Directed Sibling Cord Blood Banking for Transplantation: The 10-Year Experience in the National Blood Service in England

Authors

  • Jon Smythe MPhil, Ph.D.,

    Corresponding author
    1. Stem Cells and Immunotherapies Department, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
    • Stem Cells and Immunotherapies Department, National Blood Service, NHS Blood and Transplant, Headington, Oxford OX3 9BQ, U.K. Telephone: 44-0-1865-44-79-67; Fax: 44-0-1865-44-79-77
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  • Sue Armitage,

    1. National Health Service Cord Blood Bank, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
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  • Dorothy McDonald,

    1. Stem Cells and Immunotherapies Department, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
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  • Derwood Pamphilon,

    1. Bristol Institute of Transfusion Sciences, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
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  • Martin Guttridge,

    1. Stem Cells and Immunotherapies Department, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
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  • Juliette Brown,

    1. Histocompatibility and Immunogenetics Department, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
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  • Ann Green,

    1. Histocompatibility and Immunogenetics Department, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
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  • Colin Brown,

    1. Histocompatibility and Immunogenetics Department, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
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  • Ruth M. Warwick,

    1. Tissue Services Department, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
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  • Alan Lankester,

    1. Stem Cells and Immunotherapies Department, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
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  • Deirdre Fehily,

    1. National Health Service Cord Blood Bank, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
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  • Marcela Contreras,

    1. Division of Diagnostics, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
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  • Cristina Navarrete,

    1. Histocompatibility and Immunogenetics Department, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
    2. Department of Immunology and Molecular Pathology, University College London, London, United Kingdom
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  • Suzanne M. Watt

    1. Stem Cells and Immunotherapies Department, Development and Research, National Blood Service, National Health Service Blood and Transplant, United Kingdom
    2. Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, United Kingdom
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Abstract

Umbilical cord blood (UCB) is an important source of hematopoietic stem cells for transplantation. Although UCB is often collected from unrelated donors, directed umbilical cord blood (DCB) from sibling donors also provides an important source of UCB for transplantation. This report summarizes the experience in collection, testing, storage, and transplantation of DCB units by the National Blood Service for England and North Wales over 10 years. Eligibility for collection was based on an existing sibling suffering from a disease that may be treated by stem cell transplantation or a family history that could result in the birth of a sibling with a disease that could be treated by stem cell transplantation. Collections were made on the provision that the sibling's clinician was willing to financially support the collection and to take responsibility for medical review of the mother and potential recipient. Given the high investment in UCB banking and the introduction of new regulations and mandatory licensing under the European Union Tissues and Cells Directive and those proposed in the U.S., this report details the procedures that we have used for DCB donations, the outcome data where donations have been used for transplantation, and it provides some timely recommendations for best practices.

Disclosure of potential conflicts of interest is found at the end of this article.

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