Thrombopoietin Inhibits Murine Mast Cell Differentiation
Article first published online: 14 FEB 2008
Copyright © 2008 AlphaMed Press
Volume 26, Issue 4, pages 912–919, April 2008
How to Cite
Martelli, F., Ghinassi, B., Lorenzini, R., Vannucchi, A. M., Rana, R. A., Nishikawa, M., Partamian, S., Migliaccio, G. and Migliaccio, A. R. (2008), Thrombopoietin Inhibits Murine Mast Cell Differentiation. STEM CELLS, 26: 912–919. doi: 10.1634/stemcells.2007-0777
- Issue published online: 2 JAN 2009
- Article first published online: 14 FEB 2008
- Manuscript Accepted: 31 JAN 2008
- Manuscript Received: 18 SEP 2007
- Mast cells;
We have recently shown that Mpl, the thrombopoietin receptor, is expressed on murine mast cells and on their precursors and that targeted deletion of the Mpl gene increases mast cell differentiation in mice. Here we report that treatment of mice with thrombopoietin or addition of this growth factor to bone marrow-derived mast cell cultures severely hampers the generation of mature cells from their precursors by inducing apoptosis. Analysis of the expression profiling of mast cells obtained in the presence of thrombopoietin suggests that thrombopoietin induces apoptosis of mast cells by reducing expression of the transcription factor Mitf and its target antiapoptotic gene Bcl2.
Disclosure of potential conflicts of interest is found at the end of this article.