• 1
    Rubinstein P, Carrier C, Scaradavou A et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med 1998; 339:15651577.
  • 2
    Madrigal JA, Cohen SB, Gluckman E et al. Does cord blood transplantation result in lower graft-versus-host disease? It takes more than two to tango. Hum Immunol 1997; 56:15.
  • 3
    Sorg RV, Kogler G, Wernet P. Identification of cord blood dendritic cells as an immature CD11c population. Blood 1999; 93:23022307.
  • 4
    Cohen SB, Madrigal JA. Immunological and functional differences between cord and peripheral blood. Bone Marrow Transplant 1998; 21(suppl 3:S912.
  • 5
    Borras FE, Matthews NC, Lowdell MW et al. Identification of both myeloid CD11c+ and lymphoid CD11c dendritic cell subsets in cord blood. Br J Haematol 2001; 113:925931.
  • 6
    Sato N, Sawada K, Koizumi K et al. In vitro expansion of human peripheral blood CD34+ cells. Blood 1993; 82:36003609.
  • 7
    Petzer AL, Hogge DE, Landsdorp PM et al. Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium. Proc Natl Acad Sci U S A 1996; 93:14701474.
  • 8
    Kobari L, Pflumio F, Giarratana M et al. In vitro and in vivo evidence for the long-term multilineage (myeloid, B, NK, and T) reconstitution capacity of ex vivo expanded human CD34(+) cord blood cells. Exp Hematol 2000; 28:14701480.
  • 9
    Murray LJ, Young JC, Osborne LJ et al. Thrombopoietin, flt3, and kit ligands together suppress apoptosis of human mobilized CD34+ cells and recruit primitive CD34+ Thy-1+ cells into rapid division. Exp Hematol 1999; 27:10191028.
  • 10
    Luens KM, Travis MA, Chen BP et al. Thrombopoietin, kit ligand, and flk2/flt3 ligand together induce increased numbers of primitive hematopoietic progenitors from human CD34+Thy-1+Lin cells with preserved ability to engraft SCID-hu bone. Blood 1998; 91:12061215.
  • 11
    Conneally E, Cashman J, Petzer A et al. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc Natl Acad Sci U S A 1997; 94:98369841.
  • 12
    Piacibello W, Sanavio F, Severino A et al. Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34(+) cord blood cells after ex vivo expansion: Evidence for the amplification and self-renewal of repopulating stem cells. Blood 1999; 93:37363749.
  • 13
    Caux C, Dezutter-Dambuyant C, Schmitt D et al. GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature 1992; 360:258261.
  • 14
    Rosenzwajg M, Canque B, Gluckman JC. Human dendritic cell differentiation pathway from CD34+ hematopoietic precursor cells. Blood 1996; 87:535544.
  • 15
    Rosenzwajg M, Camus S, Guigon M et al. The influence of interleukin (IL)-4, IL-13, and Flt3 ligand on human dendritic cell differentiation from cord blood CD34+ progenitor cells. Exp Hematol 1998; 26:6372.
  • 16
    Robin C, Bennaceur-Griscelli A, Louache F et al. Identification of human T-lymphoid progenitor cells in CD34+ CD38low and CD34+ CD38+ subsets of human cord blood and bone marrow cells using NOD-SCID fetal thymus organ cultures. Br J Haematol 1999; 104:809819.
  • 17
    Giarratana MC, Verge V, Schmitt C et al. Presence of primitive lymphoid progenitors with NK or B potential in ex vivo expanded bone marrow cell cultures. Exp Hematol 2000; 28:4654.
  • 18
    Douay L, Giarratana MC, Drouet X et al. The role of recombinant haematopoietic growth factors in human long-term bone marrow culture in serum-free medium. Br J Haematol 1991; 79:2732.
  • 19
    Giarratana MC, Kobari L, Neildez Nguyen TM et al. Cell culture bags allow a large extent of ex vivo expansion of LTC-IC and functional mature cells which can subsequently be frozen: Interest for a large-scale clinical applications. Bone Marrow Transplant 1998; 22:707715.
  • 20
    Kerre TC, De Smet G, De Smedt M et al. Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells. Blood 2002; 99:16201626.
  • 21
    Kobari L, Giarratana MC, Poloni A et al. Flt 3 ligand, MGDF, Epo and G-CSF enhance ex vivo expansion of hematopoietic cell compartments in the presence of SCF, IL-3 and IL-6. Bone Marrow Transplant 1998; 21:759767.
  • 22
    Reid CD, Stackpoole A, Meager A et al. Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow. J Immunol 1992; 149:26812688.
  • 23
    McCune JM, Namikawa R, Kaneshima H et al. The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function. Science 1988; 241:16321639.
  • 24
    Plum J, De Smedt M, Defresne MP et al. Human CD34+ fetal liver stem cells differentiate to T cells in a mouse thymic microenvironment. Blood 1994; 84:15871593.
  • 25
    Hori T, Cupp J, Wrighton N et al. Identification of a novel human thymocyte subset with a phenotype of CD3 CD4+ CD8 alpha + beta-1. Possible progeny of the CD3 CD4 CD8 subset. J Immunol 1991; 146:40784084.
  • 26
    Robin C, Pflumio F, Vainchenker W et al. Identification of lymphomyeloid primitive progenitor cells in fresh human cord blood and in the marrow of nonobese diabetic-severe combined immunodeficient (NOD-SCID) mice transplanted with human CD34(+) cord blood cells. J Exp Med 1999; 189:16011610.
  • 27
    Tanaka T, Kitamura F, Nagasaka Y et al. Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice. J Exp Med 1993; 178:11031107.
  • 28
    Banchereau J, Briere F, Caux C et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18:767811.
  • 29
    Chen W, Antonenko S, Sederstrom JM et al. Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors. Blood 2004; 103:25472553.
  • 30
    Res P, Blom B, Hori T et al. Downregulation of CD1 marks acquisition of functional maturation of human thymocytes and defines a control point in late stages of human T cell development. J Exp Med 1997; 185:141151.
  • 31
    Yeoman H, Gress RE, Bare CV et al. Human bone marrow and umbilical cord blood cells generate CD4+ and CD8+ single-positive T cells in murine fetal thymus organ culture. Proc Natl Acad Sci U S A 1993; 90:1077810782.
  • 32
    Yahata T, Ando K, Nakamura Y et al. Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice. J Immunol 2002; 169:204209.
  • 33
    Hiramatsu H, Nishikomori R, Heike T et al. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood 2003; 102:873880.
  • 34
    Ferrara JL. Pathogenesis of acute graft-versus-host disease: Cytokines and cellular effectors. J Hematother Stem Cell Res 2000; 9:299306.
  • 35
    Shlomchik WD, Couzens MS, Tang CB et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science 1999; 285:412415.
  • 36
    Shpall EJ, Quinones R, Giller R et al. Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant 2002; 8:368376.
  • 37
    Arrighi JF, Hauser C, Chapuis B et al. Long-term culture of human CD34(+) progenitors with FLT3-ligand, thrombopoietin, and stem cell factor induces extensive amplification of a CD34(−)CD14(−) and a CD34(-)CD14(+) dendritic cell precursor. Blood 1999; 93:22442252.
  • 38
    Urbini B, Arpinati M, Bonifazi F et al. Allogeneic graft CD34(+) cell dose correlates with dendritic cell dose and clinical outcome, but not with dendritic cell reconstitution after transplant. Exp Hematol 2003; 31:959965.
  • 39
    Cohena Y, Nagler A. Hematopoietic stem-cell transplantation using umbilical-cord blood. Leuk Lymphoma 2003; 44:12871299.