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Periodontal Ligament Stem Cell-Mediated Treatment for Periodontitis in Miniature Swine

  1. Yi Liu1,
  2. Ying Zheng1,
  3. Gang Ding1,
  4. Dianji Fang1,
  5. Chunmei Zhang1,
  6. Peter Mark Bartold2,
  7. Stan Gronthos3,
  8. Songtao Shi D.D.S., Ph.D.4,*,
  9. Songlin Wang D.D.S., Ph.D.1,*

Article first published online: 31 JAN 2008

DOI: 10.1634/stemcells.2007-0734

Issue

STEM CELLS

STEM CELLS

Volume 26, Issue 4, pages 1065–1073, April 2008

Additional Information

How to Cite

Liu, Y., Zheng, Y., Ding, G., Fang, D., Zhang, C., Bartold, P. M., Gronthos, S., Shi, S. and Wang, S. (2008), Periodontal Ligament Stem Cell-Mediated Treatment for Periodontitis in Miniature Swine. STEM CELLS, 26: 1065–1073. doi: 10.1634/stemcells.2007-0734

Author Information

  1. 1

    Salivary Gland Disease Center and the Molecular Laboratory for Gene Therapy, Capital Medical University School of Stomatology, Beijing, China

  2. 2

    Colgate Australian Clinical Dental Research Centre, Dental School, University of Adelaide, South Australia, Australia

  3. 3

    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science/Hanson Institute, Adelaide, South Australia, Australia

  4. 4

    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, California, USA

*Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, 2250 Alcazar Street, CSA 103, Los Angeles, California 90033, USA. Telephone: 323-442-3038; Fax: 323-442-2981

Publication History

  1. Issue published online: 2 JAN 2009
  2. Article first published online: 31 JAN 2008
  3. Manuscript Accepted: 20 JAN 2008
  4. Manuscript Received: 5 SEP 2007

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Keywords:

  • Periodontal ligament stem cells;
  • Periodontal disease;
  • Tissue engineering;
  • Regeneration

Abstract

Periodontitis is a periodontal tissue infectious disease and the most common cause for tooth loss in adults. It has been linked to many systemic disorders, such as coronary artery disease, stroke, and diabetes. At present, there is no ideal therapeutic approach to cure periodontitis and achieve optimal periodontal tissue regeneration. In this study, we explored the potential of using autologous periodontal ligament stem cells (PDLSCs) to treat periodontal defects in a porcine model of periodontitis. The periodontal lesion was generated in the first molars area of miniature pigs by the surgical removal of bone and subsequent silk ligament suture around the cervical portion of the tooth. Autologous PDLSCs were obtained from extracted teeth of the miniature pigs and then expanded ex vivo to enrich PDLSC numbers. When transplanted into the surgically created periodontal defect areas, PDLSCs were capable of regenerating periodontal tissues, leading to a favorable treatment for periodontitis. This study demonstrates the feasibility of using stem cell-mediated tissue engineering to treat periodontal diseases.

Disclosure of potential conflicts of interest is found at the end of this article.

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