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The 5th International Society for Stem Cell Research (ISSCR) Annual Meeting, June 2007

  1. Vinagolu K. Rajasekhar M.Sc., M.Phil., Ph.D.1,*,
  2. Piero Dalerba2,
  3. Emmanuelle Passegué3,
  4. Eric Lagasse4,
  5. Joseph Najbauer5

Article first published online: 25 OCT 2007

DOI: 10.1634/stemcells.2007-0647

Issue

STEM CELLS

STEM CELLS

Volume 26, Issue 1, pages 292–298, January 2008

Additional Information

How to Cite

Rajasekhar, V. K., Dalerba, P., Passegué, E., Lagasse, E. and Najbauer, J. (2008), The 5th International Society for Stem Cell Research (ISSCR) Annual Meeting, June 2007. STEM CELLS, 26: 292–298. doi: 10.1634/stemcells.2007-0647

Author Information

  1. 1

    Memorial Sloan-Kettering Cancer Center, New York, New York, USA

  2. 2

    Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, California, USA

  3. 3

    Institute for Regeneration Medicine, University of California, San Francisco, California, USA

  4. 4

    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

  5. 5

    City of Hope National Medical Center and Beckman Research Institute, Duarte, California, USA

*Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Rockefeller Research Laboratories, New York, New York 10021, USA. Telephone: 646-247-0060; Fax: 212-717-3627

Publication History

  1. Issue published online: 2 JAN 2009
  2. Article first published online: 25 OCT 2007
  3. Manuscript Accepted: 15 OCT 2007
  4. Manuscript Received: 14 AUG 2007

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Keywords:

  • Aberrant differentiation;
  • Adult stem cells;
  • Cancer stem cells;
  • Epigenetic alterations;
  • Glioblastoma Hematopoietic stem cells;
  • Metastasis;
  • Polycomb group proteins;
  • Self-renewal;
  • Stem cell maintenance Stem cell niche;
  • Tumor microenvironment;
  • Tumor stroma

Abstract

This report presents highlights of discussions that focused on the biology of cancer stem cells as conducted at the fifth Annual Meeting of the International Society for Stem Cell Research, held in Cairns, Australia, June 17–20, 2007. The function of adult stem cells is believed to depend on their niches, that is, the microenvironment in which these stem cells reside. A similar concept applies to understanding the development of cancer, as it is becoming increasingly clear that only a small subset of cancer cell populations is capable of initiating/sustaining tumor formation. These tumorigenic cells, commonly referred to as cancer stem cells, also appear to reside in particular niches, and they bear the known, albeit dysfunctional, stem cell characteristics of self-renewal and differentiation. Dysregulation of stem cell niches is thought to contribute to tumorigenesis by affecting the complex network of signaling interactions that occur between stem cells and their neighboring cells, thus imbalancing the physiological controls on self-renewal and differentiation processes. This hypothesis was widely explored at the conference to shed new light on the mechanisms of tumor origin and progression and to unveil novel antitumor therapeutic approaches.

Disclosure of potential conflicts of interest is found at the end of this article.

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