Bone Marrow Contributes to Epithelial Cancers in Mice and Humans as Developmental Mimicry
Article first published online: 3 MAY 2007
Copyright © 2007 AlphaMed Press
Volume 25, Issue 8, pages 1881–1887, August 2007
How to Cite
Cogle, C. R., Theise, N. D., Fu, D., Ucar, D., Lee, S., Guthrie, S. M., Lonergan, J., Rybka, W., Krause, D. S. and Scott, E. W. (2007), Bone Marrow Contributes to Epithelial Cancers in Mice and Humans as Developmental Mimicry. STEM CELLS, 25: 1881–1887. doi: 10.1634/stemcells.2007-0163
- Issue published online: 2 JAN 2009
- Article first published online: 3 MAY 2007
- Manuscript Accepted: 20 APR 2007
- Manuscript Received: 8 MAR 2007
- Bone marrow cells;
- Hematopoietic stem cell;
- Bone marrow transplantation
Bone marrow cells have the capacity to contribute to distant organs. We show that marrow also contributes to epithelial neoplasias of the small bowel, colon, and lung, but not the skin. In particular, epithelial neoplasias found in patients after hematopoietic cell transplantations demonstrate that human marrow incorporates into neoplasias by adopting the phenotype of the surrounding neoplastic environment. To more rigorously evaluate marrow contribution to epithelial cancer, we employed mouse models of intestinal and lung neoplasias, which revealed specifically that the hematopoietic stem cell and its progeny incorporate within cancer. Furthermore, this marrow involvement in epithelial cancer does not appear to occur by induction of stable fusion. Whereas previous claims have been made that marrow can serve as a direct source of epithelial neoplasia, our results indicate a more cautionary note, that marrow contributes to cancer as a means of developmental mimicry.
Disclosure of Potential Conflicts of Interest is found at the end of this article.