Concise Review: Dendritic Cell Development in the Context of the Spleen Microenvironment
Article first published online: 24 MAY 2007
Copyright © 2007 AlphaMed Press
Volume 25, Issue 9, pages 2139–2145, September 2007
How to Cite
Tan, J. K. H. and O'Neill, H. C. (2007), Concise Review: Dendritic Cell Development in the Context of the Spleen Microenvironment. STEM CELLS, 25: 2139–2145. doi: 10.1634/stemcells.2007-0244
- Issue published online: 2 JAN 2009
- Article first published online: 24 MAY 2007
- Manuscript Accepted: 17 MAY 2007
- Manuscript Received: 2 APR 2007
- Dendritic cell development;
The dendritic cell (DC) population in spleen comprises a mixture of cells including endogenous DC progenitors, DC precursors migrating in from blood and bone marrow, and DC in different states of differentiation and activation. A role for different microenvironments in supporting the dynamic development of murine DC of different types or lineages is considered here. Recent evidence for production of DC dependent on splenic stromal cells is reviewed in the light of evidence that cell production is dependent on cells comprising an endothelial niche in spleen. The possibility that self-renewing progenitors in spleen give rise to DC with tolerogenic or regulatory rather than immunostimulatory function is considered.
Disclosure of potential conflicts of interest is found at the end of this article.