001; 105: 829–841., , .