research-article
You have full text access to this OnlineOpen article
Angiogenic Effects of Human Multipotent Stromal Cell Conditioned Medium Activate the PI3K-Akt Pathway in Hypoxic Endothelial Cells to Inhibit Apoptosis, Increase Survival, and Stimulate Angiogenesis
Article first published online: 31 MAY 2007
DOI: 10.1634/stemcells.2006-0686
Copyright © 2007 AlphaMed Press
Additional Information
How to Cite
Hung, S.-C., Pochampally, R. R., Chen, S.-C., Hsu, S.-C. and Prockop, D. J. (2007), Angiogenic Effects of Human Multipotent Stromal Cell Conditioned Medium Activate the PI3K-Akt Pathway in Hypoxic Endothelial Cells to Inhibit Apoptosis, Increase Survival, and Stimulate Angiogenesis. STEM CELLS, 25: 2363–2370. doi: 10.1634/stemcells.2006-0686
Publication History
- Issue published online: 2 JAN 2009
- Article first published online: 31 MAY 2007
- Manuscript Accepted: 18 MAY 2007
- Manuscript Received: 26 OCT 2006
References
- 1. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997; 276:71–74.
- 2, , et al. Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol 2004; 287:H2670–2676.
- 3, , et al. A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats. Brain Res 2004; 1007:1–9.
- 4, , et al. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum 2003; 48:3464–3474.
- 5, , et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999; 5:309–313.
- 6, , et al. Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant 2002; 30:215–222.
- 7, , et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: The BOOST randomised controlled clinical trial. Lancet 2004; 364:141–148.
- 8, , et al. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res 2003; 92:692–699.
- 9, , et al. Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation 2005; 111:150–156.
- 10, , et al. Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 2004; 109:1543–1549.
- 11, , et al. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 2005; 11:367–368.
- 12, , et al. Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction. Ann Thorac Surg 2005; 80:229–236.
- 13, , et al. Expansion of human adult stem cells from bone marrow stroma: Conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells 2002; 20:530–541.
- 14, , et al. Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266. Blood 1991; 77:587–593.
- 15, , et al. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 1997; 275:665–668.
- 16, , et al. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci U S A 2000; 97:1749–1753.
- 17, , et al. Bone marrow stromal cells can provide a local environment that favors migration and formation of tubular structures of endothelial cells. Tissue Eng 2005; 11:896–903.
- 18, , et al. Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J Hematother Stem Cell Res 2000; 9:841–848.
- 19, , et al. Hepatocyte growth factor is constitutively produced by human bone marrow stromal cells and indirectly promotes hematopoiesis. Blood 1997; 89:1560–1565.
- 20, , et al. Expression of neurotrophins and their receptors in human bone marrow. Am J Pathol 1999; 154:405–415.
- 21, , et al. Regulation of angiogenesis by glycogen synthase kinase-3beta. J Biol Chem 2002; 277:41888–41896.
- 22, , et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 2002; 419:316–321.
- 23, , et al. Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest 2005; 115:2382–2392.
- 24, , et al. Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: Next-generation chemokine therapy for therapeutic neovascularization. Circulation 2004; 109:2454–2461.

1549-4918/asset/olbannerleft.jpg?v=1&s=699114e871887e6b838f6a1c657fe256cfe127a6)
1549-4918/asset/olbannerright.gif?v=1&s=603f8f2ab5cd9d4f783c231915608956af51aeea)
1549-4918/asset/cover.gif?v=1&s=51ac62b4272cd760b70f0cb1539035cc40743da6)