research-article
You have full text access to this OnlineOpen article
Placenta-Derived Multipotent Cells Exhibit Immunosuppressive Properties That Are Enhanced in the Presence of Interferon-γ
Article first published online: 1 NOV 2006
DOI: 10.1634/stemcells.2006-0071
Copyright © 2006 AlphaMed Press
Additional Information
How to Cite
Chang, C.-J., Yen, M.-L., Chen, Y.-C., Chien, C.-C., Huang, H.-I., Bai, C.-H. and Yen, B. L. (2006), Placenta-Derived Multipotent Cells Exhibit Immunosuppressive Properties That Are Enhanced in the Presence of Interferon-γ. STEM CELLS, 24: 2466–2477. doi: 10.1634/stemcells.2006-0071
Publication History
- Issue published online: 2 JAN 2009
- Article first published online: 1 NOV 2006
- Manuscript Accepted: 14 JUL 2006
- Manuscript Received: 3 FEB 2006
References
- 1, , et al. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282:1145–1147.
- 2, , et al. Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro. Nat Biotechnol 2000; 18:399–404.
- 3, , et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284:143–147.
- 4, , et al. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 2000; 18:307–316.
- 5, , et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 2004; 94:92–95.
- 6, , et al. Stem cell therapy in amyotrophic lateral sclerosis: A methodological approach in humans. Amyotroph Lateral Scler Other Motor Neuron Disord 2003; 4:158–161.
- 7, , et al. Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant 2002; 30:215–222.
- 8, , et al. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant 2005; 11:389–398.
- 9Introduction to graft-versus-host disease. Biol Blood Marrow Transplant 2005;11 2 suppl 2 ():17–20.
- 10, , et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002; 30:42–48.
- 11, , et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002; 99:3838–3843.
- 12, , et al. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood 2003; 102:3837–3844.
- 13, , et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003; 101:3722–3729.
- 14, , et al. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation. Transplantation 2003; 75:389–397.
- 15, , et al. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood 2005; 105:2821–2827.
- 16, , et al. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 2005; 105:2214–2219.
- 17, , et al. Mesenchymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaemagglutinin-activated lymphocytes. Scand J Immunol 2004; 60:307–315.
- 18, , et al. Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 2006; 24:386–398.
- 19, , et al. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation 2003; 76:1208–1213.
- 20, , et al. Mesenchymal stem cells induce apoptosis of activated T cells. Leukemia 2005; 19:1597–1604.
- 21, , et al. Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. Eur J Immunol 2005; 35:1482–1490.
- 22, Stem cells and aging: Expanding the possibilities. Mech Ageing Dev 2001; 122:713–734.
- 23, , et al. Human placenta-derived cells have mesenchymal stem/progenitor cell potential. Stem Cells 2004; 22:649–658.
- 24, , et al. Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells 2004; 22:1338–1345.
- 25, , et al. Isolation of multipotent cells from human term placenta. Stem Cells 2005; 23:3–9.
- 26, , et al. Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: Analysis of engraftment and acute graft-versus-host disease. Blood 1996; 88:795–802.
- 27
- 28, , et al. Engineered antibody Fc variants with enhanced effector function. Proc Natl Acad Sci U S A 2006; 103:4005–4010.
- 29, , et al. In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Blood 2000; 95:3106–3112.
- 30, , et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998; 281:1191–1193.
- 31, , et al. HLA-G and immune tolerance in pregnancy. FASEB J 2005; 19:681–693.
- 32, , et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 2001; 182:18–32.
- 33, , et al. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299:1057–1061.
- 34, , et al. Decreased interleukin 10 and increased interferon-gamma production in patients with chronic graft-versus-host disease after allogeneic bone marrow transplantation. Bone Marrow Transplant 1997; 19:691–695.
- 35, , et al. B7–H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999; 5:1365–1369.
- 36, , et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000; 192:1027–1034.
- 37, , et al. Human embryonic stem cells and their differentiated derivatives are less susceptible for immune rejection than adult cells. Stem Cells 2006; 24:221–229.
- 38, , et al. Characterization of the expression of MHC proteins in human embryonic stem cells. Proc Natl Acad Sci U S A 2002; 99:9864–9869.
- 39, , et al. Human embryonic stem cells possess immune-privileged properties. Stem Cells 2004; 22:448–456.
- 40, , et al. Immunologic properties of human fetal mesenchymal stem cells. Am J Obstet Gynecol 2004; 190:239–245.
- 41, , et al. Immunomodulatory effect of human adipose tissue-derived adult stem cells: Comparison with bone marrow mesenchymal stem cells. Br J Haematol 2005; 129:118–129.
- 42, , et al. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004; 103:4619–4621.
- 43, , et al. Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype. Haematologica 2005; 90:516–525.
- 44, Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005; 105:1815–1822.
- 45, , et al. Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis. J Exp Med 2004; 200:1123–1134.
- 46, Dendritic cells and the control of immunity. Nature 1998; 392:245–252.
- 47, , Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 1997; 9:10–16.
- 48, , et al. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 2005; 105:4120–4126.
- 49, , et al. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol 2004; 5:1124–1133.
- 50, , et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004; 363:1439–1441.

1549-4918/asset/olbannerleft.jpg?v=1&s=699114e871887e6b838f6a1c657fe256cfe127a6)
1549-4918/asset/olbannerright.gif?v=1&s=603f8f2ab5cd9d4f783c231915608956af51aeea)
1549-4918/asset/cover.gif?v=1&s=51ac62b4272cd760b70f0cb1539035cc40743da6)