CD45-Positive Blood Cells Give Rise to Uterine Epithelial Cells in Mice
Article first published online: 26 JUL 2007
Copyright © 2007 AlphaMed Press
Volume 25, Issue 11, pages 2820–2826, November 2007
How to Cite
Bratincsák, A., Brownstein, M. J., Cassiani-Ingoni, R., Pastorino, S., Szalayova, I., Tóth, Z. E., Key, S., Németh, K., Pickel, J. and Mezey, É. (2007), CD45-Positive Blood Cells Give Rise to Uterine Epithelial Cells in Mice. STEM CELLS, 25: 2820–2826. doi: 10.1634/stemcells.2007-0301
- Issue published online: 2 JAN 2009
- Article first published online: 26 JUL 2007
- Manuscript Accepted: 20 JUL 2007
- Manuscript Received: 24 APR 2007
- Adult stem cell;
- Hematopoietic stem cell;
The uterine endometrium is composed of epithelial and stromal cells, which undergo extensive degeneration and regeneration in every estrous cycle, and dramatic changes occur during pregnancy. The high turnover of cells requires a correspondingly high level of cell division by progenitor cells in the uterus, but the character and source of these cells remain obscure. In the present study, using a novel transgenic mouse, we showed that CD45-positive hematopoietic progenitor cells colonize the uterine epithelium and that in pregnancy more than 80% of the epithelium can derive from these cells. Since we also found green fluorescent protein (GFP)-positive uterine endothelial cells in long-term GFP bone marrow-transplanted mice, we conclude that circulating CD45+ cells play an important role in regenerating the uterine epithelium.
Disclosure of potential conflicts of interest is found at the end of this article.